Carbohydrates
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.5% | 568.53 | 25 MG
SN-38 glucuronide (SN-38G) is an inactive metabolite of Irinotecan, an anticancer active molecule, and has toxic effects on the gastrointestinal tract. Irinotecan functions as a topoisomerase I inhibitor and is utilized in research related to colon and rectal cancer.
- Cells capable of metabolizing SN-38 to SN-38G show increased resistance to extracellular SN-38.
- Can serve as a substrate for gut microbial β-glucuronidase enzymes.
- These enzymes remove the glucuronic acid moiety, which reactivates SN-38.
- Reactivation of SN-38 in the intestine can intensify its toxic effects on the gut.
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 25mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097080.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 25mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000093078.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 10mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
Medchemexpress LLC Knt-127 | 1256921-89-7 | 99.6% | 10 MG
KNT-127 is a selective δ-opioid receptor agonist used in neuroscience research, reported to produce antidepressant-like and antinociceptive effects in preclinical models. CAS: 1256921-89-7. It is supplied as an off-white to light yellow solid with high purity and is suitable for in vitro and in vivo studies.
- Selective δ-opioid receptor agonist.
- Reported antidepressant-like and antinociceptive effects in animal models.
- High purity (99.6%).
- Molecular weight 372.46 g/mol.
- Soluble in DMSO at 25 mg/mL.
- Powder stable when stored at -20°C for extended periods.
- Suitable for in vitro pharmacology and in vivo behavioral studies.
- Available in small research quantities for laboratory use.
TARGETMOL CHEMICALS INC Rehmannioside D 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Rehmannioside D is a carotenoid glycoside that existed in the roots of Rehmannia glutinosa. Purity 98.67%
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | C106H162FN9O37 | 10 MG
OBI-992 drug-linker is an exatecan-based drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis. It links the TOP1 inhibitor exatecan to a cleavable linker to enable targeted delivery of the payload; preclinical studies report antitumor activity in mouse and PDX models. Supplied as a solid for research use, the product includes specified purity and storage recommendations for laboratory handling.
- Composed of exatecan linked to a cleavable linker.
- Demonstrated antitumor activity in preclinical models.
- High molecular weight compound suitable for ADC synthesis.
- Provided as a white to yellow solid.
- Purity 96.6%.
- Molecular weight 2173.46.
- Storage: sealed, away from moisture and light; in solvent -80°C for 6 months, -20°C for 1 month.
- Supplied in a 10 mg package for research use.
Medchemexpress LLC D-α-hydroxyglutaric acid disodium | 103404-90-6 | 98.0% | 192.08 | C5H6Na2O5 | 10 MG
D-α-hydroxyglutaric acid disodium is the disodium salt of the R-enantiomer of 2-hydroxyglutaric acid, supplied as a solid research reagent and biochemical standard for studies of D-2-hydroxyglutaric acid metabolism and α-ketoglutarate-dependent enzyme activity. Typical properties: C5H6Na2O5, Mw 192.08, CAS 103404-90-6.
- High purity suitable for research applications (>98%).
- Disodium salt form for improved aqueous solubility.
- Useful as a biochemical standard in metabolic and enzyme studies.
- Reported to modulate ATP synthase activity and increase ROS in biochemical assays.
- Stable when stored sealed away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Integrin alpha V bet 50ug | 50ug
Integrin alpha V beta 3 (ITGAV ITGB3) functions as a receptor for CD40LG enhancing Lilrb4a inhibitory effects on mast cell activation It suppresses marginal zone B cell antibody production through Lilrb4a interaction ITGAV ITGB3 forming a heterodimer with ITGAV interacts with ligands such as RAB25 CIB1 FBLN5 and more It also forms a complex with PTPRZ1 and PTN stimulating endothelial cell migration Integrin alpha V beta 6 Protein Mouse (HEK293 His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 6 Protein Mouse (HEK293 His) has molecular weight of 90-140 kDa