Nucleosides and Analogues
Medchemexpress LLC N6-Isopentenyladenosine | 7724-76-7 | 99.4% | 335.36 | 1 ML
N6-Isopentenyladenosine (Riboprine) is an RNA modification found in cytokinins, which are known to regulate plant growth and differentiation. It is also present in a subset of tRNAs, where it enhances the efficiency and accuracy of translation. This compound is an end product of the mevalonate pathway and functions as an autophagy inhibitor, demonstrating interesting anti-melanoma activity.
- RNA modification found in cytokinins
- Regulates plant growth/differentiation
- Improves efficiency and accuracy of translation in tRNAs
- End product of the mevalonate pathway
- Autophagy inhibitor
- Exhibits anti-melanoma activity
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | MFCD00149364 | >99.8% | 269.26 | 100 G
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation, activates caspase-3, and promotes apoptosis. Additionally, it inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) and the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer. It is for research use only and not sold to patients.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3.
- Promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Medchemexpress LLC 2'-Deoxyadenosine-5'-triphosphate (trisodium), PCR grade | 54680-12-5 | PCR Grade | 557.13 | 1 ML
2'-Deoxyadenosine-5'-triphosphate trisodium, 100 mM solution, PCR Grade, is a nucleotide utilized by cells for DNA synthesis and replication. It serves as a raw material for DNA polymerase to synthesize long DNA strands and is also used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is supplied as an aqueous solution.
- Substrate for DNA polymerase
- Facilitates DNA synthesis and replication
- Suitable for reverse transcription polymerase chain reaction (RT-PCR)
- Aqueous solution format
Cayman Chemical 2-Fluoro-2-deoxyadenosIn 1g
A prodrug form of 2-F-adenine; reduces mean tumor weight in an E. coli purine nucleoside phosphorylase-expressing D54 glioblastoma mouse xenograft model at 100 mg/kg
Apexbio Technology LLC 2'-Deoxyguanosine 961-07-9 5g
2 -Deoxyguanosine (CAS 961-07-9) is a purine deoxyribonucleoside comprising guanine coupled to a deoxyribose moiety As an essential constituent of DNA it serves as a substrate in multiple nucleotide metabolism pathways Its interconversion with 2 -deoxyguanosine 5 -monophosphate is mediated by purine 5 -nucleotidase and deoxyguanosine kinase reflecting its role in nucleic acid turnover In biomedical research 2 -deoxyguanosine is utilized to study DNA synthesis repair mechanisms and enzymatic processes involving nucleoside metabolism Altered deoxyguanosine homeostasis has been implicated in purine nucleoside phosphorylase deficiency underscoring its significance in inherited metabolic disorders
Cambridge Isotope Laboratories 2-Deoxyguanosine H2O (13C10 98% 15N5 96-98%) 5 mg
2-Deoxyguanosine H2O (13C10 98% 15N5 96-98%) 5 mg
Sigma Aldrich Fine Chemicals Biosciences MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 5MG
MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 5MG
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 10 MM * 1 ML
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.
- Nucleoside analogue
- Can be incorporated into de novo-synthesized telomeres by telomerase
- Rapid cell death for the vast majority of cancer cell lines tested with IC50s of between 0.7-2.9 μM (in vitro)
- Causes a decrease of the tumor growth rate in A549 lung cancer cell-based mouse xenograft studies, superior to that observed with 6-thioguanine treatment (in vivo)
- Increases telomere dysfunction in tumor cells in vivo
- Appearance: Solid
- Color: White to yellow
Apexbio Technology LLC 2'-Deoxyguanosine 961-07-9 1g
2 -Deoxyguanosine (CAS 961-07-9) is a purine deoxyribonucleoside comprising guanine coupled to a deoxyribose moiety As an essential constituent of DNA it serves as a substrate in multiple nucleotide metabolism pathways Its interconversion with 2 -deoxyguanosine 5 -monophosphate is mediated by purine 5 -nucleotidase and deoxyguanosine kinase reflecting its role in nucleic acid turnover In biomedical research 2 -deoxyguanosine is utilized to study DNA synthesis repair mechanisms and enzymatic processes involving nucleoside metabolism Altered deoxyguanosine homeostasis has been implicated in purine nucleoside phosphorylase deficiency underscoring its significance in inherited metabolic disorders
Medchemexpress LLC Guanosine-1′-13C, 2′-deoxy-, monohydrate | 478511-26-1 | 99.9% | 286.25 | C913CH15N5O5 | 1 MG
2'-Deoxyguanosine-13C monohydrate is a 13C-labeled form of the nucleoside 2'-deoxyguanosine supplied as the monohydrate for analytical and research applications. It is intended for use as a stable-isotope internal standard, tracer, or reference material in mass spectrometry and metabolic studies. Certificate of analysis and safety data sheet are available for lot-specific purity and storage information.
- Isotope-labeled (13C) monohydrate suitable for analytical standards and tracing.
- High purity: 99.9% by HPLC, reported on the certificate of analysis.
- Supplied as a solid in small milligram quantities for laboratory use.
- Common applications include LC-MS/MS internal standard and metabolic labeling.
- Certificate of analysis and safety data sheet available for handling and storage instructions.
![eMolecules Medchem Express / Rp-cAMPS (sodium salt) / 1mg / 632433127 / HY-100530D / / 142439-94-9 / [null] / 367.250 / C10H11N5NaO5PS](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472106.JPG-250.jpg)
eMolecules Medchem Express / Rp-cAMPS (sodium salt) / 1mg / 632433127 / HY-100530D / / 142439-94-9 / [null] / 367.250 / C10H11N5NaO5PS
Medchem Express / Rp-cAMPS (sodium salt) / 1mg / 632433127 / HY-100530D / / 142439-94-9 / [null] / 367.250 / C10H11N5NaO5PS
Medchemexpress LLC Rp-cAMPS sodium salt | 142439-94-9 | 99.7% | 367.25 | C10H11N5NaO5PS | 5 MG
Rp-cAMPS sodium salt is a cAMP analog that competitively antagonizes cAMP-dependent protein kinase A (PKA) I and II and is resistant to hydrolysis by phosphodiesterases, intended for biochemical and cell signaling research applications.
- High purity (≈99.7%) suitable for biochemical assays.
- Molecular formula C10H11N5NaO5PS and molecular weight 367.25 g/mol.
- Resistant to hydrolysis by phosphodiesterases.
- Reported Ki values ~6.05 μM (PKA I) and ~9.75 μM (PKA II).
- Solid, white to pink appearance; available as solid or solution (10 mM in DMSO).
- Storage: -20°C sealed; in solvent -80°C (6 months) or -20°C (1 month).