Steroids and derivatives
Cambridge Isotope Laboratories 2 6-Dinitrotoluene (methyl-D3 98%) 1 mg/mL in acetonitrile 1 mL
2 6-Dinitrotoluene (methyl-D3 98%) 1 mg/mL in acetonitrile 1 mL
MOLECULAR DEPOT LLC 25-OH Vitamin D3 Biotin - 1 mg
25-OH Vitamin D3 Biotin Conjugate consists of 25-OH Vitamin D3 conjugated to Biotin via a 22 A spacer arm The spacer adds flexibility to the 25-OH Vitamin D3 moiety which is required for its interaction with specific antibodies and other binding partners This compound has been tested for use in several 25-OH Vitamin D applications including ELISA The conjugate is supplied as a DMSO stock solution For in vitro research use only
Medchemexpress LLC Fluorometholone acetate | 3801-06-7 | 98.5% | 50MG
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has an anti-inflammatory effect and has the potential for external ocular inflammation research.
- Synthetic glucocorticoid corticosteroid
- Potent carbonic anhydrase inhibitor
- Exhibits anti-inflammatory effects
- Potential for external ocular inflammation research
Medchemexpress LLC (Z)-Guggulsterone | 39025-23-5 | 99.4% | 312.45 | 100 MG
(Z)-Guggulsterone, a constituent of the Indian Ayurvedic medicinal plant *Commiphora mukul*, has been shown to inhibit the growth of human prostate cancer cells by inducing apoptosis. It also inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling pathway. Additionally, (Z)-Guggulsterone acts as a potent FXR antagonist and has been observed to reduce ACE2 expression and SARS-CoV-2 infection.
- Inhibits growth of human prostate cancer cells by inducing apoptosis.
- Inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling pathway.
- Acts as a potent FXR antagonist.
- Reduces ACE2 expression and SARS-CoV-2 infection.
- Decreases level of VEGF-R2 protein in HUVEC.
- Reduces ACE2 and SHP levels in primary airway and intestinal organoids.
Sigma Aldrich Fine Chemicals Biosciences Escin United States Pharmacopeia (USP) Reference Standard | 11072-93-8 | 350MG
Escin United States Pharmacopeia (USP) Reference Standard | 11072-93-8 | 350MG
Medchemexpress LLC Estrone sulfate (potassium) | 1240-04-6 | 99.9% | 388.52 | 1 ML
Estrone sulfate potassium is an inactive endogenous estrogen that can be converted into Estrone and Estradiol. It is also a substrate of the OATP1B3 transporter. This compound is applicable to breast cancer-related research, as it stimulates the growth of nitrosomethylurea-induced mammary tumors and promotes colony formation of dispersed nitrosomethylurea mammary cells through its conversion to Estrone and Estradiol.
- Taken up at a low rate by normal breast parenchymal cells.
- Converted to estrone by normal breast parenchymal cells.
- Stimulates colony formation in dispersed nitrosomethylurea mammary cells.
- Exerts dose-related stimulatory effects on nitrosomethylurea-induced hormone-responsive mammary tumor growth in castrate rats.
- Reduces glucose-6-phosphatase activity and protein levels, and lowers blood glucose in ob/ob mice.
- Modulates glucose-6-phosphatase kinetic parameters in control mice.
Medchemexpress LLC Estrone 3-glucuronide sodium | 15087-01-1 | HY-W008917 | 98.8% | 468.47 | 5 MG
Estrone 3-glucuronide sodium is a metabolite of 17-Estradiol. It is used as a standard to estimate estrone conjugate (E1Cs) from urine samples by enzyme immunoassays (EIAs) and as a reference standard in assays that measure urinary E1C, a key marker for tracking the transition to the luteal phase.
- Used as a standard to estimate estrone conjugate (E1Cs) from urine samples by enzyme immunoassays (EIAs).
- Reference standard in assays that measure urinary E1C.
- Key marker for tracking the transition to the luteal phase.
Medchemexpress LLC Estrone O-sulfamate | 148672-09-7 | 100.0% | C18H23NO4S | 10MG
Estrone O-sulfamate is a research-grade steroid sulfatase inhibitor supplied as a high-purity solid for biochemical and pharmacological studies. It is intended for use in assays of steroid metabolism and enzyme inhibition, with recommended refrigerated storage and solvent stability guidelines for long-term experiments.
- Potent steroid sulfatase (STS) inhibitor suitable for in vitro studies.
- High purity solid for reliable analytical and biological assays.
- White to off-white powder, convenient for weighing and formulation.
- Stable under recommended storage conditions and protected from light.
- Available in small research pack sizes to minimize waste and enable pilot studies.
Medchemexpress LLC Estrone | 53-16-7 | 99.96% | 1 ML
Estrone (E1) is a natural estrogenic hormone and the main representative of endogenous estrogens. It is produced by several tissues, particularly adipose tissue, through the aromatization of androstenedione in fat cells.
- Purity of 99.96%
- Molecular weight of 270.37
- Chemical formula C18H22O2
- Appears as a solid, white to off-white
- Initial source from microorganisms or as an endogenous metabolite
- Available as a 10 mM, 1 mL solution in DMSO
- Soluble in DMSO (25 mg/mL or 92.47 mM)
- Insoluble in water
- For research use only
Cayman Chemical Estrone Steroid Hormones
A primary, naturally-occurring estrogen; serum concentrations in premenopausal women fluctuate according to the menstrual cycle; becomes the most predominant estrogen in postmenopausal women; binding affinities to ERα and ERβ are ~60% and ~37% relative to estradiol