Nucleosides and Analogues
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | >98.0% | 569.44 | C22H29N5O9P2 | 50 MG
Motesanib diphosphate is the diphosphate salt of motesanib, an ATP-competitive small-molecule inhibitor of VEGF receptors used as a research reagent for kinase and signaling studies.
- ATP-competitive inhibitor of VEGFR1/2/3 with low-nanomolar potency.
- Diphosphate salt form improves aqueous solubility for in vitro applications.
- Molecular weight 569.44; formula C22H29N5O9P2.
- High solubility in DMSO (≥110 mg/mL) and moderate solubility in water (≈5 mg/mL with warming).
- Intended for research and analytical use; not for human or clinical use.
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 5 MG
Motesanib diphosphate is the diphosphate salt of motesanib, an ATP-competitive inhibitor of VEGFR1/2/3 and c-Kit, supplied for laboratory research and analytical applications.
- Potent ATP-competitive inhibitor of VEGFR1/2/3 and c-Kit.
- Molecular formula: C22H29N5O9P2.
- Molecular weight: 569.44 g/mol.
- Pack size: 5 mg.
- Solubility: DMSO ≥ 110 mg/mL; H2O 5 mg/mL (with ultrasonic warming).
- Storage: 4°C sealed; in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC Adenosine 5'-O-(2-thiodiphosphate) trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | C10H12Li3N5O9P2S | 10MG
ADP-β-S trilithium is the trilithium salt of adenosine 5'-β-thiodiphosphate, used in research as a P2Y12 receptor activator. It is supplied as a white to off-white solid (CAS 73536-95-5) with listed purity ~94.9% and molecular formula C10H12Li3N5O9P2S. Store sealed and away from moisture; in solution store at -80°C for long-term stability.
- Activator of P2Y12 receptor in cellular assays.
- Upregulates IL-1β and IL-6 production in microglial models.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation in relevant studies.
- Provided as a solid suitable for preparation of assay solutions.
- Stable under recommended sealed, low-temperature storage conditions.
Medchemexpress LLC Adenosine 5'-β-thiodiphosphate trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | 461.07 g·mol⁻¹ | C10H12Li3N5O9P2S | 5 MG
ADP-β-S trilithium is the trilithium salt form of adenosine 5'-β-thiodiphosphate used as a research reagent to activate P2Y12 receptors and study purinergic signaling and inflammatory pathways. It modulates cytokine production and NF-κB/NLRP3 signaling, and is provided as a dry powder for laboratory use.
- Activates P2Y12 receptor to modulate purinergic signaling.
- Increases IL-1β and IL-6 production in microglial cells.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation.
- Supplied with stated purity and molecular data for experimental planning.
- Suitable for biochemical and cellular assays requiring receptor activation.
Medchemexpress LLC Uridine 5'-(trihydrogen diphosphate), 4-oxime | 39023-73-9 | 98.8% | 419.18 | 10 MG
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in a diphosphate form. NHC is a pyrimidine ribonucleoside and acts as a potent anti-virus agent, effectively inhibiting the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV).
- Active phosphorylated intracellular metabolite
- Potent anti-virus agent
- Inhibits replication of Venezuelan equine encephalitis virus (VEEV)
- Inhibits replication of Chikungunya virus (CHIKV)
- Inhibits replication of hepatitis C virus (HCV)
- For research use only
- Soluble in H2O: 160 mg/mL (needs ultrasonic)
- Store at -20°C, protect from light, stored under nitrogen
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 100mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
eMolecules 990-91-0 | Tetrabenzyl Pyrophosphate | AA Blocks LLC | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Tetrabenzyl Pyrophosphate | AA Blocks LLC | 990-91-0 | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.9% | 681.49 | 50 MG
Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist that reduces the expression of downstream Hedgehog (Hh) signaling targets. It demonstrates dose-related antitumor activity in various preclinical models and is currently undergoing clinical trials for conditions such as Basal Cell Carcinoma and Hepatocellular Carcinoma.
- Potent and selective Smoothened (Smo) antagonist
- Reduces expression of downstream Hedgehog (Hh) signaling targets
- Inhibits Hh pathway in CD34+ chronic phase (CP)-chronic myeloid leukaemia (CML) cells
- Demonstrates dose-related antitumor activity in medulloblastoma models
- Undergoing clinical trials for various conditions
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
TARGETMOL CHEMICALS INC ADENOSINE ANTAGONIST-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine antagonist-1 acts as an adenosine A3 receptor (AA3R) antagonist. purity: 99%
Medchemexpress LLC Tenofovir diphosphate disodium | 2738719-07-6 | 99.42% | 491.14 | 1 MG
Tenofovir diphosphate disodium is an antiretroviral agent primarily used for AIDS research. It acts as an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). This compound exhibits minimal inhibitory effect on eukaryotic DNA replication in vitro.
- Antiretroviral agent
- Inhibits HIV reverse transcriptase DNA and RNA
- Used for AIDS research
- Minimal inhibitory effect on eukaryotic DNA replication in vitro
Medchemexpress LLC Cidofovir diphosphate tri(triethylamine) | 00-00-0 | 99.9% | 742.72 g/mol | C26H61N6O12P3 | 5 MG
Cidofovir diphosphate tri(triethylamine) is the triethylamine salt of cidofovir diphosphate, an active intracellular metabolite and selective inhibitor of viral DNA polymerases. It is provided as a high-purity biochemical reagent intended for in vitro and biochemical research applications.