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Molecular sieves are materials with pores of uniform size and diameter that are similar in size to small molecules; used to separate molecules by size; available in various pore size ranges, with drying solvent indicators, etc.
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A cholane-scaffold small molecule that functions as a selective agonist of GPBAR1 (TGR5) and is used in research on FXR and bile-acid receptor-mediated signaling. Supplied in solution and solid formats for flexibility in assay setup, it is intended for in vitro pharmacology and signaling studies.
High purity suitable for biochemical and cell-based assays.
Available as a 10 mM solution in DMSO for immediate use in assays.
Also offered as solid material in multiple sizes for dose optimization.
Molecular formula and weight provided to support analytical planning.
Commonly used in studies of bile acid receptor signaling and metabolic disease models.
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Cayman’s 15-PGDH Inhibitor Screening Assay Kit provides a robust and EAsy-to-use platform for identifying novel inhibitors of human 15-PGDH, the enzyme that catalyzes the oxidation of prostaglandins to 15-keto metabolites with reduced biological activity. Measurement of 15-PGDH activity is carried out by monitoring the reduction of NAD+ to NADH. The reduction of NAD+ to NADH is accompanied by an increase in fluorescence at 445 nm following excitation at 340 nm. The potent and reversible 15-PGDH inhibitor ML-148 Assay Reagent is included as a positive control and inhibits 15-PGDH with an IC50 value of 11 nM.
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AVG-233 (CAS 2151937-80-1) is a small-molecule RNA-dependent RNA polymerase (RdRp) inhibitor used for research on respiratory syncytial virus (RSV). It prevents initiation of the viral polymerase complex and shows nanomolar activity against RSV isolates (reported EC50 = 0.14-0.31 μM). Supplied as an off-white to yellow solid for laboratory use.
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Recombinant mouse Semaphorin-4A extracellular domain expressed in HEK293 cells, supplied lyophilized with a C-terminal 6xHis tag. Provided at 50 μg with >95% purity and formulated for stability; certificate of analysis and datasheet are available for quality verification.
Mouse extracellular domain (residues T33-H682).
Expressed in HEK293 mammalian cells for proper folding and post-translational modifications.
C-terminal 6xHis tag for affinity purification and detection.
Lyophilized formulation with stabilizers for extended storage stability.
Purity greater than 95% as determined by reducing SDS-PAGE.
Supplied at 50 μg suitable for in vitro research applications.
Certificate of analysis and datasheet provided for quality assurance.
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Regeneration or ActivationA saturated molecular sieve can be restored to its original capacity by regeneration the principle of which involves changing the conditions surrounding the adsorbent to correspond to a very low equilibrium capacity. In general the greater the difference between the equilibrium capacities of adsorption and regeneration the more rapid and complete the regeneration.The sieve may be regenerated in one of four ways1. Thermal reactivation -The maximum regeneration temperature for Silica is 300C.2. Pressure reactivation3. Passing an appropriate fluid through the gel bed at normal temperature and pressure.4. Displacement of adsorbates by passing a high concentration of molecules in a fluid through the bed.
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HFY-4A is an HDAC inhibitor that inhibits breast cancer cell proliferation, migration, and invasion, and induces cell apoptosis. It also induces immunogenic cell death (ICD) and inhibits tumor growth in breast cancer xenograft mouse models.
Inhibits breast cancer cell proliferation, migration, and invasion
Induces cell apoptosis
Induces immunogenic cell death (ICD)
Inhibits tumor growth in breast cancer xenograft mouse models
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SMI-4a (TCS-PIM-1-4a) is a potent, selective, cell-permeable, and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. It also inhibits Pim-2 (IC50 of 100 μM) but does not significantly inhibit other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity.
Potent, selective, cell-permeable, and ATP-competitive Pim-1 inhibitor.
Inhibits Pim-2.
Has anticancer activity.
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