Carbohydrates
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.49% | 568.53 | 50 MG
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor used for researching colon and rectal cancer. SN38-G is the glucuronidated metabolite of SN38. Cells with the ability to metabolize SN38 to SN38-G are more resistant to extracellular SN38 than cells lacking this capability. SN-38 glucuronide can also serve as a substrate for gut microbial β-glucuronidase enzymes, which remove the glucuronic acid moiety to reactivate SN-38, thereby increasing its toxic effects on the gut.
- For research use only.
![Alkali Scientific 4 Methylumbelliferyl α D Galactopyranoside Monohydrate [4 Methylumbelliferyl α D Galactoside], 100 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661164.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl α D Galactopyranoside Monohydrate [4 Methylumbelliferyl α D Galactoside], 100 Milligrams
Methylumbelliferyl Galactopyranoside is a high-purity reagent widely used in biochemical analysis, especially in assays targeting galactosidase enzymes. This 100mg reagent is commonly employed in studies of lactose metabolism and in enzymatic assays that involve the hydrolysis of galactose-containing substrates. It is especially useful in clinical research, microbiology, and biochemistry for studying the breakdown of complex carbohydrates. This reagent is essential in enzyme-linked assays, enzyme activity screening, and metabolic research focusing on galactose or lactose metabolism, providing valuable data on enzyme kinetics and activity.
Medchemexpress LLC PROTAC BET degrader- 1mg | 3031993-61-7 | 1 MG
PROTAC BET degrader-3 is a proteolysis-targeting chimera that links a von Hippel-Lindau (VHL) ligand to a BET ligand to induce targeted proteasomal degradation of BET proteins. It is supplied as a light-yellow solid for research use.
- Induces VHL-mediated degradation of BET proteins.
- Molecular formula C53H64N12O9S; molecular weight 1045.22 g·mol⁻¹.
- Reported purity 99.11%.
- Available in small milligram quantities for screening and cell-based studies.
- Store powder at -20°C; in solution store at -80°C for long term.
Medchemexpress LLC PROTAC BET degrader-1 | 2093386-22-0 | 99.4% | 871.9 g/mol | C44H45N11O9 | 100 MG
PROTAC BET Degrader-1 is a proteolysis-targeting chimera (PROTAC) that links Cereblon and BET ligands to promote ubiquitin-mediated degradation of BET family proteins BRD2, BRD3, and BRD4 at low concentrations. It is supplied for research use in studies of BET protein biology and targeted protein degradation.
- Induces degradation of BRD2, BRD3, and BRD4 at low nanomolar concentrations.
- High purity (99.4%) suitable for biochemical and cell-based assays.
- Available as solid or as DMSO solution for experimental flexibility.
- High solubility in DMSO (≥ 50 mg/mL) for convenient dosing.
- Stable when stored per manufacturer recommendations for long-term experiments.
Medchemexpress LLC Integrin alpha 5 bet 5ug
ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin fibrinogen PLA2G2A fibrillin-1 (FBN1) IL1B human metapneumovirus and soluble CD40LG ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites Integrin alpha 5 beta 1 Protein Human (HEK293 Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein expressed by HEK293 with C-Flag C-10 His labeled tag Integrin alpha 5 beta 1 Protein Human (HEK293 Flag-His) has molecular weight of 101 35 kDa