Organometallic Compounds
Medchemexpress LLC m-PEG3-azide | 74654-06-1 | MFCD00020141 | >98% | C7H15N3O3 | 250 MG
m-PEG3-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling it to participate in various cycloaddition reactions.
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne groups.
- Can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
Medchemexpress LLC Tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate | 252881-73-5 | 303.3547 g/mol | C13H25N3O5 | 50 MG
N3-PEG3-CH2CH2-Boc is an azido-terminated PEG3 linker with a tert-butyl (Boc) protected carboxylic acid end, used as a cleavable PEG-based linker in antibody-drug conjugate and PROTAC synthesis, and as an azide reagent for click chemistry.
- Azide-terminated PEG3 linker suitable for click chemistry.
- tert-Butyl (Boc) protected carboxyl end for orthogonal deprotection.
- Used in ADC and PROTAC linker assembly.
- Available as a small pre-weighed laboratory pack for synthetic use.
Medchemexpress LLC (S)-17-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-14-oxo-4,7,10-trioxa-13-azaoctadecane-1,18-dioic acid | 97.6% | C28H36N8O10 | 5 MG
Folate-PEG3-C2-acid is an acid fragment and PEG-type PROTAC linker used in the synthesis of Proteolysis-targeting Chimeras. It has a molecular weight of 644.63 and a purity of 97.56%.
- Stable under recommended storage conditions
- Consistent with structure based on 1H NMR Spectrum and LCMS
- Solid appearance
- For research use only
Medchemexpress LLC N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester | 2100306-76-9 | 95.0% | C30H54N6O11S | 100 MG
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker for the synthesis of PROTACs. It also functions as a click chemistry reagent, facilitating reactions with various alkyne-containing, DBCO, or BCN molecules.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC BocNH-PEG5-CH2CH2Br 250mg
BocNH-PEG5-CH2CH2Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Mal-PEG3-NH2 TFA | 2830214-77-0 | 99.1% | 386.32 g·mol⁻¹ | C14H21F3N2O7 | 10 MG
Mal-PEG3-NH2 TFA is a linear heterobifunctional polyethylene glycol crosslinker supplied as the trifluoroacetic acid (TFA) salt. It contains a maleimide group at one end and a primary amine at the other, enabling selective conjugation to thiols and amines. It is provided as a non-degradable (non-cleavable) linker commonly used in PROTAC and ADC linker design and general bioconjugation.
- Maleimide and primary amine functional groups for thiol and amine conjugation.
- Non-degradable, non-cleavable linker suitable for PROTAC and ADC applications.
- High reported purity of 99.07%.
- Molecular weight 386.32 g·mol⁻¹.
- Available in multiple sizes including 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg.
- Supplied as the trifluoroacetic acid (TFA) salt.
Medchemexpress LLC Lipoamide-PEG3-mal | 1314378-19-2 | 99.6% | C25H41N3O7S2 | 10MG
Lipoamide-PEG3-Mal is a PEG-based linker that combines a lipoamide (lipoic acid derivative) moiety with a terminal maleimide. It is supplied for research use as a building block in the synthesis of PROTACs and other bioconjugates, providing flexible spacing and a thiol-reactive handle for selective conjugation.
- Peg3 spacer provides flexibility and improved solubility.
- Lipoamide moiety offers a bio-relevant functional group for linkage.
- Maleimide group enables rapid and selective thiol conjugation.
- High reported purity suitable for synthetic applications.
- Available in small, research-friendly package sizes.
Medchemexpress LLC Bcn-peg3-oh | 2126749-77-5 | 99.6% | 369.45 | C19H31NO6 | 10 MG
BCN-PEG3-OH is a BCN-functionalized PEG linker used as a non-cleavable linker and click-chemistry reagent for bioconjugation and antibody-drug conjugate synthesis. It features a BCN group for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) and a three-unit PEG spacer terminating in a hydroxyl group.
- Non-cleavable PEG linker for ADC synthesis
- BCN group enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Three-unit PEG spacer with terminal hydroxyl
- High purity suitable for research applications
- Available in small pack sizes for laboratory use
eMolecules 1204669-57-7 | 3-(4-(2-AMINOETHYLAMINO)-1,2,5-OXADIAZOL-3-YL)-4-(3-BROMO-4-FLUOROPHENYL)-1,2,4-OXADIAZOL-5(4H)-ONE HI | AstaTech | MFCD27996217 | 513.066 | C12H11BrFIN6O3 | 95.000 | I.NCCNc1nonc1-c1noc(=O)n1-c1ccc(F)c(Br)c1 | 1g | 410712794
3-(4-(2-AMINOETHYLAMINO)-1,2,5-OXADIAZOL-3-YL)-4-(3-BROMO-4-FLUOROPHENYL)-1,2,4-OXADIAZOL-5(4H)-ONE HI | AstaTech | 1204669-57-7 | MFCD27996217 | 513.066 | C12H11BrFIN6O3 | 95.000 | I.NCCNc1nonc1-c1noc(=O)n1-c1ccc(F)c(Br)c1 | 1g | 410712794
Medchemexpress LLC Bis-PEG3-NHS ester | 1314378-16-9 | MFCD20227484 | 97.0% | 444.39 g·mol⁻¹ | C18H24N2O11 | 100 MG
Bis-PEG3-NHS ester is a noncleavable, three-unit polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester termini for amine coupling. It is intended for antibody-agent conjugation and related bioconjugation chemistries, enabling formation of stable amide bonds to primary amines on proteins or small molecules.
- Noncleavable three-unit PEG spacer suitable for antibody-agent conjugation and bioconjugation.
- Two NHS ester reactive termini for efficient amine coupling to primary amines.
- White to off-white solid, convenient for bench handling.
- High purity (97.0%) with CAS 1314378-16-9 and formula C18H24N2O11.
- Storage: powder at -20°C (stable up to 3 years); in solvent at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Biotin-PEG3-SS-azide | 2866429-93-6 | 99.6% | 692.91 | C27H48N8O7S3 | 10 MG
Biotin-PEG3-SS-azide is a cleavable three-unit polyethylene glycol linker bearing a biotin group and a terminal azide, designed for conjugation chemistry in research applications. It is suitable for click chemistry reactions and as a cleavable linker in the synthesis of antibody-drug conjugates.
- Cleavable disulfide linker provides intracellular release.
- Azide functionality enables CuAAC and strain-promoted cycloaddition.
- PEG3 spacer increases solubility and reduces steric hindrance.
- High purity supports reliable conjugation results.
- Soluble in DMSO at high concentration for in vitro use.
- Recommended storage at low temperature and protection from light to preserve stability.
Medchemexpress LLC M-PEG5-acid | 81836-43-3 | MFCD20926398 | 95.0% | 280.31 g/mol | C12H24O7 | 1 G
m-PEG5-acid is a monomethylated polyethylene glycol (PEG) linker terminated with a carboxylic acid group, used as a short spacer in the synthesis of PROTACs and other bioconjugates. It provides a PEG5 (approximately five ethylene oxide units) spacer with a reactive carboxylic acid for standard coupling chemistries.
- Short monomethylated PEG5 spacer with terminal carboxylic acid.
- Useful as a linker in PROTAC and conjugate synthesis.
- Molecular weight ~280.31 g/mol and formula C12H24O7.
- Typical purity around 95.0%.
- Light yellow to light brown liquid; density ~1.107 g/cm3.
- Store sealed, away from moisture; use cold storage for solutions.
eMolecules 252881-74-6 | NH2-PEG3-C2-Boc | Ambeed | MFCD06201017 | 277.361 | C13H27NO5 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN | 100mg | 506388578
NH2-PEG3-C2-Boc | Ambeed | 252881-74-6 | MFCD06201017 | 277.361 | C13H27NO5 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN | 100mg | 506388578
Medchemexpress LLC Bromoacetamido-PEG3-azide | 940005-81-2 | ≥97.0% | C10H19BrN4O4 | 50 MG
Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent containing an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups