GDC-046 is a small-molecule TYK2 inhibitor for research use. It is potent, selective, and orally bioavailable, with reported Ki values of 4.8 nM for TYK2 and 0.7 nM, 0.7 nM, and 0.4 nM for JAK1, JAK2, and JAK3, respectively.
- Potent and selective TYK2 inhibitor with low nanomolar Ki values.
- Orally bioavailable small molecule suitable for in vitro and in vivo studies.
- High purity material (≥98%).
- Molecular formula C16H13Cl2N3O2 and molecular weight 350.2 g/mol.
- Intended for research use only; not for human or clinical use.
- Supplied as a 50 MG quantity.