Isotopically Labeled Compounds
Medchemexpress LLC Tristearin-d5 | 55256-03-6 | 98.9% | 50 MG
Tristearin-d5 is a deuterium labeled triglyceride derived from three units of stearic acid. It is intended for research use only, not for patient use. Stable heavy isotopes, such as deuterium in Tristearin-d5, are often incorporated into drug molecules for use as tracers during the drug development process, with the potential to influence pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Yohimbine-d3 | 133146-00-6 | 99.36% | 1 MG
Yohimbine-d3 is a deuterium-labeled version of Yohimbine (HY-12715). This compound serves as a tracer and can be used as an internal standard for quantitative analysis through techniques like NMR, GC-MS, or LC-MS. Deuterium substitution in drug molecules is being explored for its potential to influence pharmacokinetic and metabolic profiles.
- Deuterium labeled yohimbine.
- Can be used as a tracer.
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration may impact pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Piribedil-d8 | 1398044-45-5 | 99.8% | 1 MG
Piribedil-d8 is a deuterium-labeled analog of Piribedil, an antiparkinsonian agent known for its activity as a dopamine D2 and D3 agonist and α2-adrenoceptors antagonist. This compound serves as a valuable tracer and internal standard for quantitative analysis in various analytical techniques, including NMR, GC-MS, and LC-MS.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Acts as a dopamine D2 and D3 agonist
- Serves as an α2-adrenoceptors antagonist
- Inhibits MLL1 methyltransferase activity
- Potential for research in Parkinson's disease, circulatory disorders, and cancers
Medchemexpress LLC Fingolimod-d4 | 1346747-38-3 | 99.1% | 311.50 | 1 ML
Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, an immunosuppressant.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC D-Glucose-13C2 | 201741-04-0 | 98.0% | 5 MG
D-Glucose-13C2 is a 13C labeled form of D-Glucose, a vital monosaccharide in biology. D-Glucose functions as a carbohydrate sweetener and plays a crucial role in general metabolism. It also serves as a critical signaling molecule involved in cellular metabolic status and responses to biotic and abiotic stress.
- Can be used as a tracer for various applications.
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes aids in quantitation during drug development.
Medchemexpress LLC 1-Pyrrolidine-2,2,3,3,4,4-d6-acetamide, α-ethyl-5-oxo-, (αS)- | 1133229-30-7 | 98.7% | 176.25 | 100 MG
Levetiracetam-d6 (ring-d6) is an internal standard designed for determining Levetiracetam content in whole blood. This product is for research use only and not sold to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC DPPC-d9 (Synonyms: 129Y83-d9) | 63-89-8 | 95.0% | 743.09 | 100 MG
DPPC-d9 is a deuterium-labeled DPPC. DPPC is a zwitterionic phosphoglyceride used for preparing liposomal monolayers. DPPC-liposome effectively serves as a delivery vehicle for inducing immune responses against GSL antigen in mice.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Hydroxyzine-d4 (dihydrochloride) | 1219805-91-0 | 98.0% | 1 MG
Hydroxyzine-d4 (dihydrochloride) is a deuterium-labeled form of Hydroxyzine. This compound acts as a heterocyclic histamine H1-receptor antagonist and possesses anticholinergic, anxiolytic, and analgesic properties.
- Can be used as a tracer.
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Targets the H1 receptor.
- Molecular weight is 451.85.
- Chemical formula is C21H25D4Cl3N2O2.
- Purity (NMR) is 98.0%.
- Recommended storage for powder is -20°C for 3 years.
- Recommended storage in solvent is -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC (R)-Amlodipine-d4 | 1346616-97-4 | 1 MG
(R)-Amlodipine-d4 is the deuterium labeled (R)-Amlodipine. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled (R)-Amlodipine
- Incorporates stable heavy isotopes as tracers for quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- For research use only
Medchemexpress LLC Amlodipine-d4 (maleate) | 2714486-25-4 | 98.2% | 5 MG
Amlodipine-d4 (maleate) is the deuterium-labeled Amlodipine maleate, a dihydropyridine calcium channel blocker. It functions as an orally active antianginal agent by blocking voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. This compound is valuable for research into high blood pressure and cancer.
- Functions as a tracer in drug development processes.
- Serves as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Aids in the study of high blood pressure and cancer.
- Offers potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Phenacetin-d5 (acetophenetidin-d5) | 69323-74-6 | 99.5% | 5 MG
Phenacetin-d5 is the deuterium-labeled version of Phenacetin. Phenacetin (Acetophenetidin) is an analgesic/antipyretic agent that is non-opioid. It acts as a selective COX-3 inhibitor and is used as a probe for cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. Deuteration, the incorporation of stable heavy isotopes of hydrogen into drug molecules, has shown potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Phenacetin-13C | 72156-72-0 | 99.9% | 100 MG
Phenacetin-13C is the 13C labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent and a selective COX-3 inhibitor. It is used as a probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development
Medchemexpress LLC Thiamphenicol-d3 | 2211914-19-9 | 99.5% | 1 MG
Thiamphenicol-d3 is a deuterium labeled form of Thiamphenicol, a broad-spectrum antimicrobial antibiotic. As a methyl-sulfonyl derivative of Chloramphenicol, it functions by binding to the 50S ribosomal subunit, which inhibits protein synthesis. This mechanism provides a bacteriostatic effect against a range of bacteria, including Gram-negative, Gram-positive aerobic, and anaerobic types.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Carbidopa-d3 monohydrate | 1276197-58-0 | 98.5% | 1 MG
Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Additionally, Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator and has shown to inhibit pancreatic cancer cell and tumor growth.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis via NMR, GC-MS, or LC-MS.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Benzoic acid-13C | 3880-99-7 | 98% | 123.11 | 50 MG
Benzoic acid-13C is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.