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Formula Weight: 848.145, Purity >99%, Storage Temperature: -20°C. This reagent is a modified lipid containing an omega-terminal azide. The terminal azide group can be used in a highly specific linking reaction with alkyne-containing reagents, known as ‘click chemistry’, in the presence of a copper (Cu)-containing catalyst.
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DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and an αv-integrins targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and is then proteolytically cleaved in the tumor to produce CRGDK/R, which interacts with neuropilin-1. This compound has tumor-targeting and tumor-penetrating properties and can be used for agent delivery.
Irgd peptide binds to αv-integrins.
Proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1.
Possesses tumor-targeting and tumor-penetrating properties.
Can be used for agent delivery.
Used to construct nanomicelles for targeted delivery of salinomycin to intervene in liver cancer cells and cancer stem cells.
Used to construct a tumor-penetrating peptide liposome that exhibits antitumor effects, including a significant reduction in tumor volume and an increase in body weight and spleen index.
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A triacylglycerol; has been found in Kpangnana, Chinese tallow, and cocoa butters; increases the phagocytic function of reticulo-endothelial cells in mice at 5 and 10 mg per animal
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DSPE-PEG (2000)-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. This compound is capable of forming micelles for targeted drug delivery.
Can form micelles for targeted drug delivery
Useful for polyvalent targeted delivery of vinorelbine to cancer cells
Can be used as optical coherence tomography contrast agents for tumor angiography in live animals
Targets liposome
Pathway: Metabolic enzyme/protease
Powder stable at -20°C for 3 years
In solvent stable at -80°C for 6 months, and at -20°C for 1 month
Solubility in H2O: 25 mg/mL (requires ultrasonic treatment)
Solubility in DMSO: 25 mg/mL (requires ultrasonic, warming, and heating to 60°C)
Achieves a clear solution at ≥ 2.5 mg/mL in specific in vivo solvent combinations
For research use only
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An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More