Steroids and derivatives
Medchemexpress LLC 17β-estradiol sulfate sodium | 4999-79-5 | MFCD00056553 | 99.0% | 374.43 g·mol⁻¹ | C18H23NaO5S | 5 MG
17β-estradiol sulfate sodium is the sodium salt of the sulfate metabolite of 17β-estradiol supplied as a solid research reagent. It is used for studies of estrogen metabolism, receptor binding, and neuroactive steroid activity. For research use only; not for human or veterinary use.
- Sodium salt of 17β-estradiol sulfate.
- High purity (99.0%).
- Molecular weight 374.43 g·mol⁻¹.
- Chemical formula C18H23NaO5S.
- Provided as a white to light yellow solid.
- SDS and COA available for quality and safety documentation.
Medchemexpress LLC Estradiol-d2-1 | 3188-46-3 | 5 MG
Estradiol-d2-1 is a deuterium-labeled form of Estradiol, a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway and is intended for research use only. Deuteration can impact pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, or LC-MS techniques.
- Deuterium-labeled form of estradiol.
- Upregulates IL-6 expression through the ERβ pathway.
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | MFCD00003693 | 99.98% | 100 MG
Estradiol (Standard) is the analytical standard of Estradiol, a steroid hormone and the major female sex hormone. This compound can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. It is used in research for cancers, neurodegenerative diseases, and neural tissue engineering.
- Used as a reference standard for assays
- Utilized in qualitative, quantitative, and methodological research experiments
- Promotes neural differentiation of human endometrial stem cells
- Supports research in cancers, neurodegenerative diseases, and neural tissue engineering
- Commonly used in HPLC, GC, and MS applications
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate | 172377-52-5 | MFCD00947822 | 351.46 | 100 MG
Estradiol 3-sulfamate, also known as E2MATE, is a potent, long-acting, and orally active steroid sulfatase inhibitor. It effectively inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. This compound is transformed and absorbed in the gut into its oxidative metabolite, EMATE, both of which are strong steroid sulfatase inhibitors. It is intended for research use only.
- Potent, long-acting steroid sulfatase inhibitor
- Orally active
- Inhibits estrone sulfatase (IC50 of 251 nM)
- Shows growth inhibitory effects on various cancer cell lines
Apexbio Technology LLC α-Estradiol 57-91-0 50mg
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
eMolecules 79037-37-9 | Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | MFCD01074033 | 275.406 | C18H24O2
Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | 79037-37-9 | MFCD01074033 | 275.406 | C18H24O2
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 10mM (in 1mL DMSO)
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Medchemexpress LLC Alpha-Estradiol | 57-91-0 | 99.9% | 5 G
Alpha-Estradiol is identified as a weak estrogen and a 5α-reductase inhibitor. It is employed as a topical medication for treating androgenic alopecia.
- Weak estrogen.
- Acts as a 5α-reductase inhibitor, preventing testosterone metabolism catalyzed by 5 alpha-reductase.
- Attenuates LPS-induced inflammatory markers in mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes, and differentiated 3T3-L1 adipocytes through an ERα-dependent mechanism.
- Decreases NFκB-p65 and elevates ERα protein expression.
- Significantly reduces the central avascular/total retina area in mouse pups.
- Lowers malondialdehyde (MDA) levels, the number of NADPH-oxidase-positive cells, NADPH oxidase concentration, and activity in the retinas of hyperoxia-exposed pups.
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 5 MG
Beta-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol. It is provided as a white to off-white solid.
- Consistent with structure by 1H NMR and LCMS.
- High purity of 98.83% (LCMS).
- Store at 4°C under nitrogen for solid form.
- In solvent, store at -80°C for up to 6 months or -20°C for 1 month, both under nitrogen.
Medchemexpress LLC Alpha-Estradiol | 57-91-0 | MFCD00064144 | 99.9% | 500 MG
Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
- Acts as a weak estrogen
- Functions as a 5α-reductase inhibitor
- Suitable for topical medication in the treatment of androgenic alopecia
- Purity of 99.88%
- Inhibits testosterone metabolism
- Attenuates LPS-induced inflammatory markers
- Decreases malondialdehyde (MDA) levels
Medchemexpress LLC 17β-Estradiol sulfate-d4 sodium | 352431-50-6 | 99.57% | C18H19D4NaO5S | 1 MG
17β-Estradiol sulfate-d4 sodium is the deuterium labeled form of 17β-Estradiol sulfate. This compound, also known as β-Estradiol 3-sulfate sodium salt, functions as a neuroactive steroid, making it relevant for research in neuroscience and steroid biology.
- Deuterium labeled compound for specialized research
- Functions as a neuroactive steroid
- Also known as β-Estradiol 3-sulfate sodium salt
Medchemexpress LLC β-Estradiol 17-hemisuccinate | 7698-93-3 | 98.8% | 372.45 | 25 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol. It is designed for research use and is stored at 4°C under nitrogen. When in solvent, it is recommended to store it at -80°C for up to 6 months or -20°C for up to 1 month, also under nitrogen.
- Synthetic derivative of estradiol
- Stored at 4°C under nitrogen
- In solvent, stable for 6 months at -80°C
- In solvent, stable for 1 month at -20°C
Santa Cruz Biotechnology β-Estradiol 3-sulfate sodium salt, 25 mg | CAS# 4999-79-5
β-Estradiol 3-sulfate sodium salt functions as a steroid hormone and exhibits estrogenic activity. It acts by binding to estrogen receptors, estrogen receptor alpha and beta, within the cell nucleus. This binding initiates a cascade of molecular events, leading to the regulation of gene expression and the modulation of various cellular processes. β-Estradiol 3-sulfate sodium salt′s mechanism of action involves influencing the transcription of target genes, thereby impacting the physiological responses of the cells. By interacting with estrogen receptors, β-Estradiol 3-sulfate sodium salt plays a role in the regulation of cell proliferation, differentiation, and apoptosis. Its activity at the molecular level contributes to the modulation of various signaling pathways and cellular functions, making it a relevant component in studies exploring hormone signaling and related biological processes.
