Carbohydrates
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.5% | 568.53 | 25 MG
SN-38 glucuronide (SN-38G) is an inactive metabolite of Irinotecan, an anticancer active molecule, and has toxic effects on the gastrointestinal tract. Irinotecan functions as a topoisomerase I inhibitor and is utilized in research related to colon and rectal cancer.
- Cells capable of metabolizing SN-38 to SN-38G show increased resistance to extracellular SN-38.
- Can serve as a substrate for gut microbial β-glucuronidase enzymes.
- These enzymes remove the glucuronic acid moiety, which reactivates SN-38.
- Reactivation of SN-38 in the intestine can intensify its toxic effects on the gut.
Apexbio Technology LLC β-Pompilidotoxin 216064-36-7 10mg
-Pompilidotoxin ( -PMTX CAS 216064-36-7) is a peptide neurotoxin isolated from the venom of the solitary wasp Batozonellus maculifrons Composed of 13 amino acids (C71H124N22O17) -PMTX modulates neuronal excitability by selectively slowing the inactivation of voltage-gated sodium (Na ) channels without affecting cardiac Na channels This action is thought to involve interaction with neurotoxin receptor site 3 on the extracellular surface of neuronal Na channels Compared to -pompilidotoxin -PMTX exhibits greater potency in enhancing synaptic transmission at neuromuscular junctions -PMTX serves as a valuable tool for investigating Na channel kinetics and the molecular mechanisms regulating synaptic transmission
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 25mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097080.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 25mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000093078.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 10mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
Medchemexpress LLC Knt-127 | 1256921-89-7 | 99.6% | 10 MG
KNT-127 is a selective δ-opioid receptor agonist used in neuroscience research, reported to produce antidepressant-like and antinociceptive effects in preclinical models. CAS: 1256921-89-7. It is supplied as an off-white to light yellow solid with high purity and is suitable for in vitro and in vivo studies.
- Selective δ-opioid receptor agonist.
- Reported antidepressant-like and antinociceptive effects in animal models.
- High purity (99.6%).
- Molecular weight 372.46 g/mol.
- Soluble in DMSO at 25 mg/mL.
- Powder stable when stored at -20°C for extended periods.
- Suitable for in vitro pharmacology and in vivo behavioral studies.
- Available in small research quantities for laboratory use.
Medchemexpress LLC Egg oil | 8001-17-0 | 25 MG
Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation.
- Reduces IL-8 secretion, demonstrating anti-inflammatory efficacy.
- Protects against neurodegenerative diseases by attenuating cytotoxicity and modulating antioxidant enzymes.
- Maintains cell viability in Caco2 cells.
- Improves insulin sensitivity and hepatic glycogen synthesis, alleviating insulin resistance.
- Ameliorates HFD-induced obesity, restoring gut microbial balance and down-regulating the LPS/TLR4 pathway.
- Reduces body weight, adipose weight gain, blood glucose, and lipids in mice.
- Increases mRNA levels of key signaling proteins in muscle and liver.
eMolecules 526-07-8 | Medchem Express | Sesamolin | 5mg | 582658843 | HY-N0809 | MFCD04112844 | 370.357 | C20H18O7
Medchem Express | Sesamolin | 5mg | 582658843 | HY-N0809 | 526-07-8 | MFCD04112844 | 370.357 | C20H18O7
Medchemexpress LLC 4-Methylumbelliferyl β-D-galactopyranoside | 6160-78-7 | MFCD00036773 | 99.1% | 338.31 | 250 MG
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase. When cleaved, it produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer.
- Fluorescent substrate for β-galactosidase
- Produces a blue fluorescent coumarin fluorophore upon cleavage
- Fluorophore detectable by fluoroenzymeter or fluorometer
- Purity: 99.06%
- Molecular weight: 338.31
- Chemical formula: C16H18O8
- Appearance: Solid, white to off-white
- Emission (Em): 480; Excitation (Ex): 390
- Solubility: 41.67 mg/mL in DMSO
- Shipping: Room temperature
- Storage: -20°C (solid); -80°C (6 months) or -20°C (1 month) in solvent, protect from light
Medchemexpress LLC Integrin alpha V bet 20ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 8 Protein Human (HEK293 His solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 8 Protein Human (HEK293 His solution) has molecular weight of 187 95 kDa