Nucleosides and Analogues
Medchemexpress LLC ATP-polyamine-biotin | 1800401-93-7 | 95.0% | 2 MG
ATP-polyamine-biotin is the first cell-permeable ATP analogue and an efficient kinase cosubstrate. It promotes biotin labeling of kinase substrates in live cells. In in vitro studies, when incubated with PKA kinase and full-length myelin basic protein (MBP) substrate, biotinylation was observed only in the presence of the kinase. The biotinylation of MBP was absent without this compound, in the presence of the kinase inhibitor staurosporine, or when incubated with acid, which causes cleavage of the phosphoramidate bond. A biotinylated kemptide product was observed exclusively with this cosubstrate.
- First cell-permeable ATP analogue
- Efficient kinase cosubstrate
- Promotes biotin labeling of kinase substrates in live cells
Medchemexpress LLC ATP dimagnesium | 74804-12-9 | 98.0% | 100 MG
ATP (Adenosine 5'-triphosphate) dimagnesium is a vital element in energy storage and metabolism within living organisms. It supplies the metabolic energy required for metabolic pumps and functions as a coenzyme in cells. Additionally, ATP dimagnesium acts as a significant endogenous signaling molecule involved in immunity and inflammation.
- A central component of energy storage and metabolism in vivo.
- Provides metabolic energy to drive metabolic pumps.
- Serves as a coenzyme in cells.
- An important endogenous signaling molecule in immunity and inflammation.
- For research use only.
Medchemexpress LLC Flavin adenine dinucleotide disodium salt | 84366-81-4 | MFCD08277021 | >94.0% | 829.51 g/mol | C27H31N9Na2O15P2 | 10 MG
Flavin adenine dinucleotide (FAD) disodium salt is the disodium salt form of FAD, a redox cofactor and prosthetic group for flavoproteins involved in cellular metabolism. Supplied as a solid for research and analytical applications, it is commonly used in enzymology, redox assays, and biochemical studies.
- Redox cofactor for flavoproteins and enzymatic reactions.
- Suitable for research and analytical applications.
- Available in small pack sizes for laboratory use.
- Stable when stored sealed, away from moisture and light.
- Well-characterized: CAS 84366-81-4; molecular weight 829.51 g/mol.
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | MFCD16627994 | 100.0% | 681.49 g·mol^-1 | C26H32F3N3O11P2 | 10 MG
Sonidegib diphosphate is the diphosphate salt of sonidegib, a potent and selective Smoothened (Smo) antagonist used in research to inhibit Hedgehog pathway signaling. It shows low-nanomolar binding potency in Smo assays and is supplied for laboratory use with supporting datasheet and safety documents.
- Potent Smo antagonist with low-nanomolar binding (mouse 1.3 nM; human 2.5 nM).
- Diphosphate salt form suitable for aqueous assay conditions.
- Supplied as a 10 mg vial for research use.
- Molecular weight 681.49 g·mol^-1; formula C26H32F3N3O11P2.
- Storage: sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Cambridge Isotope Laboratories Nicotinamide adenine dinucleotide (NAD⁺), NH₄⁺ salt (ribose-¹³C₅, 98%) CP 96%, 1 mg
Molecular Weight- 685.42Chemical Purity- 95%Form- IndividualConcentration- NeatApplication(s)- Biomolecular NMR, Genetic TherapyStorage Temp- Store in freezer (-20°C). Protect from light.
Sigma Aldrich Fine Chemicals Biosciences beta Nicotinamide adenine100MG
beta Nicotinamide adenine100MG
Sigma Aldrich Fine Chemicals Biosciences beta-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate | 698999-85-8 | MFCD00150480 | 100MG
beta-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate | Purity: >=98% (HPLC); >=98% (spectrophotometric assay) | 698999-85-8 | MFCD00150480 | 100MG
Medchemexpress LLC 2'-Deoxyguanosine-13C10,15N5 (monohydrate) | 2483830-26-6 | 99.8% | 5 MG
2'-Deoxyguanosine-13C10,15N5 (monohydrate) is the 13C and 15N labeled 2'-Deoxyguanosine monohydrate. It is an endogenous metabolite.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Apexbio Technology LLC Lamivudine 134678-17-4 50mg
Lamivudine is a nucleoside analog that acts primarily as a reverse transcriptase inhibitor disrupting viral replication by interfering with RNA-dependent DNA polymerase activity It inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with an IC50 value of approximately 0 316 M Lamivudine also suppresses replication of simian retrovirus (SRV-1 and SRV-2) while exhibiting negligible activity on foamy viruses and amphotropic murine leukemia virus (MLV-A) Due to its antiviral mechanism and dual inhibitory effect against both HIV-1 and hepatitis B virus (HBV) lamivudine is frequently utilized in research involving retroviral infection models particularly HIV-1 and HBV coinfection studies to evaluate viral dynamics antiviral efficacy and biochemical responses
Medchemexpress LLC Guanosine 5'-triphosphate (trisodium salt) | 36051-31-7 | 95.0% | 1 G
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. It can promote myogenic cell differentiation by upregulating miRNA and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. It holds promise for research in biosynthesis and skeletal muscle regeneration.
- Is a G protein signaling activator
- Is a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA
- Can promote myogenic cell differentiation
- Upregulates miRNA (miR133a, miR133b) and myogenic regulatory factor expression
- Induces human myogenic precursor cells to release exosomes containing guanosine molecules
- Holds promise for research in biosynthesis and skeletal muscle regeneration
- For research use only
Medchemexpress LLC BRM/BRG1 ATP Inhibitor-2 | 2368900-77-8 | 99.7% | C₂₀H₂₀N₄O₂S₂ | 25 MG
BRM/BRG1 ATP Inhibitor-2 is a BRG1/BRM ATPase inhibitor for the research of BAF-related disorders. This product is intended for research use only and not for sale to patients.
- BRG1/BRM ATPase inhibitor
- Used for research of BAF-related disorders
- Targets epigenetic reader domain
- Involved in epigenetics pathway
Selleck Chemical LLC BRM/BRG1 ATP Inhibitor-1
BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0 005 M
eMolecules 1094-61-7 | ??-Nicotinamide mononucleotide | Ambeed | MFCD00038748 | 334.221 | C11H15N2O8P | 97.000 | NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O | 250mg | 525183199
??-Nicotinamide mononucleotide | Ambeed | 1094-61-7 | MFCD00038748 | 334.221 | C11H15N2O8P | 97.000 | NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O | 250mg | 525183199