Isotopically Labeled Compounds
Medchemexpress LLC Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-di(methyl-d3)- | 1184986-45-5 | 98.7% | 1 MG
Gemfibrozil-d6 is the deuterium labeled form of Gemfibrozil, a known activator of PPAR-α and a lipid-lowering agent. It also functions as a nonselective inhibitor of several P450 isoforms. This compound is intended for research use only and serves as a valuable tool in scientific investigations, particularly as a tracer or an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Deuterium labeled form of gemfibrozil
- Activator of PPAR-α
- Used as a lipid-lowering agent
- Nonselective inhibitor of several P450 isoforms
- Suitable as a tracer in research
- Ideal as an internal standard for quantitative analysis
- Incorporates stable heavy isotopes for pharmacokinetic studies
Medchemexpress LLC Ketotifen-d3 (fumarate) | 1795138-23-6 | 99.23% | 25 MG
Ketotifen-d3 (fumarate) is the deuterium labeled form of Ketotifen fumarate. This compound acts as a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is primarily used to prevent asthma attacks and is intended for research purposes only.
- Deuterium labeled compound
- Functions as a noncompetitive H1-antihistamine
- Acts as a mast cell stabilizer
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis (e.g., NMR, GC-MS, LC-MS)
Medchemexpress LLC Rimantadine-d4 hydrochloride | 350818-67-6 | 99.0% | 1 MG
Rimantadine-d4 hydrochloride is a deuterium-labeled version of Rimantadine hydrochloride, an orally active antiviral compound. It functions as an inhibitor for the M2 protein, which is crucial for blocking the hydrogen ion channel activity of the virus, thereby preventing its entry and replication. This mechanism of action provides broad-spectrum antiviral activity. This compound is particularly useful in research for quantitation during drug development and as an internal standard for quantitative analysis.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium-labeled compound
- Exhibits broad-spectrum antiviral activity
- Blocks hydrogen ion channel activity
Medchemexpress LLC Sulfadimethoxine-d6 | 73068-02-7 | 99.0% | 5 MG
Sulfadimethoxine-d6 is the deuterium-labeled form of Sulfadimethoxine, a sulfonamide antibiotic used to treat various infections. This compound is intended for research use only.
- Used as a tracer or internal standard for quantitative analysis
- Suitable for methods such as NMR, GC-MS, or LC-MS
- Isotope-labeled compound
- Internal standard for clinical mass spectrometry, food, pesticides, and veterinary medicine
- Stable isotope-labeled inhibitor for in vivo cell experiments
- Used in therapeutic drug monitoring (TDM)
Medchemexpress LLC Tiopronin-d3 | 1189700-74-0 | 99.4% | 1 MG
Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin acts as a diffusible antioxidant, an antidote to heavy metal poisoning, and a radioprotective agent. It can regulate the rate of cystine precipitation and excretion, showing potential for treating cystinuria, rheumatoid arthritis, and hepatic disorders. For research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Betaxolol-d5 | 1189957-99-0 | >95.0% | 1 MG
Betaxolol-d5 is the deuterium-labeled version of Betaxolol. Betaxolol is a selective beta1 adrenergic receptor blocker that can be utilized in research pertaining to hypertension and glaucoma. This compound can serve as a tracer and as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. Stable heavy isotopes, including deuterium, have been incorporated into drug molecules primarily to act as tracers for quantitation during the drug development process. Deuteration is notable for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer for quantitation during drug development.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration may influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Sotalol-d6 hydrochloride | 1246820-85-8 | 99.0% | 5 MG
Sotalol-d6 hydrochloride is a deuterium labeled Sotalol hydrochloride. It is an orally active, non-selective competitive β-adrenergic receptor blocker and a potent antiarrhythmic agent. It blocks β-receptors and potassium KCNH2 channels.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 4,4'-((Pentane-1,5-diyl-1,1,5,5-d4)bis(oxy))dibenzimidamide dihydrochloride | 1276197-32-0 | 98.0% | 5 MG
This product is Pentamidine-d4 dihydrochloride, with a purity of 98.0%. It appears as a white to off-white solid. It has a molecular formula of C19H22D4Cl2N4O2 and a molecular weight of 417.37. It is intended for research use only.
- Appearance: White to off-white solid
- Purity: 98.0%
- Isotopic enrichment: 99.2%
- Molecular formula: C19H22D4Cl2N4O2
- Molecular weight: 417.37
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
Medchemexpress LLC Dopamine-d5 (hydrochloride) | 2193106-55-5 | 99.6% | 5 MG
Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). It is a white to off-white solid that acts as a catecholamine neurotransmitter. This compound is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain, playing several important roles through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. It is suitable for research use only.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Xylometazoline-d4 hydrochloride | 1218-35-5 | 5 MG
Xylometazoline-d4 hydrochloride is a deuterated labeled version of Xylometazoline hydrochloride. Xylometazoline hydrochloride is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM) that can constrict nasal blood vessels and increase nasal airflow. It is used in research related to nose stuffiness and runny nose.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Benzyl benzoate-d5 | 347840-01-1 | 99.8% | 50 MG
Benzyl benzoate-d5 is a deuterium-labeled form of Benzyl benzoate. Benzyl benzoate (benzoic acid benzyl ester) is used as a fragrance ingredient in cosmetic products and in research related to scabies and demodex-associated inflammatory skin conditions. It is for research use only.
- Deuterium-labeled compound
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, or LC-MS techniques
- Potential to influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Doxapram-d8 | 309-29-5 | 99.5% | 1 MG
Doxapram-d8 is deuterated labeled Doxapram, which is a respiratory stimulant. It increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Benzethonium-d7 chloride | 121-54-0 | 98.6% | 1 MG
Benzethonium-d7 chloride is a deuterium-labeled form of Benzethonium chloride. It inhibits human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. This compound is suitable for various analytical applications.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium (2H, D) stable isotope-labeled inhibitor
- Suitable for in vivo cell experiments
- Used in therapeutic drug monitoring
Medchemexpress LLC Creatinine-d5 | 60-27-5 | 99.9% | 1 MG
Creatinine-d5 is the deuterium-labeled version of Creatinine. Creatinine is a breakdown product of creatine phosphate found in muscle, and the body typically produces it at a consistent rate. This compound is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS
- Stable heavy isotopes can be incorporated into drug molecules for use as tracers in drug development for quantitation
- Deuteration is being explored for its potential to impact the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Proguanil-d6 (hydrochloride) | 1 MG
Proguanil-d6 (hydrochloride) is a deuterium-labeled form of Proguanil hydrochloride, an antimalarial proagent metabolized to the active metabolite Cycloguanil. It functions as a dihydrofolate reductase (DHFR) inhibitor. This product is a solid, intended for research use only, and suitable for use as a laboratory chemical in the manufacture of substances.
- Deuterium-labeled compound
- Functions as an antimalarial proagent
- Metabolized to the active metabolite cycloguanil
- Dihydrofolate reductase (DHFR) inhibitor
- Useful as a laboratory chemical
- Appears as a solid
- Intended for research use only