Nucleosides and Analogues
Medchemexpress LLC 2'-Deoxycytidine-5'-monophosphoric acid-¹³C₉ (dilithium) | 99.5% | 328.00 | 1 MG
This product is 2'-Deoxycytidine-5'-monophosphate-¹³C₉ (dilithium), an isotopically labeled deoxycytidine monophosphate. It is provided as a colorless to light yellow solution at a concentration of 1 mg (70 mM in 43.55 μL Tris HCl/H₂O buffer pH=7.5). The compound is suitable for research applications requiring a high purity labeled standard.
- Isotopically labeled with ¹³C₉
- High purity of 99.5% (HPLC)
- Isotopic enrichment of 98.9%
- Provided in a solution format
- Recommended for storage at -20°C for up to 2 years
Medchemexpress LLC 2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 1 MG
2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 1 MG
Medchemexpress LLC Lamivudine | 134678-17-4 | 99.9% | 5 MG
Lamivudine is an analytical standard intended for research and analytical applications. It is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus. The salicylate form can penetrate the CNS.
- Analytical standard for research and analytical applications
- Inhibits HIV reverse transcriptase 1/2
- Inhibits hepatitis B virus reverse transcriptase
- Salicylate form can penetrate the CNS
- Commonly used in HPLC, GC, and MS research experiments
- For research use only
Medchemexpress LLC Adenosine | 58-61-7 | 99.96% | 100 G
Adenosine is an endogenous autacoid that acts through four G protein-coupled receptors (A1, A2A, A2B, and A3). It influences various cellular physiological processes. For research use only.
- Acts on A1, A2A, A2B, and A3 G protein-coupled receptors
- Influences neuronal activity, vascular function, platelet aggregation, and blood cell regulation
- Generated from ATP and AMP
- Antagonized by xanthines (e.g., caffeine)
- Exhibits cytotoxic effects at high concentrations
- Induces apoptosis and autophagy in cancer cells
- Inhibits cell viability and triggers ER stress
Medchemexpress LLC Glucosamine hydrochloride | 66-84-2 | 215.63 | 5 G
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, used as a dietary supplement. It is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, and when administered exogenously, it exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.
- Exhibits dose-dependent DPPH antioxidant activity
- Inhibits HIF-1α at the protein level and decreases phosphorylation of p70S6K and S6
- Significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin
Medchemexpress LLC Inosine-5'-diphosphate disodium | 54735-61-4 | 99.1% | 428.19 | 1 G
Inosine-5'-diphosphate disodium | 54735-61-4 | 99.1% | 428.19 | 1 G
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 10 MG
Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channels. It functions as an iron mobilizer by forming a complex with hepcidin, inhibiting the hepcidin-ferroportin (FPN) interaction and modulating the IL-6/Stat-3 pathway. This compound can ameliorate Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4, making it suitable for research on AI.
- Activates adenosine 5'-triphosphate-sensitive K+ channels.
- Functions as an iron mobilizer.
- Inhibits hepcidin-ferroportin (FPN) interaction.
- Modulates the IL-6/Stat-3 pathway.
- Ameliorates Turpentine-induced anemia of inflammation (AI) in mice.
- Suitable for research on anemia of inflammation.
Medchemexpress LLC 3′-Deoxyuridine | 7057-27-4 | 98.0% | 228.20 | 50 MG
3′-Deoxyuridine is a potential anticancer and antiviral agent, which inhibits bovine diarrhoea virus (BVDV) production.
- Potential anticancer agent
- Potential antiviral agent
- Inhibits bovine diarrhoea virus (BVDV) production
Medchemexpress LLC Uridine 5'-(trihydrogen diphosphate), sodium salt (1:x) | 21931-53-3 | 98.0% | 25 G
Uridine 5'-diphosphate sodium salt is an endogenous metabolite that acts as a potent and selective native agonist for the P2Y6 receptor (EC50=300 nM) and a potent antagonist for the P2Y14 receptor. It catalyzes the glucuronidation of various substrates and is crucial for nucleic acid (RNA) biosynthesis. For research use only.
- Potent and selective P2Y6 receptor agonist
- Potent P2Y14 receptor antagonist
- Catalyzes glucuronidation of various substrates
- Used in nucleic acid (RNA) biosynthesis
- Induces microglial CCL2 and CCL3 mRNA expression
- Activates NFATc1 and NFATc2 in microglia
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 10 MG
3′-Deoxyguanosine is a derivative of Guanosine that interacts with human purine nucleoside phosphorylase through hydrogen bonding. It demonstrates moderate displacement activity for [3H]-guanosine in rat meninges. This product is for research use only and not sold to patients.
- Derivative of guanosine
- Interacts with human purine nucleoside phosphorylase
- Useful for studying guanosine receptors
- Useful for studying purine metabolism
- Exhibits moderate displacement activity for [3H]-guanosine in rat meninges
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | MFCD28041154 | 97.0% | 267.25 | 100 MG
3′-Deoxyguanosine is a derivative of Guanosine. It interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. It exhibits moderate displacement activity for [3H]-guanosine in rat meninges and is useful for studying the mechanism of guanosine receptors and purine metabolism.
- Useful for studying guanosine receptors
- Used in research on purine metabolism
- Interacts via hydrogen bonding with human purine nucleoside phosphorylase
Medchemexpress LLC Uridine 5'-monophosphate disodium salt | 3387-36-8 | 99.9% | 368.14 | 5 G
Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. It can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
- Promotes late apoptosis in pig intestinal epithelial cells IPEC-J2.
- Promotes apoptosis and renewal of intestinal villus tip epithelial cells in pigs.
- Benefits gut development and and reduces diarrhea.
- Enhances the synthesis of CDP-choline in the brains of gerbils.
- Has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias.
eMolecules 990-91-0 | Tetrabenzyl Pyrophosphate | AA Blocks LLC | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Tetrabenzyl Pyrophosphate | AA Blocks LLC | 990-91-0 | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 25 MG
3′-Deoxyguanosine is a derivative of Guanosine. It interacts with human purine nucleoside phosphorylase through hydrogen bonding with residues like Glu201 and Asn243. This compound demonstrates moderate displacement activity for [3H]-guanosine in rat meninges and is useful for studying the mechanism of guanosine receptors and purine metabolism.
- Derivative of guanosine.
- Interacts with human purine nucleoside phosphorylase via hydrogen bonding.
- Exhibits moderate displacement activity for [3H]-guanosine in rat meninges.
- Useful for studying guanosine receptor mechanisms.
- Useful for studying purine metabolism.
- Displaces 50 nM [3H]-guanosine binding to rat brain membranes.
Medchemexpress LLC 3'-Deoxycytidine | 7057-33-2 | 98.0% | 227.22 | 5 MG
3'-Deoxycytidine (4-Amino-1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one) is a purine nucleoside analogue. These analogues demonstrate broad antitumor activity, specifically targeting indolent lymphoid malignancies. The anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis.
- Purine nucleoside analogue
- Broad antitumor activity targeting indolent lymphoid malignancies
- Anticancer mechanisms involve inhibition of DNA synthesis
- Induction of apoptosis