Isotopically Labeled Compounds
Medchemexpress LLC 2-Oxazolidinone-4,4,5-d3, 3-amino-5-(4-morpholinylmethyl-d2)- | 1017793-94-0 | 99.0% | 25 MG
AMOZ-d5 is a deuterium labeled AMOZ. AMOZ is described as a tissue-bound metabolite of Furaltadone, which is a widely used synthetic nitrofuran antibiotic. This product is intended for research use only and not for sale to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Istradefylline-13C,d3 | 2749234-46-4 | 98.3% | 388.44 | 10 MG
Istradefylline-13C,d3 is the 13C- and deuterium labeled version of Istradefylline, a highly potent, selective, and orally active adenosine A2A receptor antagonist with a Ki of 2.2 nM. It has been studied in experimental models of Parkinson's disease. This compound is intended for research use only and can be used for quantitative analysis.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Sorafenib-d3 (Donafenib; Bay 43-9006-d3) | 1130115-44-4 | 99.57% | 467.84 | 25 MG
Sorafenib-d3 (Donafenib) is a deuterated compound of Sorafenib, recognized as the first deuterium-generation tumor suppressor small molecule. Sorafenib itself is a multikinase inhibitor with IC50s of 6 nM for Raf-1, 20 nM for B-Raf, and 22 nM for VEGFR-3. This compound is intended for research use only. Potential advantages of deuterated compounds like Sorafenib-d3 include:
- Extends the in vivo half-life.
- Improves oral bioavailability.
- Enhances metabolic characteristics.
- Improves drug safety.
- Preserves therapeutic properties.
Medchemexpress LLC Fenofibric acid-d6 | 1092484-69-9 | 99.6% | 5 MG
Fenofibric acid-d6 (FNF acid-d6) is the deuterium-labeled form of Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, acts as a PPAR activator with EC50s of 22.4 μM for PPARα, 1.47 μM for PPARγ, and 1.06 μM for PPARδ. It also inhibits COX-2 enzyme activity with an IC50 of 48 nM. Deuterium substitution in drug molecules is of interest due to its potential impact on pharmacokinetic and metabolic profiles.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- For research use only.
Medchemexpress LLC Sulbactam-d5 sodium | 1322625-44-4 | 99.9% | 500 UG
Sulbactam-d5 sodium is a deuterium-labeled form of Sulbactam sodium, a competitive, irreversible beta-lactamase inhibitor. It demonstrates antimicrobial activity against multidrug-resistant Acinetobacter calcoaceticus--Acinetobacter baumannii complex. Deuteration in drug molecules can impact pharmacokinetic and metabolic profiles, making this compound valuable for research.
- Functions as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Isotope-labeled compound
- Deuterium stable isotope-labeled inhibitor for in vivo cell experiments
- Applicable in therapeutic drug monitoring
Medchemexpress LLC Alfuzosin-d3 | 1006724-55-5 | 99.9% | 1 MG
Alfuzosin-d3 is deuterium labeled Alfuzosin. This compound can be used as a tracer and as an internal standard for quantitative analysis. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes incorporated into drug molecules
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Estrone-d2 | 350820-16-5 | 99.78% | 1 MG
Estrone-d2 is a deuterium-labeled form of Estrone (E1), a natural estrogenic hormone primarily produced by various tissues. It is intended for research use only and serves as a tracer or internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Used as a tracer for quantitative analysis
- Functions as an internal standard for quantitative analysis
- Deuterium-labeled form of estrone
- For research use only
Medchemexpress LLC Acetylcholine-d9 (chloride) | 344298-95-9 | 99.0% | 5 MG
Acetylcholine-d9 (chloride) is a deuterium-labeled Acetylcholine chloride, a neurotransmitter and a potent, BBB-permeable cholinergic agonist. It modulates dopaminergic neuron activity by stimulating nicotinic acetylcholine receptors (nAChRs) and inhibits p53 mutant peptide aggregation in vitro.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Glucose-13C,d | 83379-46-8 | 1 MG
D-Glucose-13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose) is a monosaccharide and an important carbohydrate in biology, serving as a critical component of general metabolism and a carbohydrate sweetener. This compound can be used as a tracer and as an internal standard for quantitative analysis.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes for drug development processes
Medchemexpress LLC Busulfan-d8 | 116653-28-2 | 99.7% | 1 MG
Busulfan-d8 is a deuterium labeled Busulfan, functioning as a potent alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins, inhibits thioredoxin reductase, and induces apoptosis. This compound acts as an immunosuppressive and myeloablative chemotherapeutic agent.
- Deuterium labeled compound
- Functions as a potent alkylating antineoplastic agent
- Causes DNA damage by cross-linking DNAs and DNA and proteins
- Inhibits thioredoxin reductase and induces apoptosis
- Acts as an immunosuppressive and myeloablative chemotherapeutic agent
- Can be used as a tracer for quantitation during drug development
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Guanidine-d5 (hydrochloride) | 108694-93-5 | 98% | 100 MG
Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride), a strong chaotrope, is also a strong denaturant of proteins. This product is for research use only and not for sale to patients. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to influence pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC D-Glucose-d1-4 | 106032-61-5 | 98.0% | 100 MG
D-Glucose-d1-4 is the deuterium labeled D-Glucose. This monosaccharide is an important carbohydrate in biology, serving as a critical component of general metabolism and a significant signaling molecule for cellular metabolic status and stress response.
- Deuterium labeled D-Glucose
- Important carbohydrate in biology
- Critical component of general metabolism
- Significant signaling molecule
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Bromhexine-d3 hydrochloride | 611-75-6 | 99.0% | 1 MG
Bromhexine-d3 (hydrochloride) is a deuterium-labeled Bromhexine (hydrochloride) that functions as a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. It holds potential for preventing and managing SARS-CoV-2 infection and also acts as an autophagy agonist. Additionally, Bromhexine hydrochloride serves as a mucolytic cough suppressant, suggesting its utility in various respiratory conditions. This product is intended for research use only.
- Deuterium labeled Bromhexine (hydrochloride)
- Potent and specific TMPRSS2 protease inhibitor
- Can prevent and manage SARS-CoV-2 infection
- Autophagy agonist
- Mucolytic cough suppressant
- Used as a tracer or internal standard for quantitative analysis
Medchemexpress LLC Clotrimazole-d10 | 23593-75-1 | 97.5% | 354.90 | 1 MG
Clotrimazole-d10 is a deuterated labeled form of Clotrimazole (HY-10882), which is an imidazole derivative known for its antifungal properties and as a CYP (cytochrome P450) inhibitor. This compound also exhibits antibacterial activity, making it versatile for various research applications.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Glycine-2-13C | 20220-62-6 | MFCD00037550 | 99.3% | 76.06 g/mol | H2N13CH2COOH | 5mg
Glycine-2-13C is the 13C-labeled Glycine Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors