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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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Apramycin sulfate is an orally active, acidic pH tolerant, and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic. It inhibits protein biosynthesis by targeting the bacterial ribosome and is a potential anti-drug-resistance antibiotic. This product is for research use only.
Inhibits protein biosynthesis by targeting the bacterial ribosome
Functions as a potential anti-drug-resistance antibiotic
Effective against a range of clinical isolates including K. pneumoniae and E. coli
Shows better antimicrobial activity than Gentamicin and Amikacin sulfate in vitro
Demonstrates significant in vivo efficacy in M. tuberculosis infection models
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IWP-O1 is a small-molecule porcupine (PORCN) inhibitor used in research to block Wnt protein secretion and signaling. It demonstrates high potency in cell-based assays and suppresses phosphorylation of downstream signaling proteins, making it useful as a tool compound for Wnt pathway studies.
Potent porcupine (PORCN) inhibitor; EC50 ~80 pM in L-Wnt-STF cells.
Inhibits Wnt protein secretion and downstream signaling in cell-based assays.
Suppresses phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
High reported purity of 99.8%.
Molecular formula C26H20N6O; molecular weight 432.48 g·mol-1.
Store protected from light at 4°C; in solvent, -80°C (6 months) or -20°C (1 month).
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HMP Linker is an acid-sensitive linker used in solid-phase peptide synthesis (SPPS) It is designed to facilitate the covalent attachment of peptide carboxy-terminal residues to solid-phase resin supports and enables controlled cleavage of synthesized peptides under mildly acidic conditions thereby preserving the structural integrity of sensitive functional groups and peptide termini HMP Linker acts primarily by hydrolyzing upon acid catalysis which allows the intact release of peptides from resin supports Based on these properties HMP Linker holds research potential in peptide therapeutics synthesis and studies requiring mild peptide cleavage conditions
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L-Inosine is the L-configuration of Inosine, an endogenous purine nucleoside produced by catabolism of adenosine. It exhibits a range of biological activities.
Anti-inflammatory effects
Antinociceptive effects
Immunomodulatory effects
Neuroprotective effects
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AGL-2263 is a novel and potent inhibitor of both the insulin receptor (IR) and the insulin-like growth factor (IGF) receptor. It appears as a light yellow to yellow solid powder and is intended for research use only, not for human or veterinary use.
Inhibits the insulin receptor (IR) and insulin-like growth factor (IGF) receptor.
Available as a light yellow to yellow solid powder.
Stable at ambient temperature for ordinary shipping.
Soluble in DMSO (~100 mg/mL) and various formulations.
Demonstrates biological activity in vitro by inhibiting IR.
Can still allow insulin to phosphorylate ERK1/2 and AKT in some cellular contexts.
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