Sphingolipids
Medchemexpress LLC N-heptadecanoyl-d-erythro-sphingosylphosphorylcholine | 121999-64-2 | 99.7% | 717.05 g/mol | C40H81N2O6P | 5 MG
C17 sphingomyelin (d18:1/17:0) is a synthetic sphingomyelin analog used as an internal standard for quantitative lipid analysis, particularly mass spectrometry-based sphingomyelin quantification. It is provided as a high-purity analytical-grade solid suitable for LC-MS workflows.
- High purity (99.67%) for reliable quantitation.
- Molecular formula C40H81N2O6P; molecular weight 717.05 g/mol.
- Suitable as an internal standard for LC-MS quantitation of sphingomyelin.
- Available in small pack sizes for analytical use.
Medchemexpress LLC N-Hexanoylsphingosine | 124753-97-5 | 99.8% | 397.63 | 100 MG
C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator exhibiting significant anticancer activity. It plays a role in mediating miR-29b expression, which is involved in suppressing the progression of multiple myeloma by targeting the Akt signal pathway. This compound demonstrates a range of anti-cancer properties and can enhance the effects of chemotherapy in drug-resistant cancer cells.
- Short-chain, cell-permeable ceramide pathway activator
- Possesses anticancer activity
- Mediates miR-29b expression
- Suppresses proliferation, migration, and angiogenesis of endothelial cells
- Targets the Akt signal pathway
- Induces cell cycle arrest and apoptosis
- Inhibits tumor growth
- Enhances chemotherapy effects in drug-resistant cancer cells
- Useful as an adjuvant for chemotherapeutic agents
Medchemexpress LLC C6-NBD Sphinganine | 114301-97-2 | 99.0% | C30H51N5O6 | 1 MG
C6-NBD Sphinganine is a sphinganine analog utilized as a fluorescent dye for labeling fatty acids. This compound is intended for research use only and is not sold to patients. It has a molecular weight of 577.76 and appears as a yellow to orange solid. It exhibits an emission at 538 nm and an excitation at 460 nm.
- Functions as a fluorescent dye for labeling fatty acids, with specific excitation and emission wavelengths.
- Presents as a solid with a yellow to orange color.
- Soluble in DMSO at 20 mg/mL (34.62 mM); requires ultrasonic and warming for dissolution.
- Store at -20°C sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month.
- Strictly for research purposes; not for human use.
Cayman Chemical C12 NBD dihydro Ceramide d18
A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Medchemexpress LLC C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) | 74713-59-0 | 98.0% | 425.69 | 50 MG
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. It possesses anti-proliferation properties and acts as a potent chemotherapeutic agent. It stimulates dendritic cells to promote T cell responses upon virus infections and induces slight activation of protein kinase (PKC) in vitro.
- Acts as a potent chemotherapeutic agent.
- Possesses anti-proliferation properties.
- Stimulates dendritic cells to promote T cell responses.
- Induces slight activation of protein kinase (PKC) in vitro.
- Irreversibly reduces tumor-cell proliferation.
- Can induce necrosis-like cell death.
- May increase endogenous ROS levels, causing anti-proliferation and triggering apoptosis.
- Increases CD8+ T cell response to influenza in mice.
Medchemexpress LLC N-Octanoyl-D-erythro-sphingosine | 74713-59-0 | 98.0% | 425.69 | 100 MG
N-Octanoyl-D-erythro-sphingosine | 74713-59-0 | 98.0% | 425.69 | 100 MG
Medchemexpress LLC C18:1-Ceramide | 5966-28-9 | 99.9% | C36H69NO3 | 1 ML
C18:1-Ceramide is a ceramide subspecies that can be used in the study of type 2 diabetes.
- Ceramide subspecies
- Endogenous metabolite
- Related to metabolic disease and glucose metabolism research
- Classified as an alkaloid
Medchemexpress LLC C16 PEG2000 Ceramide | 212116-78-4 | 99.37% | (C2H4O)nC39H73NO6 | 25 MG
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide that functions as a lipid carrier for delivery and induces autophagy. This compound is also utilized in cancer research, exhibiting cytotoxicity and promoting autophagy in N2a cells in vitro.
- Functions as a lipid carrier for delivery
- Induces autophagy
- Used in cancer research
- Exhibits cytotoxicity in N2a cells
- Promotes autophagy in N2a cells
- Increases LC3-II/LC3-I ratios in N2a cells
- Reduces WT-Tau and P301L-Tau proteins in N2a cells
Medchemexpress LLC Sphingomyelin Syntha 50ug
The sphingomyelin synthase 2 (SGMS2) protein plays a crucial role in plasma membrane sphingomyelin synthesis It catalyzes the reversible transfer of the phosphocholine moiety in sphingomyelin biosynthesis to form ceramide phosphocholine Sphingomyelin Synthase 2/SGMS2 Protein Human (HEK293 Fc) is the recombinant human-derived Sphingomyelin Synthase 2/SGMS2 protein expressed by HEK293 with N-mFc labeled tag
Cayman Chemical ω-azido-C6 Ceramide, Purity: ≥95%, CAS: 2108102-18-5, 10 mg
A clickable form of C6 ceramide; active against N. meningitidis and N. gonorrhoeae (MIC = 2 µg/ml for both); has been used to conjugate alkynylated fluorescent probes to liposomes containing ω-azido-C6 ceramide via a click reaction
Medchemexpress LLC Sphingomyelin | 85187-10-6 | ≥99.0% | 100 MG
Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann-Pick disease.
- In vitro: Sphingomyelin metabolism results in the production of various interconvertible bioactive sphingolipids or derivatives such as ceramide, diacylglyceride, and sphingosine-1-phosphate. These bioactive lipids act on their specific targets within the cell and regulate various signal transduction pathways, thereby affecting cellular functions. Sphingomyelin enriched lipid raft mediated cell signaling.
Medchemexpress LLC C26 Sphingomyelin (d18:1/26:0)-d4 | 98.0% | 847.32 | 1 MG
C26 Sphingomyelin (d18:1/26:0)-d4 is a deuterium-labeled sphingomyelin for research use. It is intended for laboratory chemicals and substance manufacturing.
- For research use only
- Stable as a solid for up to 3 years at -20°C
- Stable as a solid for up to 2 years at 4°C
- Stable in solvent for up to 6 months at -80°C
- Stable in solvent for up to 1 month at -20°C
- Appears as a white to off-white solid
Apexbio Technology LLC Ceramide(Synonyms: N-Acylsphingosine, Ceramides, Acylsphingosine, sphingosine N-acyl derivative, N-Acyl-D-sphingosine), 5mg, CAS: 3102-57-6.
Ceramide (CAS 3102-57-6) is a bioactive lipid molecule known to modulate diverse cellular processes including proliferation and differentiation It exerts its effects primarily by activating several serine/threonine protein phosphatases notably protein phosphatase-1 (PP1) protein phosphatase-2A (PP2A) and ceramide-activated protein phosphatase (CAPP) in vitro Due to its regulatory role in fundamental signaling pathways ceramide serves as a valuable research tool in investigations addressing cell cycle progression apoptosis and cellular homeostasis
Apexbio Technology LLC Ceramide(Synonyms: N-Acylsphingosine, Ceramides, Acylsphingosine, sphingosine N-acyl derivative, N-Acyl-D-sphingosine), 25mg, CAS: 3102-57-6.
Ceramide (CAS 3102-57-6) is a bioactive lipid molecule known to modulate diverse cellular processes including proliferation and differentiation It exerts its effects primarily by activating several serine/threonine protein phosphatases notably protein phosphatase-1 (PP1) protein phosphatase-2A (PP2A) and ceramide-activated protein phosphatase (CAPP) in vitro Due to its regulatory role in fundamental signaling pathways ceramide serves as a valuable research tool in investigations addressing cell cycle progression apoptosis and cellular homeostasis
Medchemexpress LLC C8 PEG750 Ceramide | 212116-76-2 | 99.94% | 1 MG
C8 PEG750 Ceramide is a lipid product designed to synthesize a lipid bilayer carrier. It enables the selective delivery of various diagnostic and therapeutic agents to acidic diseased cells.
- Synthesizes a lipid bilayer carrier
- Facilitates selective delivery of diagnostic and therapeutic agents
- Targets acidic diseased cells