Glycosyl compounds
![Medchemexpress LLC N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] | 1597403-47-8 | MFCD27952932 | 99.5% | 451.34 g/mol | C22H24Cl2N2O4 | 10MM 1ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235622.png-250.jpg)
Medchemexpress LLC N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] | 1597403-47-8 | MFCD27952932 | 99.5% | 451.34 g/mol | C22H24Cl2N2O4 | 10MM 1ML
ISRIB (trans-isomer) is a small-molecule inhibitor of the integrated stress response that potently inhibits PERK and reverses eIF2α phosphorylation. It is supplied as a 10 mM solution in DMSO or as solid quantities for use in biochemical and cellular assays; reported purity is 99.49% and molecular weight 451.34 g/mol.
- Potent PERK inhibition with reported IC50 of 5 nM.
- Reverses eIF2α phosphorylation in cellular assays.
- Available as 10 mM solution in DMSO and multiple solid sizes.
- High purity suitable for research applications.
- Molecular weight 451.34 g/mol and formula C22H24Cl2N2O4.
- Useful for biochemical and cell-based studies of the integrated stress response.
Cayman Chemical Matairesinol Fatty Acids and D
A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 UG/ml); increases the lifespan of C. elegans at 100 µM; reduces oxaliplatin-induced neurotoxicity in neural PC12 cells at 0.4, 2, and 10 µM; topical administration reduces EAr thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis at 50 UG/ear