Lipids and Lipid Derivatives
Chem-Impex International, Inc. Dehydroepiandrosterone | MFCD00003613 | 5G
Dehydroepiandrosterone, MFCD00003613, 5G
TARGETMOL CHEMICALS INC Cucurbitacin IIA 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3. Purity 98.62%
Cayman Chemical 2-chloro PalmItIc AcId 1mg
A monochlorinated form of palmitic acid; produced in an MPO- and time-dependent manner in neutrophils stimulated by PMA; induces NETosis in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with ecDNA, and trapping of E. coli at 10 μM; increases COX-2 protein levels in HCAECs at 50 μM; increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, at 10 μM; induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells at 10-50 μM
Apexbio Technology LLC 2-hexyl-4-Pentynoic Acid 96017-59-3 10mM (in 1mL DMSO)
2-hexyl-4-Pentynoic Acid (CAS 96017-59-3) is a valproic acid derivative that functions as a histone deacetylase (HDAC) inhibitor exhibiting an IC50 of 13 M HDACs regulate gene expression by removing acetyl groups from histones promoting chromatin condensation and transcriptional repression In cerebellar granule cells 2-hexyl-4-Pentynoic Acid increases acetylated histone H3 levels in a dose-dependent manner and enhances HSP70-1a/1b mRNA expression At 50 100 M it significantly elevates Ac-H3 levels beyond those achieved with valproic acid and provides complete protection against glutamate-induced cell death indicating its utility in neuroprotection and epigenetic research
Chem-Impex International, Inc. Dehydroepiandrosterone | MFCD00003613 | 100G
Dehydroepiandrosterone, MFCD00003613, 100G
Medchemexpress LLC TNF-alpha/TNFSF2 Cy 50ug
TNF-alpha/TNFSF2 protein binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR It induces tumor cell death fever cachexia cell proliferation and cell differentiation It also causes insulin resistance and GKAP42 protein degradation in adipocytes Additionally it plays a role in angiogenesis osteoclastogenesis and IL12 production in dendritic cells TNF-alpha/TNFSF2 Protein Cynomolgus (N-His) is the recombinant cynomolgus-derived TNF-alpha/TNFSF2 protein expressed by E coli with N-6 His labeled tag
Cambridge Isotope Laboratories 1-Myristoyl-2-lyso-SN-glycero-3-phosphoglycerol NH4 (myristoyl-D27 97% 50-60% on Alpha carbon) 0 1 g
1-Myristoyl-2-lyso-SN-glycero-3-phosphoglycerol NH4 (myristoyl-D27 97% 50-60% on Alpha carbon) 0 1 g
Medchemexpress LLC Seglitide acetate | 99248-33-6 | 99.3% | 869.02 g/mol | C46H60N8O9 | 1 MG
Seglitide acetate is a cyclic somatostatin analog peptide used as a research reagent to probe somatostatin receptor pharmacology, including SSTR2-mediated signaling and metabolic effects. Provided as the acetate salt in small, research-scale quantities, it is intended for laboratory use only.
- Somatostatin receptor 2 (SSTR2) agonist for receptor pharmacology studies.
- Cyclic peptide provided as the acetate salt.
- High purity: 99.3% (HPLC).
- Molecular weight: 869.02 g/mol; formula C46H60N8O9.
- Supplied in research sizes (1 mg-100 mg).
- Accompanying analytical documentation: datasheet, COA, RP-HPLC, MS, elemental analysis, SDS.
Apexbio Technology LLC nor-NOHA (acetate) 1140844-63-8 10mg
nor-NOHA (acetate) (CAS 1140844-63-8) is a potent reversible inhibitor of rat liver arginase (Ki 0 5 M) By competitively inhibiting arginase nor-NOHA modulates the cellular balance between the L-arginine-dependent pathways of nitric oxide synthase (NOS) and arginase affecting nitric oxide production and urea cycle metabolism In vitro studies have shown that nor-NOHA suppresses proliferation migration and invasion of HepG2 hepatocellular carcinoma cells induces apoptosis and alters expression of Arg1 MMP-2 P53 and ECD In vivo nor-NOHA improves endothelial function in rat models of inflammation by enhancing NOS activity increasing EDHF and reducing superoxide anion production This compound is widely used to investigate arginase-related mechanisms in cellular and vascular biology
Medchemexpress LLC TNF-alpha/TNFSF2 Cy 10ug | 10ug
Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Cynomolgus (Biotinylated) is a biotinylated recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E coli
Cambridge Isotope Laboratories cis-5 8 11 14 17-Eicosapentaenoic acid (unlabeled) 1 mg
cis-5 8 11 14 17-Eicosapentaenoic acid (unlabeled) 1 mg
Cayman Chemical Estrone Steroid Hormones
A primary, naturally-occurring estrogen; serum concentrations in premenopausal women fluctuate according to the menstrual cycle; becomes the most predominant estrogen in postmenopausal women; binding affinities to ERα and ERβ are ~60% and ~37% relative to estradiol