Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ D,L-Sulforaphane
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
MilliporeSigma™ Calbiochem™ Cytochalasin D, Zygosporium mansonii
Cytochalasin D, Zygosporium mansonii, CAS 22144-77-0, is a fungal toxin that is about 10-fold more potent than cytochalasin B in inhibiting actin filament function. Blocks cytoplasmic division.
MilliporeSigma™ Calbiochem™ 1-β-D-Arabinofuranosylcytosine
Anticancer, antiviral agent that is especially effective against leukemias.
MilliporeSigma™ Calbiochem™ Cathepsin D Substrate I
Useful as a substrate for the determination of cathepsin D activity.
MilliporeSigma™ Calbiochem™ Cathepsin D/E Substrate, Fluorogenic
An internally quenched fluorogenic 11-mer peptide that acts as a sensitive and selective substrate for cathepsins D and E, but not cathepsins B, H, or L .
MilliporeSigma™ Calbiochem™ Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (≈10 to 40 μM).
MilliporeSigma™ Calbiochem™ 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 μM).
MilliporeSigma™ Calbiochem™ N-Methyl-D-aspartic Acid, Hydrate
Excitatory amino acid neurotransmitter.
MilliporeSigma™ Calbiochem™ D-erythro-Sphingosine, N,N-Dimethyl-
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 μM) and stimulates Src kinase activity.
MilliporeSigma™ Calbiochem™ D-Amino Acid Oxidase Inhibitor III, AS057278
A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED50
MilliporeSigma™ Calbiochem™ D-Amino Acid Oxidase Inhibitor II, CBIO
The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.
MilliporeSigma™ Calbiochem™ D-Val-Phe-Lys Chloromethyl Ketone, Dihydrochloride
Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50 = 100 pM for human plasmin) over urokinase.
MilliporeSigma™ Calbiochem™ Cyclo(Arg-Gly-Asp-D-Phe-Val)
Potent inhibitor of cell adhesion.
MilliporeSigma™ Calbiochem™ Beclin-1 Activator II, retro-inverso TAT-Beclin-1
A cell-permeable, all-D-amino acid autophagy-inducing peptide.
MilliporeSigma™ Calbiochem™ Luciferase Substrate, CycLuc1
A synthetic cyclic alkylaminoluciferin with properties superior to D-luciferin. Binds to luciferase with higher affinity.