Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ 4α-Phorbol-12,13-didecanoate
Inactive on mouse skin as an inflammatory and tumor-promoting agent.
MilliporeSigma™ Calbiochem™ BEC, Hydrochloride
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).
MilliporeSigma™ Calbiochem™ Alendronate, Sodium Salt
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.
MilliporeSigma™ Calbiochem™ Rottlerin
Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ(IC50= 3-6μM) and PKCθ. Has about 10-fold lower potency against other isozymes.
MilliporeSigma™ Calbiochem™ 1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride
Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.
MilliporeSigma™ Calbiochem™ IRAP Inhibitor, HFI-419
A substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 μM against 25 μM Leu-AMC).
MilliporeSigma™ Calbiochem™ Cucurbitacin I, Cucumis sativus L.
A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo.
MilliporeSigma™ Calbiochem™ W-5, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 μM).
MilliporeSigma™ Calbiochem™ LRRK2-IN-1
LRRK2-IN-1 primarily used in Inhibition.
MilliporeSigma™ Calbiochem™ Heat Shock Factor 1 Inhibitor, KRIBB11
The Heat Shock Factor 1 Inhibitor, KRIBB11 controls the biological activity of Heat Shock Factor 1.
MilliporeSigma™ Calbiochem™ Calcineurin Substrate
An excellent peptide substrate for calcineurin.
MilliporeSigma™ Calbiochem™ KMO Inhibitor I, Ro 61-8048
The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ IKK Inhibitor III, BMS-345541
IKK Inhibitor III, BMS-345541, CAS 445430-58-0, is a cell-permeable, potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC50 = ≈300 nM).
MilliporeSigma™ Calbiochem™ Anaphase-Promoting Complex Inhibitor Negative Control, AAME
The Anaphase-Promoting Complex Inhibitor Negative Control, AAME, also referenced under CAS 1784-05-0, controls the biological activity of Anaphase-Promoting Complex.
MilliporeSigma™ Calbiochem™ NS309
A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO.