D-GsMTx4 is a spider peptide, serving as the D enantiomer of GsMTx4. It functions as an inhibitor of the mechanosensitive ion channel Piezo2, effectively reducing [Ca2+]i elevation and modulating the mTOR and PI3K-Akt signaling pathways. This peptide has shown to inhibit mechanical allodynia and thermal hyperalgesia, making it a valuable tool for research into conditions such as mechanical stress, chronic pain, and idiopathic pulmonary fibrosis.
- Inhibits Piezo2-mediated mechanosensitive inward currents
- Decreases phosphorylation levels in mTOR and PI3K-Akt pathways
- Inhibits mechanical stimulation-evoked [Ca2+]i increases
- Reduces mechanical allodynia and thermal hyperalgesia