Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ AMPK Signaling Activator XIII, ZLN005
Calbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.
MilliporeSigma™ Calbiochem™ PI-103
A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor III
A cell-permeable benzothiazolylchromenone compound that disrupts Skp2-Skp1 interaction via direct Skp2 affinity binding and selectively prevents Skp2-, but not Fbw7- or β-TrCP-, Skp1-Cullin-1-F-box (SFC) complex-mediated substrates ubiquitination, effectively preventing Skp2 substrates activation (Akt) and degradation (p21 & p27) with concomitant down-regulation of cellular Skp2 protein level (10 to 20μM in HEK293T & PC3 cultures)
MilliporeSigma™ Calbiochem™ Camptothecin, 10-Hydroxy-, Camptotheca acuminata
A cell-permeable powerful DNA topoisomerase I inhibitor.
MilliporeSigma™ Calbiochem™ StemSelect™ PD 0332991
A cell-permeable, brain permeant, potent, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC50 = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk6/D2, respectively).
MilliporeSigma™ Calbiochem™ Raf Kinase Inhibitor IV
The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Telomerase Inhibitor IX
The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Piperlongumine
A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53.
MilliporeSigma™ Calbiochem™ Carboplatin
An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.
MilliporeSigma™ Calbiochem™ Okadaic Acid, Sodium Salt
Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
MilliporeSigma™ Calbiochem™ Bupropion Hydrochloride
Bupropion is a non-selective inhibitor of dopamine and noradrenalin transporters. Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs).
MilliporeSigma™ Calbiochem™ InSolution™ Simvastatin, Sodium Salt
Carboxylate form of Simvastatin that is active in whole cells and in cell-free assays.
MilliporeSigma™ Calbiochem™ RAD51 Inhibitor, B02
The RAD51 Inhibitor, B02 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Galanthamine, Hydrobromide
A competitive and reversible inhibitor of acetylcholinesterase.
MilliporeSigma™ Calbiochem™ SREBP Processing Inhibitor, Betulin
The SREBP Processing Inhibitor, Betulin, also referenced under CAS 473-98-3, controls the biological activity of SCAP (SREBP cleavage activating protein). This small molecule/inhibitor is primarily used for Cell Signaling applications.