RK-701 is a highly selective and non-genotoxic inhibitor of G9a, with an IC50 value of 23-27 nM. It selectively up-regulates HbF, γ-Globin, and BGLT3 expression, while down-regulating H3K9me2 expression. RK-701 also inhibits BCL11A and ZBTB7A, and is intended for research use only.
- Highly selective G9a inhibitor
- Non-genotoxic compound
- Potent inhibition with IC50 value of 23-27 nM for G9a
- Up-regulates HbF, γ-Globin, and BGLT3 expression
- Down-regulates H3K9me2 expression
- Inhibits BCL11A and ZBTB7A
- Low toxicity observed in in vivo studies