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Products for use in the clinical diagnosis of viral infections, including SARS-CoV-2, the virus that causes COVID-19, by simultaneously measuring multiple analytes from a single sample.
12(S)-hydroxy-16-Heptadecynoic acid is a mechanism-based inhibitor of CYP450 W-hydroxylase.{1051} It inhibits prostaglandin W-hydroxylase with a Ki value of 1.8 UM.{1051}
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The Mesoscale K15626U-2 is a high-performance thermoelectric cooler for optoelectronic and photonic applications offering precise temperature control It has a heat pumping capacity of 15 5W and a temperature differential of 70 C With a 27 x 27 mm footprint it features a hermetically sealed package and integrated heat sinks Known for low power consumption low noise and high reliability it stabilizes laser diode temperatures and maintains wavelengths in optical networks Its solid-state operation is ideal for cooling IR detectors CCDs and other sensitive components
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An alkaloid active against the F32 chloroquine-sensitive (IC50 0 52 UM) and FcB1 and FcM2 chloroquine-resistant strains of P falciparum (IC50s 0 52 0 8 and 0 49 UM respectively) and reduces parasitemia in a mouse model of P vinckei infection (ED50 18 9 mg/kg per day) decreases LPS-induced increases in TNF-a IL-1B and IL-6 levels and p65 nuclear translocation in RAW 264 7 cells at 5 UM decreases serum levels of IL-10 TNF-a and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia inhibits proliferation of various cancer cells (IC50s 2 65-370 ng/ml) induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0 1-10 UM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
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The Meso Scale Discovery K15653U-4 is a 96-well plate with a carbon electrode sensor for label-free detection of proteins via electrochemiluminescence (ECL) It offers high-sensitivity quantitative analysis and screening with low background and high signal-to-noise ratios The product includes 4 plates each allowing 96 assays Compatible with Meso Scale Discovery instruments and reagents it supports ECL-based immunoassays biomolecular interaction analysis and cell signaling studies featuring high sensitivity broad dynamic range and rapid assay times
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The V-PLEX Plus Cytokine Panel 1 (Mouse) Kit from Meso Scale Discovery is a multiplex immunoassay that allows simultaneous measurement of 10 mouse cytokines and chemokines (GM-CSF IFN- IL-1 IL-2 IL-4 IL-5 IL-6 IL-10 IL-12p70 and TNF- ) from cell culture supernatants serum plasma and other biological fluids The kit utilizes electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and requires low sample volume The 10-plex panel allows efficient profiling of cytokines and chemokines involved in innate and adaptive immune responses
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 2 Mouse IgG Kit is an electrochemiluminescence immunoassay that detects IgG antibodies to SARS-CoV-2 in mouse serum and plasma samples The assay uses a multiplex format to measure antibodies specific for the SARS-CoV-2 spike and nucleocapsid proteins The kit includes a plate coated with antigens detection antibodies calibrators controls diluent and wash buffer sufficient for 25 tests in a 96-well plate format The assay has high sensitivity and specificity for detecting the IgG response to SARS-CoV-2 infection or vaccination in mice
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The V-PLEX Metabolic Panel 1 Mouse Kit from Meso Scale Discovery is a multiplex immunoassay kit for measuring 10 metabolic biomarkers in mouse serum plasma and cell culture supernatants It includes a 96-well plate with capture antibodies detection antibodies calibrators controls diluent read buffer wash buffer and plate seals The analytes are albumin total cholesterol HDL LDL triglycerides glucose creatinine blood urea nitrogen phosphorus and calcium The electrochemiluminescent detection offers high sensitivity and a broad dynamic range enabling efficient metabolic profiling of mouse models
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The Meso Scale Discovery V-PLEX Plus Human ProInflam Panel II 4-plex is a kit for measuring 4 human proinflammatory biomarkers (IFN- IL-1 IL-6 and TNF- ) in serum plasma and cell culture supernatants using electrochemiluminescent detection technology The kit includes a 4-spot MULTI-ARRAY 96-well plate coated with capture antibodies detection antibodies Read Buffer Calibrator Blend and ancillary reagents needed to run the assay The lower limits of detection are sub-pg/mL The kit allows sensitive accurate and reproducible quantification of the 4 proinflammatory cytokines
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The Meso Scale Discovery V-PLEX Viral Panel 3 Human Kit is a multiplex immunoassay that simultaneously detects antibodies to SARS-CoV-2 Influenza A and Influenza B in human serum and plasma This assay uses electrochemiluminescence technology on patterned arrays for high sensitivity and a wide dynamic range The kit includes a 96-well plate detection antibodies wash buffers calibrators controls and other reagents needed to run the assay Results are obtained in as little as 3 5 hours This kit allows efficient quantitative antibody profiling against multiple viral targets from a single small sample volume
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The Mesoscale K15575U-4 is a high-performance thermoelectric cooler that provides precise temperature control for photonics and semiconductor applications It features a maximum heat pumping capacity of 15 5W and can achieve a temperature differential of up to 75 C With its compact 15 5mm x 15 5mm footprint the K15575U-4 TEC is designed for cooling small components and stabilizing sensitive devices This thermoelectric module utilizes bismuth telluride semiconductor material and incorporates a ceramic substrate for optimal thermal transfer The K15575U-4 requires a controlled DC power supply for operation
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