Steroids and derivatives
Medchemexpress LLC 21-deoxycortisone | 1882-82-2 | MFCD00051123 | >95.0% | 344.44 | C21H28O4 | 10mg
21-Deoxy Cortisone (21-Desoxycortisone NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone It is formed from 11-ketoprogesterone by the cytochrome P450 (CYP) isozyme CYP17A1 but can also be produced by oxidation of 21-deoxycortisone (HY-113405) by 11 -hydroxysteroid dehydrogenase type 2 (11 -HSD2) Congenital adrenal hyperplasia is an inborn error of metabolism characterized by a deficiency of 21-hydroxylase and 21-Deoxy Cortisone levels are elevated in patients with congenital adrenal hyperplasia
Medchemexpress LLC Dexamethasone (Standard) | 50-02-2 | MFCD00064136 | 99.0% | 392.46 | 100 MG
Dexamethasone (Standard) | 50-02-2 | MFCD00064136 | 99.0% | 392.46 | 100 MG
Cayman Chemical Dexamethasone Phosphate sodi
A glucocorticoid; reduces LPS-induced production of RANTES, TGF-β1, and NO in BV-2 microglia from 1-4 µM; reverses LPS-induced decreases in IL-10 levels in, and inhibits LPS-induced migration of, BV-2 microglia at 4 µM; decreases motor activity and reduces adrenal weight and plasma corticosterone levels in rats when administered in the drinking water at 5 UG/ml; reduces joint swelling in a rat model of collagen-induced arthritis at 1.6 mg/kg per day for a minimum of seven days; reduces pruritis and the clinical lesion score in cats with hypersensitivity dermatitis
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | 486.64 | 5 MG
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is intended for research use only.
- Down-regulates GR transcript in hCMEC/D3 cells in a dose-dependent manner.
- Supplementation leads to a significant increase in TER across the hCMEC/D3 monolayer.
- Treated dendritic cells (DCs) exhibit decreased expression of MHC II molecules, costimulatory molecule CD86, and DC-specific marker CD83.
- Treated dendritic cells (DCs) show strongly reduced IL-12 secretion.
- Treated dendritic cells (DCs) inhibit IFN-γ production but induce increased release of IL-4.
- Reduces post-ischemic oxidative stress, perfusion pressure, and transudate formation.
- Inhibits post-ischemic shedding of syndecan-1, heparan sulfate, and hyaluronan.
- Inhibits histamine release from mast cells.
Sigma Aldrich Fine Chemicals Biosciences Estriol 16alpha beta D glu10MG
Estriol 16alpha beta D glu10MG
TARGETMOL CHEMICALS INC DEXAMETHASONE SODIUM PHO 100MG
Also available in 10 mg 25 mg 50 mg 200 mg 500 mg 1000 mg and bulk. Please contact Fisher for quotes. Dexamethasone Sodium Phosphate (Dexadreson) an interleukin receptor modulator has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid synthetic drugs. purity: 99%
Medchemexpress LLC Dexamethasone (Water Soluble) | 50-02-2 | MFCD00064136 | 98.9% | 1493.5 g/mol | 500 MG
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone and acts as a glucocorticoid receptor agonist and apoptosis inducer. It is used in experimental animals to construct models of muscle atrophy, hypertension, and depression. This compound can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes, with potential for COVID-19 research.
- Regulates transcription factors like activator protein-1, nuclear factor-AT, and nuclear factor-kB.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells.
- Used in animal modeling for muscle atrophy, hypertension, and depression.
Medchemexpress LLC Dexamethasone phosphate disodium | 2392-39-4 | 99.94% | 516.40 | 500 MG
Dexamethasone phosphate disodium is an orally active Glucocorticoid receptor agonist. It regulates various transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, to influence inflammatory response genes.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells
- Induces transcription of the β2-receptor
- Inhibits 3xκB (NF-κB, IκBα, and I-κBβ) activity
- Efficiently inhibits lipopolysaccharide (LPS)-induced inflammation in vivo
- Decreases recruitment of granulocytes and spontaneous production of oxygen radicals in vivo
Medchemexpress LLC Cortisone acetate (Standard) | 50-04-4 | 99.4% | 402.48 | 50 MG
Cortisone acetate (Standard) serves as an analytical standard for research and analytical applications. This compound, an oxidized metabolite of Cortisol, functions as an immunosuppressant and anti-inflammatory agent. It is commonly utilized in qualitative, quantitative, and methodological research experiments across various techniques.
- Analytical standard for research
- Reference standard for assays
- Immunosuppressant properties
- Anti-inflammatory agent
- Used in HPLC, GC, and MS experiments
Sigma Aldrich Fine Chemicals Biosciences Prednisolone >=99% | 50-24-8 | MFCD00003649 | 10G
Prednisolone >=99% | Purity: >=99% | Mol Wt: 360.44 | 50-24-8 | MFCD00003649 | 10G
Sigma Aldrich Fine Chemicals Biosciences Cortisone >=98% | 53-06-5 | MFCD00003610 | 5G
Cortisone >=98% | Purity: >=98% | Mol Wt: 360.44 | 53-06-5 | MFCD00003610 | 5G
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 1 ML
Glycocholic acid is a bile acid with anticancer activity, targeting both pump resistance-related and non-pump resistance-related pathways. It increases the cytotoxicity of epirubicin and significantly increases its intracellular accumulation and absorption.
- Intensifies epirubicin-induced apoptosis.
- Reduces mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2.
- Downregulates the MDR1 promoter region.
- Suppresses the mRNA expression of Bcl-2 and induces the mRNA expression of Bax.
- Increases the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9, and -3.
- Can control multidrug resistance (MDR) by modulating P-gp and MRPs, and regulating apoptosis-related pathways when combined with anticancer drugs.
Cambridge Isotope Laboratories ( )-trans-3-Hydroxycotinine (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
( )-trans-3-Hydroxycotinine (unlabeled) 100 ug/mL in acetonitrile 1 2 mL