Cell Culture Media, Supplements, and Reagents
Apexbio Technology LLC Tolvaptan 150683-30-0 5mg
Tolvaptan (CAS 150683-30-0) is a selective orally active antagonist of the arginine vasopressin (AVP) V2 receptor In binding assays using HeLa cells expressing human AVP receptor subtypes tolvaptan exhibits high affinity for the V2 receptor (Ki 0 43 nM) and substantially lower affinity for the V1a receptor (Ki 12 3 nM) with minimal activity at V1B and other off-target receptors or ion channels Tolvaptan inhibits AVP-induced cAMP accumulation with an IC50 of 8 nM In animal models administration of tolvaptan increases urine output and serum sodium and elevates plasma sodium while reducing mortality in hyponatremic rats This compound is widely utilized in research exploring water balance AVP signaling and hyponatremia mechanisms
eMolecules 55804-65-4 | Coumarin 343 acid | Broadpharm | MFCD00051335 | 285.299 | C16H15NO4 | 98.000 | OC(=O)c1cc2cc3CCCN4CCCc(c34)c2oc1=O | 100mg | 704981162
Coumarin 343 acid | Broadpharm | 55804-65-4 | MFCD00051335 | 285.299 | C16H15NO4 | 98.000 | OC(=O)c1cc2cc3CCCN4CCCc(c34)c2oc1=O | 100mg | 704981162
Apexbio Technology LLC Epalrestat 82159-09-9 10mg
Epalrestat (CAS 82159-09-9) is an orally available inhibitor of aldose reductase the rate-limiting enzyme of the polyol pathway involved in glucose metabolism By suppressing aldose reductase activity epalrestat limits intracellular sorbitol accumulation in neural tissues a process implicated in diabetic complications This compound is frequently employed in experimental models of diabetic neuropathy to investigate how modulation of the polyol pathway affects disease pathology and cellular signaling Epalrestat thus serves as a valuable molecular tool for elucidating the pathophysiology and pharmacology relevant to diabetes-associated neuronal damage
Apexbio Technology LLC Erythromycin Ethylsuccinate 1264-62-6 50mg
Erythromycin Ethylsuccinate (CAS 1264-62-6) is a small-molecule inhibitor targeting the 50S subunit of the bacterial ribosome It is designed to inhibit bacterial protein synthesis thereby disrupting bacterial growth Erythromycin Ethylsuccinate exerts its biological activity primarily through reversible attachment to the 50S ribosomal subunit resulting in the inhibition of protein biosynthesis In in vitro studies Erythromycin Ethylsuccinate demonstrates inhibitory activity against susceptible bacterial strains with IC50 values typically within the low micromolar range depending on organism type and experimental conditions Based on these pharmacological properties Erythromycin Ethylsuccinate holds research potential in studying ribosome-mediated translation processes antibiotic resistance mechanisms and bacterial physiology
Apexbio Technology LLC Orphenadrine Citrate 4682-36-4 50mg
Orphenadrine Citrate (CAS 4682-36-4) is a small molecule utilized in biomedical research for its pharmacological modulation of neurological pathways It acts by inhibiting the binding of [ 3H]MK-801 to the phencyclidine (PCP) site of the N-methyl-D-aspartate (NMDA) receptor in human frontal cortex tissue implicating antagonism at NMDA-type glutamate receptors Orphenadrine has historically served as an antiparkinsonian antispastic and analgesic agent Its ability to modulate NMDA receptor activity makes it a valuable tool for studies investigating glutamatergic neurotransmission and related neuropharmacological mechanisms
Medchemexpress LLC HY-B2174 100mg Medchemexpress, Ethacridine (lactate) CAS:1837-57-6 Purity:>98%
Medchemexpress, HY-B2174 100mg Ethacridine (lactate) CAS:1837-57-6 Ethacridine lactate is a poly(ADP-ribose) glycohydrolase ( PARG ) inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Tylosin phosphate 1405-53-4 50mg
Tylosin phosphate (CAS 1405-53-4) is a small-molecule inhibitor targeting bacterial ribosomal subunits It is designed to interfere with bacterial translation thereby inhibiting bacterial protein synthesis Tylosin phosphate exerts its biological activity primarily through binding to ribosomal subunits of Gram-positive bacteria In in vitro studies tylosin phosphate demonstrates inhibitory activity with reported IC50 values generally ranging between 0 5 5 g/mL depending on bacterial strain and assay conditions Based on these pharmacological properties tylosin phosphate holds research potential in studies of antibiotic resistance mechanisms antibacterial spectrum evaluation and as an antibiotic additive to explore growth promotion and therapeutic utility in poultry swine and bovine models
Medchemexpress LLC Ica-105665 | 2694728-63-5 | 99.9% | 355.34 | C19H15F2N3O2 | 50MG
ICA-105665 is a research compound that acts as a potent, orally active opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. It has demonstrated antiseizure activity in multiple animal models, has been evaluated clinically, and affects mitochondrial function and bile salt export at higher concentrations. Intended for research use only.
- Potent neuronal Kv7 channel opener, active orally.
- Demonstrated antiseizure activity in multiple in vivo models.
- Suitable for electrophysiology and preclinical pharmacology studies.
- High purity (>99.8%) solid for analytical and biological work.
- Soluble in DMSO at about 250 mg/mL with ultrasonic assistance.
- Powder form with storage at -20°C for long term or 4°C for short term.
- Datasheet, COA, and SDS available for quality and handling information.
- Not for human or clinical use; research use only.
Medchemexpress LLC Clarithromycin (Standard) | 81103-11-9 | 99.9% | 747.95 | 50 MG
Clarithromycin (Standard) is the analytical standard of Clarithromycin, intended for research and analytical applications. It possesses a broad spectrum of antimicrobial activity and is commonly used in qualitative, quantitative, and methodological research experiments.
- Inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation with an IC50 (Ki) value of 56 (43) μM.
- Significantly inhibits the hERG potassium current.
- Affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K.
Alkali Scientific Tobramycin Sulfate, 1 G
Tobramycin Sulfate, 1 Gram, is a potent antibiotic used for the treatment of serious infections caused by gram-negative bacteria, including Pseudomonas aeruginosa. Available in powder form, it is typically reconstituted and administered intravenously in clinical settings. The 1-gram dosage is suitable for severe infections, ensuring effective treatment for high-risk patients. Tobramycin works by inhibiting bacterial protein synthesis, preventing bacterial growth and replication. It is often used for infections in immunocompromised patients, in burn units, and for patients with cystic fibrosis, as well as in other life-threatening bacterial infections.
Alkali Scientific Spectinomycin Dihydrochloride Pentahydrate, 100 G
Spectinomycin Dihydrochloride Pentahydrate (100g) is an antibiotic used to inhibit bacterial protein synthesis, particularly effective against Gram-negative bacteria. It works by binding to the 30S subunit of the bacterial ribosome, preventing the formation of essential proteins and ultimately killing the bacteria. Spectinomycin is commonly used in microbiology for research purposes, including genetic studies and antibiotic resistance testing. This large 100g quantity is ideal for laboratories that perform extensive studies on bacterial cultures and require spectinomycin for long-term use. It is also used in experiments to study the mechanisms of bacterial resistance and the effects of protein synthesis inhibitors on bacterial growth.
Alkali Scientific L Ornithine HCl (L 2 5 Diaminopentanoic Acid), 500 G
L-Ornithine Hydrochloride (500g) is a large-scale amino acid reagent used extensively in cell culture media, particularly for the cultivation of mammalian cells. It is essential for polyamine synthesis, which is vital for cell proliferation and growth. This amino acid is also used in the study of metabolic pathways, gene expression, and protein synthesis in cell biology. The 500g package is ideal for large laboratories that require bulk quantities of ornithine for long-term experiments. It is commonly used in pharmaceutical and biotechnology labs for creating media that supports a wide variety of mammalian cell lines in culture.