Biochemical Reagents
Medchemexpress LLC Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo(RGDfC)) | 862772-11-0 | 98.1% | 578.64 | 5 MG
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) is a cyclic RGD peptide with high affinity to αvβ3, capable of disrupting cell integrin interactions. It inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo.
- High affinity to αvβ3
- Disrupts cell integrin interactions
- Inhibits pluripotent marker expression in embryonic stem cells
- Inhibits tumorigenic potential of mESCs in vivo
- Down-regulates transcription factors Oct 4, Sox 2, and Nanog in mESCs
- Inhibits integrin gene expression in mESC-col I constructs
- Promotes aggregate formation and detachment in mESCs
- Applicable in tumor research
Medchemexpress LLC Macupatide acetate | 99.7% | 4984.60 | 25 MG
Macupatide acetate is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It is used in the research of type 2 diabetes by improving insulin secretion responses and insulin sensitivity. Preclinical studies suggest it reduces body weight and fasting blood glucose.
- Improves insulin secretion responses
- Improves insulin sensitivity
- Produces larger insulin sensitivity improvement compared to selective GLP-1 RA dulaglutide
- Combination therapy with GLP-1 RA dulaglutide had additive effects on insulin sensitivity
- Reduces body weight in patients with type 2 diabetes
- Reduces fasting blood glucose in patients with type 2 diabetes
Enzo Life Sciences SB 225002 (5mg). CAS: 182498-32-4
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages. Alternative name: N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea. Purity: ≥98% (HPLC). Appearance: Yellow solid. Solubility: Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC Α2β1 integrin ligand peptide TFA (DGEA peptide TFA) | 98.6% | 504.37 | 5 MG
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane, mediating extracellular signals into cells. It is a potential antagonist of collagen receptors. In vitro studies demonstrate its ability to inhibit various viral infections and induce tyrosine kinase-dependent calcium mobilization in specific cell types.
- Interacts with the α2β1 integrin receptor
- Mediates extracellular signals into cells
- Potential antagonist of collagen receptors
- Inhibits SA11, RRV, and Wa infection in a dose-dependent manner
- Induces tyrosine kinase-dependent calcium mobilization in osteoblasts and fibroblasts
Medchemexpress LLC Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) | 70967-97-4 | 99.42% | 624.64 | 25 MG
Suc-AAPF-pNA is a chromogenic p-nitroanilide (pNA) substrate with a Km of 1.7 mM. When cleaved, it releases 4-nitroaniline, which is yellow and can be measured spectrophotometrically. This substrate is used for measuring free and membrane-bound cathepsin G in human neutrophils.
- Measures elastase activity
- Used to measure cercarial elastase activity by monitoring absorbance at 400 nm
- Hydrolysis allows for the measurement of proteolytic activity
- Enzyme activity can be measured spectrophotometrically at 410 nm
Medchemexpress LLC Genipin 1-β-D-gentiobioside | 29307-60-6 | 25 MG
Genipin 1-β-D-gentiobioside is one of the most abundant and bioactive iridoid glycosides found in *Gardenia jasminoides Ellis*. It is intended for research use only and is not sold to patients.
- Exhibits hepatoprotective activity.
- Exhibits anti-inflammatory activity.
- Exhibits antioxidant activity.
- Exhibits antithrombotic activity.
- Has a purity of 99.73%.
- Appears as a white to light yellow solid.
Sino Biological Influenza A H1N1 (A/Wisconsin/67/2022) Hemagglutinin / HA trimer Protein (His & AVI Tag), Biotinylated (MALS-verified)
A DNA sequence encoding the Influenza A virus ((A/Wisconsin/67/2022) (H1N1)) Hemagglutinin (translated amino acids of EPI2224788), termed as HA, was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Sino Biological Influenza A H1N1 (A/Wisconsin/67/2022) Hemagglutinin / HA Protein (ECD, His Tag), Endotoxin-Free
A DNA sequence encoding the Influenza A virus ((A/Wisconsin/67/2022) (H1N1)) hemagglutinin (translated amino acids of EPI2224788) (Met1-Ile530), termed as HA, was expressed with the bacteriophage T4 fibritin and a polyhistidine tag at the C-terminus.
Medchemexpress LLC Cyclo(-RGDfK) TFA | 500577-51-5 | 99.6% | 717.69 | 5 MG
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, demonstrating an IC50 of 0.94 nM. This compound effectively targets tumor microvasculature and cancer cells through specific binding to the αvβ3 integrin on the cell surface. This product is for research use only, and can be used in microPET imaging studies.
- Potent and selective inhibitor of αvβ3 integrin with an IC50 of 0.94 nM.
- Effectively targets tumor microvasculature and cancer cells.
- Binds specifically to the αvβ3 integrin on the cell surface.
- Suitable for research use only.
- Can be used in microPET imaging applications.
Medchemexpress LLC Enfuvirtide acetate | 914454-00-5 | 99.89% | 4551.93 | 25 MG
Enfuvirtide acetate is an anti-HIV-1 fusion inhibitor peptide intended for research use only. It inhibits HIV p24 antigen and Gag gene expression in macrophages.
- Anti-HIV-1 fusion inhibitor peptide
- Effective concentration for 50% inhibition (IC50) is 23 ± 6 nM in a cell-cell fusion assay
- Enhances the anti-HIV (Bal) effect of various antiretrovirals
- In vivo, has a T1/2 of 3.8 hours
Medchemexpress LLC Endothelin 1 (swine, human) TFA | 394693-38-0 | 99.8% | 2605.92 | 500 UG
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1. It is a potent endogenous vasoconstrictor and acts through two types of receptors, ETA and ETB. It is for research use only.
- Synthetic peptide with the sequence of human and swine Endothelin 1
- Potent endogenous vasoconstrictor
- Acts through two types of receptors, ETA and ETB
- For research use only
Medchemexpress LLC Glp-1(7-37) acetate | 1450806-98-0 | 99.59% | 3355.67 (free base) | 10 MG
GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion and is for research use only.
- Augments glucose induced insulin secretion
- Solid appearance
- White to off-white color
- Sequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Gr-Gly
- Soluble in H2O: 50 mg/mL (ultrasonic and adjust pH to 1 with HCl)
- Soluble in PBS: 2 mg/mL (clear solution; need ultrasonic)
Enzo Life Sciences Microcystin-HtyR (100µg)
Isolated from Microcystis aeruginosa. Microcystin containing a homotyrosine (Hty) in position 2 and arginine (R) in position 4. Hepatotoxic. Alternative name: [Hty2]microcystin-YR. Purity: ≥95% (HPLC). Appearance: White to off-white powder or oily film adhered to inside of the vial. Solubility: Soluble in methanol or DMSO. Long Term Storage: -20°C.
Sigma Aldrich Fine Chemicals Biosciences LECTIN /PHASEOLUS VULGARIS,5MG
Lectin from Phaseolus vulgaris (red kidney bean) 5mgLeucoagglutinin PHA-L, lyophilized powder, BioReagent, suitable for cell culture
Medchemexpress LLC Tyr-Gly-Gly-Phe-Met-OH | 58569-55-4 | 99.6% | 573.66 | 5 MG
Tyr-Gly-Gly-Phe-Met-OH, also known as Met-Enkephalin, is an endogenous neuropeptide that plays a crucial role in neuroendocrine and immune systems. It regulates human immune function and inhibits tumor growth by binding to the opioid receptor. This product is intended for research use only and not for medical applications.
- Regulates human immune function
- Inhibits tumor growth
- Binds to opioid receptor
- Endogenous neuropeptide
- Suitable for research applications