Organometallic Compounds
Medchemexpress LLC Nh-bis(peg3-boc) | 1814901-03-5 | 98.0% | C26H51NO10 | 100 MG
This compound serves as a PEG-based linker for assembling Proteolysis Targeting Chimeras (PROTACs). PROTACs are designed with two distinct ligands connected by such a linker: one targets an E3 ubiquitin ligase, and the other binds to a specific target protein. This design enables PROTACs to leverage the cell's ubiquitin-proteasome system for the targeted degradation of proteins.
- Functions as a linker for PROTACs.
- Utilizes the ubiquitin-proteasome system.
- Enables targeted protein degradation.
eMolecules 77544-68-4 | Tos-PEG3 | Medchem Express (US) | MFCD18433414 | 304.360 | C13H20O6S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCO | 25g | 849371127
Tos-PEG3 | Medchem Express (US) | 77544-68-4 | MFCD18433414 | 304.360 | C13H20O6S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCO | 25g | 849371127
Medchemexpress LLC DPC-681 | 284661-68-3 | 99.72% | 669.85 | 50 MG
DPC-681 is a potent and selective inhibitor of HIV protease, effective against wild-type HIV-1. It is intended for research use only.
- Potent and selective inhibitor of HIV protease.
- Effective against wild-type HIV-1.
- Shows no loss in potency toward recombinant mutant HIVs with the D30N mutation.
- Fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions.
- Suitable for laboratory research applications.
eMolecules 2031-62-1 | Methyldiethoxysilane | Chem-Impex | MFCD00026749 | 134.250 | C5H14O2Si | 0.000 | CCO[SiH](C)OCC | 100g | 603116075
Methyldiethoxysilane | Chem-Impex | 2031-62-1 | MFCD00026749 | 134.250 | C5H14O2Si | 0.000 | CCO[SiH](C)OCC | 100g | 603116075
Medchemexpress LLC Azido-PEG3-C3-OH | 1807512-36-2 | 98.0% | C9H19N3O4 | 250 MG
Azido-PEG3-C3-OH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This click chemistry reagent features an Azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It also supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC M-PEG5-Br | 854601-80-2 | 98.0% | C11H23BrO5 | 10 G
m-PEG5-Br is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting the protein of interest. These compounds function by exploiting the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
Medchemexpress LLC NH2-PEG3 | 6338-55-2 | 149.19 | 100 G
NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker that belongs to the polyethylene glycol (PEG) linker family. It is used in the synthesis of PROTAC (β-NF-JQ1).
- PROTAC linker
- Can be used in the synthesis of PROTAC (β-NF-JQ1)
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g/mol | C10H21N3O5 | 25 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol (PEG) linker containing five ethylene glycol units that is used as a click-chemistry reagent and as a linker in bioconjugation workflows. It participates in copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions and is supplied for research use only.
- Azide functional group for click chemistry
- Five-unit PEG spacer adds hydrophilicity and flexibility
- Suitable for antibody-drug conjugate and PROTAC linker synthesis
- Characterized by NMR and LC-MS, purity >97.0%
- Available in multiple package sizes, including 25 G
Medchemexpress LLC I-PEG5-OH 1g
I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | >95.0% | 656.23 | C30H46ClN5O7S | 2 G
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a VHL E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in PROTAC development and related chemical biology research. It is a PEG3-linked derivative of the AHPC VHL ligand and is provided in multiple packaged sizes for synthesis and assay workflows.
- VHL E3 ligase ligand-linker conjugate suitable for PROTAC design.
- Provided as the hydrochloride salt for improved solubility and handling.
- Available in multiple sizes, including 2 G.
- Molecular formula C30H46ClN5O7S; molecular weight 656.23.
- Purity ≥95% by supplier specification.
Medchemexpress LLC m-PEG5-NH2 | 5498-83-9 | 99.0% | C11H25NO5 | 250 MG
m-PEG5-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules consisting of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These molecules function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only and not sold to patients.
- Purity: 99.02%
- Molecular weight: 251.32
- Formula: C11H25NO5
- CAS number: 5498-83-9
- Appearance: Liquid (density: 1.023±0.06 g/cm³)
- Color: Colorless to light yellow
- SMILES: COCCOCCOCCOCCOCCN
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Azido-PEG5-CH2CO2H | 217180-81-9 | 98.9% | 321.33 g/mol | C12H23N3O7 | 250 MG
Azido-PEG5-CH2CO2H is a cleavable, azide-functionalized polyethylene glycol (PEG) linker with a terminal carboxylic acid that provides a hydrophilic spacer and a reactive azide handle for bioconjugation and linker synthesis.
- Cleavable 5-unit PEG linker suitable for linker-based conjugation.
- Azide functional group for copper-catalyzed or strain-promoted click reactions.
- Terminal carboxylic acid enables further derivatization or coupling.
- Hydrophilic spacer increases solubility in aqueous media.
- High purity suitable for chemical synthesis and bioconjugation.
- Available in 250 MG pack size.
Medchemexpress LLC BCN-exo-PEG3-NH2 | 1841134-72-2 | >95.0% | C19H32N2O5 | 10MG
BCN-exo-PEG3-NH2 is a BCN-functionalized PEG3 amine linker used in bioorthogonal conjugation and PROTAC linker synthesis. It provides a strained alkyne handle and a terminal primary amine to enable modular coupling strategies, and is commonly supplied in research-scale quantities at high reported purity.
- Provides a strained alkyne (BCN) for rapid bioorthogonal click reactions.
- Contains a PEG3 spacer for flexibility and improved solubility.
- Features a terminal primary amine for amide or reductive amination conjugation.
- Suitable for linker construction in targeted degradation and bioconjugation workflows.
- Supplied in research-scale quantities with supplier-reported high purity.
Medchemexpress LLC NH2-PEG5-C6-Cl hydrochloride | 2241669-16-7 | 98.0% | 1 G
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Applicable in cancer and cancer targeted therapy research
- Classified as PROTAC linkers
Medchemexpress LLC Azido-PEG5-azide | 356046-26-9 | 99.98% | 332.36 | 500 MG
Azido-PEG5-azide is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
- For research use only