Chromatography Standards
Sigma Aldrich Fine Chemicals Biosciences Candelilla wax United States Pharmacopeia (USP) Reference Standard | 8006-44-8 | MFCD00146289 | 250MG
Candelilla wax United States Pharmacopeia (USP) Reference Standard | 8006-44-8 | MFCD00146289 | 250MG
Cayman Chemical Mirabegron Impurity 6, Purity: ≥95%, CAS: 391901-45-4, 500 mg
A metabolite of mirabegron; formed via hydrolysis of mirabegron by BChE; an intermediate in the synthesis of mirabegron
Apexbio Technology LLC Oprozomib (ONX-0912) 935888-69-0 25mg
Oprozomib (ONX-0912 CAS 935888-69-0) is an orally bioavailable small-molecule inhibitor of the proteasome structurally related to carfilzomib It targets predominantly the chymotrypsin-like proteolytic activity of the proteasome inducing apoptosis and growth inhibition in multiple myeloma (MM) cell lines including those resistant to bortezomib In preclinical models oprozomib activates pro-apoptotic pathways involving caspases-3 -8 -9 as well as PARP cleavage suppresses angiogenesis and tumor cell migration thereby reducing tumor progression and prolonging survival Its biological activity positions oprozomib as a promising compound for MM research
Apexbio Technology LLC Acarbose 56180-94-0 2g
Acarbose (CAS 56180-94-0) is a small-molecule inhibitor targeting intestinal -glucosidase an enzyme involved in carbohydrate digestion It exerts its pharmacological action by hindering the hydrolytic breakdown of complex carbohydrates into monosaccharides thereby slowing glucose absorption Demonstrating potent inhibitory activity with an IC of approximately 11 nM acarbose is widely explored in biomedical research contexts related to glucose regulation and diabetes management
Medchemexpress LLC Diphenhydramine hydrochloride | 147-24-0 | 99.93%
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist exhibiting anti-cholinergic effects. This compound is capable of crossing the ovine blood-brain barrier.
- Inhibits cisplatin-induced cell death in kidney proximal tubular cells.
- Inhibits cell viability in CCRF-CEM and Jurkat cells.
- Induces apoptosis in CCRF-CEM and Jurkat cells.
- Increases expression of Bad and Bax, and decreases BCL-2 level in PANC-1 cells.
- Decreases expression of various phosphorylated proteins (p-AKT, p-mTOR, p-FoxO1, p-MDM2, p-NF-ĸB p65, and p-GSK-3) in PANC-1 cells.
- Inhibits cisplatin-induced kidney toxicity in mice.
- Reduces mortality in rats with acute, severe dichlorvos exposure.
Medchemexpress LLC CPD-10 | 3055471-57-0 | 96.7% | 888.07 | 1 MG
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. It shows anti-proliferation and induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, and P-Rb(5807/811) in a dose-dependent manner.
- Potent CCND1 and CDK4 PROTAC degrader
- Shows anti-proliferation
- Induces apoptosis
- Decreases protein expression of cyclin D1, cyclin D3, CDK4, P-Rb(5807/811) in a dose-dependent manner
Medchemexpress LLC Benzeneacetamide, 4-butoxy-N-hydroxy- | 2438-72-4 | 98.0% | 500 MG
Bufexamac is a selective IIb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, demonstrating Kds of 0.53 μM for HDAC6 and 0.22 μM for HDAC10. It also functions as a nonsteroidal anti-inflammatory drug, useful in various research applications.
- Selective dual inhibitor of HDAC6, HDAC10, and LTA4H.
- Functions as a nonsteroidal anti-inflammatory drug.
- Inhibits IFN-α secretion in peripheral blood mononuclear cells.
- Inhibits HDAC10 to block autophagic flux, enhancing tumor-specific toxicity of DNA damage-inducing drugs.
- Inhibits neutrophil chemotaxis via inhibition of LTA4H-mediated endogenous LTB4 biosynthesis.
- Ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.
Selleck Chemical LLC SRT1720 HCl 50mg 1001645-58-4
SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 ?M in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Leuprorelin European Pharmacopoeia (EP) Reference Standard | 53714-56-0 |
Leuprorelin European Pharmacopoeia (EP) Reference Standard | Mol Wt: 1209.4 | 53714-56-0 |
Medchemexpress LLC Diaveridine | 5355-16-8 | MFCD00057349 | 99.8% | 5 G
Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. It is intended for research use only.
- Dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM
- Functions as an antibacterial agent
- Exhibits strong bactericidal effect on S. typhimurium TA1535 at 10 μg/mL or more
- Causes a dose-dependent, significant increase in aberrant metaphases at 100 μg/mL
- Does not cause abnormal chromosome aberration at studied doses
- Does not produce significant changes in organ-to-body weight ratio
Sigma Aldrich Fine Chemicals Biosciences Neamine | 3947-65-7 | MFCD00023857 | 0.5 mg
Neamine | Mol Wt: 322.36 | 3947-65-7 | MFCD00023857 | 0.5 mg
Sigma Aldrich Fine Chemicals Biosciences Diphenhydramine N-oxide United States Pharmacopeia (USP) Reference Standard | 13168-00-8 | 25MG
Diphenhydramine N-oxide United States Pharmacopeia (USP) Reference Standard | Mol Wt: 307.82 | 13168-00-8 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Ergocalciferol United States Pharmacopeia (USP) Reference Standard | 50-14-6 | MFCD00166988 | 5X30MG
Ergocalciferol United States Pharmacopeia (USP) Reference Standard | Mol Wt: 396.65 | 50-14-6 | MFCD00166988 | 5X30MG
Sigma Aldrich Fine Chemicals Biosciences Atomoxetine for impurity A identification European Pharmacopoeia (EP) Reference Standard | 82248-59-7 | MFCD06410992 |
Atomoxetine for impurity A identification European Pharmacopoeia (EP) Reference Standard | Mol Wt: 291.82 | 82248-59-7 | MFCD06410992 |
Sigma Aldrich Fine Chemicals Biosciences Dexketoprofen tromethamine United States Pharmacopeia (USP) Reference Standard | 156604-79-4 | 200MG
Dexketoprofen tromethamine United States Pharmacopeia (USP) Reference Standard | Mol Wt: 375.42 | 156604-79-4 | 200MG