Isotopically Labeled Compounds
Medchemexpress LLC Deoxycholic acid | 83-44-3 | 392.57 | 10 G
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism that activates the G protein-coupled bile acid receptor TGR5. It induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress. DCA-induced resistant cells show altered morphology, significantly elevated telomerase activity, better cell viability, and reduced apoptosis compared to normal MGC803 cells.
- Activates the G protein-coupled bile acid receptor TGR5.
- Induces resistance in gastric cancer cell lines to acidified bile acids.
- Enhances survival and proliferation activity of gastric cancer cells under bile acid stress.
- Increases telomerase activity in resistant cells.
- Improves cell viability and reduces apoptosis in resistant cells.
Medchemexpress LLC (E)-2,3',4,5'-tetramethoxystilbene | 24144-92-1 | 99.4% | 300.35 | 1 ML
TMS ((E)-2,3′,4,5′-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. It shows a lesser inhibitory effect on CYP1A1 (IC50=300 nM) and CYP1A2 (IC50=3.1 μM). This methylated derivative of resveratrol possesses anti-cancer activity.
- Selective and competitive CYP1B1 inhibitor
- Possesses anti-cancer activity
- IC50 for CYP1B1 is 6 nM
- IC50 for CYP1A1 is 300 nM
- IC50 for CYP1A2 is 3.1 μM
Medchemexpress LLC (S)-Cystathionine-d4 | 61949-06-2 | 97.1% | 226.29 | 1 MG
(S)-Cystathionine-d4 is the deuterium labeled (S)-Cystathionine. It is for research use only and not sold to patients. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Docosanoic acid-d43 (Behenic acid-d43) | 29823-26-5 | 99.3% | 383.85 | 5 MG
Docosanoic acid-d43 (Behenic acid-d43) is the deuterium labeled Docosanoic acid. Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid that inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Cayman Chemical FenretInIde-d4 1mg
An internal standard for the quantification of fenretinide by GC- or LC-MS
Cambridge Isotope Laboratories BILE ACID STANDARD 1 MIX (UNCO
BILE ACID STANDARD 1 MIX (UNCONJUGATED) UNLABELED STANDARD, 1 VIAL
Cayman Chemical AldIcarb sulfon 50mg
A metabolite and degradation product of aldicarb; reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development at 100 μg/ml
Cambridge Isotope Laboratories ALPHA-KETOISOVALERIC ACID, SODIUM SALT (13C5, 98%) 0.25 GCAS# 1173018-24-0
ALPHA-KETOISOVALERIC ACID, SODIUM SALT (13C5, 98%) 0.25 GCAS# 1173018-24-0
![Revvity Health Sciences Inc Methionine, L-[<sup>35</sup>S]-, 1mCi (37MBq), Specific Activity:>1000Ci (37.0TBq)/mmol, 10mM BME](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502809820.jpg-250.jpg)
Revvity Health Sciences Inc Methionine, L-[35S]-, 1mCi (37MBq), Specific Activity:>1000Ci (37.0TBq)/mmol, 10mM BME
Methionine, L-[35S]-, 1mCi (37MBq), Specific Activity:>1000Ci (37.0TBq)/mmol, 10mM BME
Cayman Chemical CaspofungIn-d4acetate 500ug
An internal standard for the quantification of caspofungin by GC- or LC-MS
Medchemexpress LLC L-Tryptophan-d5 | 62595-11-3 | 209.26 | 100 MG
L-Tryptophan-d5 is a deuterium labeled L-Tryptophan, which is an essential amino acid and a precursor of serotonin, melatonin, and vitamin B3. Deuteration of drug molecules has garnered attention for its potential impact on pharmacokinetic and metabolic profiles.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes can be incorporated into drug molecules for quantitation during drug development.
Medchemexpress LLC DL-Tryptophan-d8 | 1233395-85-1 | 99.6% | 212.27 | 10 MG
DL-Tryptophan-d8 is the deuterium labeled DL-Tryptophan, an endogenous metabolite.
- Can be used as a tracer.
- Can be used as an internal standard in NMR, GC-MS, or LC-MS analysis for quantitative analysis.