Monosaccharides
Medchemexpress LLC Lometrexol disodium | 120408-07-3 | 98.0% | 487.42 | C21H23N5Na2O6 | 5 MG
Lometrexol disodium is an antipurine antifolate research compound that inhibits glycinamide ribonucleotide formyltransferase (GARFT) and serine hydroxymethyltransferase 1/2 (hSHMT1/2), disrupting de novo purine synthesis and leading to cell cycle arrest and apoptosis. It is supplied as a disodium salt for biochemical and cellular studies.
- Potent GARFT and hSHMT1/2 inhibitor used to study purine metabolism.
- High purity: 98.0% suitable for analytical and biological assays.
- Molecular formula C21H23N5Na2O6 and molecular weight 487.42.
- Provided as a solid powder in small research pack sizes for convenience.
- Documentation available: data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Piperaquine phosphate | 85547-56-4 | 98.6% | 100 MG
Piperaquine phosphate is a bisquinoline antimalarial agent. It can be utilized in antimalarial research in conjunction with Artemisinin.
- Acts as a bisquinoline antimalarial agent
- Used in antimalarial research with artemisinin
- Reduces parasitemia in mice
- Extends median survival time in animal models with Plasmodium berghei parasites
Medchemexpress LLC Cromolyn (disodium) | 15826-37-6 | 89.2% | 50 MG
Cromolyn disodium (Standard) is the analytical standard for Cromolyn disodium. It is designed for research and analytical applications. This compound acts as an orally active GSK-3β inhibitor with an IC50 of 2.0 μM, and it also functions as a mast cell stabilizer. It works by inhibiting the release of mediators from mast cells, regulating reflex bronchoconstriction, and reducing non-specific bronchial hyperreactivity, making it relevant for bronchial asthma research.
- Orally active GSK-3β inhibitor
- Mast cell stabilizer
- Inhibits mediator release from mast cells
- Regulates reflex bronchoconstriction
- Reduces non-specific bronchial hyperreactivity
- Anti-inflammatory, anti-allergic, anti-histamine effects
- Anti-cancer and neuroprotective effects
Medchemexpress LLC Lobenzarit (disodium) | 64808-48-6 | MFCD00941422 | 99.9% | 335.65 g/mol | C14H8ClNNa2O4 | 50 MG
Lobenzarit disodium (CCA) is an immunomodulatory research compound with reported anti-arthritic and antioxidative activity. It is used in preclinical in vitro and in vivo studies to investigate immune modulation and oxidative stress pathways; supplied as the disodium salt for improved solubility and handling. For research use only.
- Immunomodulator with reported anti-arthritic activity.
- Antioxidative properties useful in oxidative stress studies.
- Disodium salt form improves aqueous solubility and handling.
- Molecular weight 335.65 g/mol; formula C14H8ClNNa2O4.
- Suitable for preclinical in vitro and in vivo assays; for research use only.
Medchemexpress LLC K-Ras ligand-Linker Conjugate 4 | 2378261-83-5 | 98.8% | 25 MG
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for the K-Ras recruiting moiety and a PROTAC linker. This linker recruits E3 ligases such as VHL, CRBN, MDM2, and IAP. It can be used in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells. PROTACs consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates a ligand for the K-Ras recruiting moiety
- Includes a PROTAC linker that recruits E3 ligases (VHL, CRBN, MDM2, and IAP)
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Can be used in the synthesis of PROTAC K-Ras Degrader-1
- For research use only
Medchemexpress LLC D-xylulose 5-phosphate sodium | 105931-44-0 | MFCD00070073 | 90.0% | 252.09 g/mol | C5H10NaO8P | 10mg
D-Xylulose 5-phosphate (sodium) is a pentose phosphate ester and an essential intermediate metabolite in the pentose phosphate pathway (PPP) and the non-oxidative phase of the pentose phosphate pathway D-xylulose-5-phosphate can be efficiently synthesized through the phosphorylation of D-xylulose catalyzed by D-xylulokinase (XKS1 from Saccharomyces cerevisiae) with ATP regeneration facilitated by the phosphoenolpyruvate (PEP)/pyruvate kinase (PK) system[1]
Medchemexpress LLC Cyclic GMP-AMP (disodium); 3',3'-cGAMP (disodium) | 2407516-83-8 | 98.47% | 718.37 | 1 MG
cGAMP disodium is an endogenous second messenger that triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), leading to a signaling cascade that produces type I interferons and other immune mediators. This product is suitable for various research applications.
- Promotes antigen-specific proliferation capacity of spleen cells
- Directly activates murine and human dendritic cells in vitro
- Increases transcription of IFNB1 in stimulated fibroblasts
- Induces an antiviral state and type I IFN secretion by activating ER-resident receptor STING
Apexbio Technology LLC Pamidronate Disodium 57248-88-1 50mg
Pamidronate Disodium (CAS 57248-88-1) is a small-molecule inhibitor targeting osteoclastic bone resorption It is designed to inhibit osteoclast-mediated bone degradation thereby regulating bone metabolism Pamidronate Disodium exerts its biological activity primarily through selective binding to hydroxyapatite crystals in bone followed by suppression of osteoclast activity and induction of osteoclast apoptosis In in vitro studies Pamidronate Disodium demonstrates inhibitory activity on osteoclastic bone resorption with an IC50 in the micromolar range (varying according to experimental conditions) Based on these pharmacological properties Pamidronate Disodium holds research potential in studies of bone density disorders osteoporosis hypercalcemia of malignancy and metastatic bone diseases
Apexbio Technology LLC Clodronate Disodium 22560-50-5 50mg
Clodronate Disodium is a synthetic bisphosphonate designed to inhibit osteoclast-mediated bone resorption thereby interfering with bone remodeling processes Clodronate Disodium exerts its biological activity primarily by inducing apoptosis of osteoclasts and hindering their formation and function Liposome-encapsulated Clodronate Disodium formulations are also used experimentally to selectively deplete macrophages in vivo Based on these pharmacological properties Clodronate Disodium holds research potential in studies of osteoclast biology bone metabolic pathways osteoporosis metastatic bone disease arthritis and in investigating macrophage-mediated inflammatory and autoimmune responses as well as tumor-associated macrophage functions
Medchemexpress LLC Mevalonate 5-phosphate trilithium | 868553-49-5 | 99.0% | 245.94 | 1 MG
Mevalonate 5-phosphate trilithium is a substrate of phosphomevalonate kinase and mevalonate-5-phosphate decarboxylase. It is for research use only and not sold to patients.
Medchemexpress LLC Lobenzarit disodium | 64808-48-6 | MFCD00941422 | 99.9% | 335.65 | C14H8ClNNa2O4 | 25 MG
Lobenzarit disodium is the disodium salt form of lobenzarit, supplied as a high-purity solid research reagent (CAS 64808-48-6) described as an anti-arthritic and anti-oxidative agent. It is intended for laboratory research use and is offered in small pack sizes suitable for preclinical and in vitro studies.
- High purity (≈99.9%) suitable for research applications.
- Solid form for easy weighing and handling.
- Supplied as the disodium salt for use in research studies.
- Available in multiple small pack sizes (5-500 mg) for preclinical work.
- Used as an anti-arthritic and anti-oxidative research compound.
Medchemexpress LLC Piperaquine (phosphate) | 85547-56-4 | 98.6% | 25 MG
Piperaquine phosphate is a bisquinoline antimalarial agent. It can be used in antimalarial research in combination with Artemisinin.
- Bisquinoline antimalarial agent.
- Can be used in antimalarial research in combination with Artemisinin.
- In vivo, Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia in mice.
- At a dose of 90 mg/kg, it resulted in stable body weights and active mice throughout the study.
- Purity: 98.62%.
Medchemexpress LLC NSC-87877 (disodium) | 56932-43-5 | 98.0% | 503.42 | C19H11N3Na2O7S2 | 10 MG
NSC-87877 disodium is the disodium salt form of a small-molecule inhibitor of protein tyrosine phosphatases SHP-1 and SHP-2, intended for research use in biochemical and cell-based studies. It is provided as a solid and characterized for biochemical potency and composition.
- Potent inhibitor of SHP-1 and SHP-2 (IC50 ≈ 0.318 μM and 0.355 μM).
- Provided as the disodium salt for improved solubility and handling.
- High purity (98.0%) suitable for research applications.
- Molecular weight 503.42 and formula C19H11N3Na2O7S2 for precise mass calculations.
- Available in small milligram pack sizes for screening and assay development.
Apexbio Technology LLC Phosphatase Inhibitor Cocktail (1 Tube, EDTA-Free, 100X)(Synonyms: Phosphatase Inhibitor Cocktail, Phosphatase Inhibitor Mix, Phosphatase Inhibitor Set), 50X1ml.
Phosphatase Inhibitor Cocktail (1 Tube EDTA-Free 100X) provides comprehensive inhibition of various phosphatases including acid and alkaline phosphatases serine/threonine phosphatases (e g PP1 PP2A PP2B) and protein tyrosine phosphatases (PTPs) By suppressing phosphatase enzymatic activities it preserves phosphorylation states of proteins in lysates from mammalian plant yeast insect or bacterial samples ensuring more accurate downstream analysis It is applicable in protein lysate preparations immunoprecipitations nuclear extracts and processing of fixed tissues (e g FFPE) to maintain phosphorylation modifications
Medchemexpress LLC Lometrexol disodium | 120408-07-3 | 98.0% | C21H23N5Na2O6 | 1 MG
Lometrexol disodium is an antipurine antifolate that inhibits glycinamide ribonucleotide formyltransferase (GARFT) and human Serine hydroxymethyltransferase1/2 (hSHMT1/2). This leads to the inhibition of de novo purine synthesis, causing abnormal cell proliferation, apoptosis, and cell cycle arrest, thus exhibiting anticancer activity.
- Inhibits purine synthesis.
- Induces cell apoptosis.
- Causes cell cycle arrest.
- Demonstrates anticancer properties.