Isotopically Labeled Compounds
Medchemexpress LLC DPPC-d62 | 25582-63-2 | 99.0% | 796.42 | 50 MG
DPPC-d62 is deuterium labeled DPPC. DPPC is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome can effectively serve as a delivery vehicle for inducing immune responses against GSL antigen in mice.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules, primarily as tracers for quantitation during drug development.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Sulfadoxine-d4 | 1330266-05-1 | 98.0% | 1 MG
Sulfadoxine-d4 is the deuterium labeled Sulfadoxine, a long-acting sulfonamide. It is commonly used in combination with other agents for respiratory, urinary tract, and malarial infections, and has shown to inhibit HIV replication in peripheral blood mononuclear cells.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D4-abiraterone | 154229-21-7 | 99.85% | 347.50 | 25 MG
D4-abiraterone is a significant metabolite of abiraterone. It functions as an inhibitor of CYP17A1, 3β-hydroxysteroid dehydrogenase (3βHSD), and steroid-5a-reductase (SRD5A), and also acts as an antagonist of the androgen receptor.
- Higher potency than abiraterone in blocking conversion of dehydroepiandrosterone (DHEA) in xenografts.
- Demonstrates greater affinity for mutant and wild-type androgen receptor compared to abiraterone.
- Effectively suppresses gene expression in cell lines.
- Delays tumor progression more significantly than abiraterone acetate.
- Purity: 99.85%.
- Molecular Weight: 347.50.
- Appearance: Solid, white to off-white.
- Solubility in DMSO: 10 mg/mL (28.78 mM).
Medchemexpress LLC Ranolazine-d3 | 1054624-77-9 | 99.5% | 50 MG
Ranolazine-d3 is the deuterium labeled Ranolazine, which is known as an anti-angina agent (CVT 303). It functions by inhibiting the late phase of inward sodium current (INa and IKr) at IC50 values of 6 μM and 12 μM, respectively, without influencing heart rate or blood pressure. Additionally, it serves as a partial fatty acid oxidation (FAO) inhibitor and an antianginal agent.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium substitution can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Lamotrigine-d3 | 1132746-94-1 | 1 MG
Lamotrigine-d3 is the deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. It selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, among others. It is intended for research use only. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Ketotifen-d3 fumarate | 1795138-23-6 | 99.2% | 50 MG
Ketotifen-d3 (fumarate) is a deuterium-labeled version of Ketotifen fumarate. This compound is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, utilized for the prevention of asthma attacks.
- Can be used as a tracer.
- Can serve as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS.
Medchemexpress LLC Sulfamethoxazole-13C6 | 1196157-90-0 | 99.9% | 1 MG
Sulfamethoxazole-13C6 is a 13C labeled Sulfamethoxazole (Ro 4-2130-13C6), which is a sulfonamide antibiotic with widespread antibacterial activity. It inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase.
- Suitable for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.
- Can be used as a tracer.
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Alpha-D-glucose-13C | 287100-64-5 | 99.4% | 10 MG
Alpha-D-glucose-13C is the 13C labeled alpha-D-glucose, an endogenous metabolite. It is commonly used for research applications such as:
- Tracer studies
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Diuron-d6 | 1007536-67-5 | 99.5% | 1 MG
Diuron-d6 is a deuterium-labeled form of Diuron, an orally active phenylurea herbicide. It functions by inhibiting photosynthesis in plants, specifically by blocking the formation of ATP and NADH. Diuron-d6 also increases the production of Reactive Oxygen Species (ROS) and the expression of p53 in certain cell lines, and has shown herbicidal activity against various broadleaf and grass weeds. It has been noted to promote bladder cancer in some studies and is applicable in breast cancer research.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Probenecid-d14 | 1189657-87-1 | 99.5% | 1 MG
Probenecid-d14 is the deuterium labeled version of Probenecid. Probenecid is recognized as a potent and selective agonist for transient receptor potential vanilloid 2 (TRPV2) channels and has been observed to inhibit pannexin 1 channels. This compound is intended for research use only and can be utilized as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium-labeled version of Probenecid
- Potent and selective agonist for TRPV2 channels
- Inhibits pannexin 1 channels
- Can be used as a tracer for quantitative analysis
- Can be used as an internal standard for quantitative analysis
- Molecular weight: 299.45
- Chemical formula: C13H5D14NO4S
- Appearance: Solid
- Color: White to off-white
- For research use only
Medchemexpress LLC Thiamphenicol-d3 | 2211914-19-9 | 99.5% | 5 MG
Thiamphenicol-d3 is a deuterium labeled Thiamphenicol, a broad-spectrum antimicrobial antibiotic. It inhibits protein synthesis by binding to the 50S ribosomal subunit, resulting in a bacteriostatic effect against Gram-negative, Gram-positive aerobic, and anaerobic bacteria. This compound is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes of hydrogen, carbon, and other elements incorporated into the drug molecule
- Potential to affect the pharmacokinetic and metabolic profiles of drugs due to deuteration
Medchemexpress LLC Nizatidine-d3 | 1246833-99-7 | 98.8% | 5 MG
Nizatidine-d3 is the deuterium-labeled form of Nizatidine, a potent and orally active histamine H2 receptor antagonist. It is used in the research of stomach and intestinal ulcers by decreasing gastric acid secretion and preventing ulcer recurrence. Its deuterium labeling makes it valuable as a tracer and internal standard for quantitative analysis in drug development.
- Deuterium labeled Nizatidine
- Potent and orally active histamine H2 receptor antagonist
- Used for research of stomach and intestines ulcers
- Decreases secretion of gastric acid
- Prevents ulcers from returning after healing in animal models
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Ketoprofen-13C,d3 | 1189508-77-7 | 1 MG
Ketoprofen-13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Desloratadine-d5 | 1020719-34-9 | >99.7% | 1 MG
Desloratadine-d5 is a deuterium-labeled version of Desloratadine, an orally active major metabolite of the nonsedating H1-antihistamine Loratadine. It functions as a selective H1-receptor antagonist with anti-allergic and anti-inflammatory activities.
- Used as a tracer for quantitative analysis
- Acts as a selective H1-receptor antagonist
- Possesses anti-allergic and anti-inflammatory properties
- Can serve as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes for drug development and quantitation
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Ketoprofen-d3 | 159490-55-8 | 99.4% | 5 MG
Ketoprofen-d3 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. It is for research use only. This compound can be used as a tracer and as an internal standard for quantitative analysis.
- Deuterium labeled compound
- Non-steroidal anti-inflammatory agent
- Potent inhibitor of COX-1 and COX-2
- Used as a tracer for quantitation during drug development
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS