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Control products and reagents designed for clinical testing procedures. Ideal for use in performing, calibrating, monitoring, and ensuring the accuracy of diagnostic tests such as immunoassays.
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DLin-M-K-DMA (DLin-M-C2-DMA) is an ionizable cationic lipid supplied as a high-purity liquid for research use in lipid nanoparticle and other nucleic acid delivery formulations. It is commonly used to formulate LNPs for siRNA and mRNA delivery and includes solubility and storage guidance for in vitro and in vivo applications.
High purity (98.0%) suitable for formulation and research.
Ionizable cationic lipid for nucleic acid delivery applications.
Supplied as a liquid, colorless to light yellow.
Soluble in DMSO at 100 mg/mL; compatible with common in vivo vehicles.
Storage recommendations provided for long-term and solvent conditions.
Suitable for incorporation into lipid nanoparticle formulation workflows.
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Glucose-PEG2000-Cy3 is a Cy3-labeled glucose-PEG conjugate designed for fluorescent labeling and delivery studies. The Cy3 fluorophore enables visible-range fluorescence detection, while the glucose-PEG2000 moiety promotes cellular uptake and can reduce endosomal degradation.
Cy3 fluorophore with emission maximum around 562-570 nm.
Peg2000 average molecular weight ~2000.
Purity typically 95.0% (by HPLC).
Suitable for immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry.
Appearance: pale purple to purple oil.
Store protected from light; in solvent store at -80°C (6 months) or -20°C (1 month).
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D-Lin-MC3-DMA is an ionizable cationic lipid that serves as a potent siRNA delivery vehicle. It is intended for research use only and not for sale to patients.
Potent siRNA delivery vehicle.
Exhibits an optimized pKa value that leads to dramatically enhanced potency in vivo when formulated in lipid nanoparticles (LNPs) for siRNA delivery.
Can be formulated into lipid nanoparticles with specific molar ratios for siRNA targeting transthyretin (TTR) mRNA.
LNP-siRNA systems containing D-Lin-MC3-DMA optimize gene silencing potency in hepatocytes following IV administration in mice.
Available in various quantities and solution formats.
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DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and an αv-integrins targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and is then proteolytically cleaved in the tumor to produce CRGDK/R, which interacts with neuropilin-1. This compound has tumor-targeting and tumor-penetrating properties and can be used for agent delivery.
Irgd peptide binds to αv-integrins.
Proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1.
Possesses tumor-targeting and tumor-penetrating properties.
Can be used for agent delivery.
Used to construct nanomicelles for targeted delivery of salinomycin to intervene in liver cancer cells and cancer stem cells.
Used to construct a tumor-penetrating peptide liposome that exhibits antitumor effects, including a significant reduction in tumor volume and an increase in body weight and spleen index.
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A triacylglycerol; has been found in Kpangnana, Chinese tallow, and cocoa butters; increases the phagocytic function of reticulo-endothelial cells in mice at 5 and 10 mg per animal
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An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More