Cell Culture Media, Supplements, and Reagents
Genscript Corporation FGFR3 beta IIIc His Avi
Four distinct genes encoding closely related FGF receptors FGF R1-4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation differentiation and apoptosis Plays an essential role in the regulation of chondrocyte differentiation proliferation and apoptosis and is required for normal skeleton development Regulates both osteogenesis and postnatal bone mineralization by osteoblasts
Cayman Chemical AsIaloglycoproteIn RECPTR 1
A p300 and CBP inhibitor binds to the p300 and CBP bromodomains (Kds 167 and 151 nM respectively) selective for p300 and CBP over BRD4 as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 UM displaces acetylated histones from CBP in a cell-free assay (IC50 170 nM) reduces colony formation and increases differentiation of primary murine leukemic blasts and delays disease initiation following leukemic blast transplantation into sub-lethally irradiated mice when used at concentrations of 5 and 10 UM
Genscript Corporation FGFR3 alpha IIIc His Avi
Four distinct genes encoding closely related FGF receptors FGF R1-4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation differentiation and apoptosis Plays an essential role in the regulation of chondrocyte differentiation proliferation and apoptosis and is required for normal skeleton development Regulates both osteogenesis and postnatal bone mineralization by osteoblasts
eMolecules 193611-72-2 | 3-(4-(3-Chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol dihydrochloride | MFCD02684402 | 50mg
Ambeed | 23-Dichloro-6-fluorobenzoic acid | 250mg | 672838738 | A510888 | 32890-91-8 | MFCD00090506 | 209.000 | C7H3Cl2FO2
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Apexbio Technology LLC Daptomycin 103060-53-3 10mM (in 1mL DMSO)
Daptomycin is a calcium-dependent cyclic lipopeptide antibiotic exhibiting bactericidal activity against a range of Gram-positive bacteria including antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-intermediate (VISA) and vancomycin-resistant S aureus (VRSA) Its antimicrobial mechanism involves calcium-mediated insertion into bacterial cell membranes disrupting membrane integrity and depolarizing membrane potential resulting in rapid bacterial cell death Daptomycin is frequently employed in microbiological and pharmacological research to investigate antibiotic resistance mechanisms and evaluate bacterial susceptibility profiles generally showing antibacterial IC50 values in the low micromolar ( M) range
Medchemexpress LLC Erythromycin | 114-07-8 | 98.0% | 10 G
Erythromycin is a macrolide antibiotic produced by the actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. It binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blocking transpeptidation and/or translocation reactions, without affecting nucleic acid synthesis. Erythromycin also exhibits antitumor and neuroprotective effects in different fields of research.
- Binds to bacterial 50S ribosomal subunits
- Inhibits RNA-dependent protein synthesis
- Blocks transpeptidation and/or translocation reactions
- Exhibits broad spectrum antimicrobial activity
- Demonstrates antitumor effects
- Provides neuroprotective effects
Medchemexpress LLC Chloramphenicol | 56-75-7 | 100.0% | 250 MG
Chloramphenicol is an orally active, potent, and broad-spectrum antibiotic with antibacterial activity. It represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. It also suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, leading to decreased VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research.
- Inhibits HIF-1α pathway in NSCLC cells
- Induces autophagy in NSCLC cells
- Inhibits bacterial and mitochondrial protein synthesis
- Induces matrix metalloproteinase (MMP)-13 expression
- Activates JNK and PI-3K/Akt signaling
- Inhibits peptide bond formation by acting on the 50S subunit of bacterial 70S ribosomes
eMolecules 136790-76-6 | Lubiprostone | MFCD20268389 | 10mg
Ambeed | 1-(5-Carboxypentyl)-233-trimethyl-3H-indol-1-ium bromide | 5g | 650569270 | A577499 | 171429-43-9 | MFCD02063103 | 354.288 | C17H24BrNO2
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eMolecules 112901-68-5 | Amifostine trihydrate | MFCD00453866 | 250mg
Medchem Express | Z-LVG-CHN2 | 5mg | 552386388 | HY-108137 | 119670-30-3 | 445.520 | C22H31N5O5
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Biotium Growth Hormone (Pituitary Marker)(GH/3155), 1mg/mL
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly). Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye color
Medchemexpress LLC HY-10585A 5g , Valproic acid (sodium salt) Sodium Valproate CAS:1069-66-5 Purity:98%
Medchemexpress, HY-10585A 5g Valproic acid (sodium salt) Sodium Valproate CAS:1069-66-5 Formula:C8H15NaO2 IC 50 : 400 μM (HDAC1), 0.5-2 mM (HDAC) HDAC2 [6] Purity:98% Valproic acid sodium salt is an HDAC inhibitor, with IC 50 in the range of 0.5 and 2 mM, also inhibits HDAC1 ( IC 50 , 400 μM), and induces proteasomal degradation of HDAC2 ; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-13605 1g , Cytarabine Cytosine β-D-arabinofuranoside;Cytosine Arabinoside;Ara-C CAS:147-94-4 Purity:98%
Medchemexpress, HY-13605 1g Cytarabine Cytosine β-D-arabinofuranoside;Cytosine Arabinoside;Ara-C CAS:147-94-4 Formula:C9H13N3O5 IC50: 16 nM (DNA synthesis) Purity:98% Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC 50 of 16 nM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Tobramycin | 32986-56-4 | 99.9% | 10 G
Tobramycin (Nebramycin Factor 6) is a broad-spectrum aminoglycoside antibiotic, parenterally administered for moderate to severe bacterial infections due to sensitive organisms. It is also used in pneumonia research related to Pseudomonas aeruginosa.
- Target: Bacterial; antibiotic
- Pathway: Anti-infection
- Molecular formula: C18H37N5O9
- Molecular weight: 467.51
- Solubility in H2O: ≥ 100 mg/mL
- Solubility in DMSO: 2 mg/mL (needs ultrasonic)
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 2 years, -20°C for 1 year