Purine nucleosides
Cambridge Isotope Laboratories 8-Hydroxy-2-deoxyguanosine (15N5 98%) CP 95% 1 mg
8-Hydroxy-2-deoxyguanosine (15N5 98%) CP 95% 1 mg
Medchemexpress LLC 2'-Deoxyguanosine 5'-monophosphate disodium hydrate | 146877-98-7 | 99.0% | C10H14N5O7.H2O.2Na | 100 MG
2'-Deoxyguanosine 5'-monophosphate disodium hydrate (dGMP) is an oxidizable target of the photosensitizer pterin. It can be used to evaluate the photosensitizing properties of biopterins. Pterin causes a photosensitive reaction of dGMP under UV-A radiation, leading to DNA damage. This process involves two main mechanisms in vitro for the photosensitive oxidation of purine nucleotides by pterin.
- A hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism).
- Interaction between dGMP and pterin produces singlet molecular oxygen (1O2) (type II mechanism).
Sigma Aldrich Fine Chemicals Biosciences 5-Deoxyadenosine methylthi25MG
5-Deoxyadenosine methylthi25MG
Medchemexpress LLC Malvidin-3-O-arabinoside chloride | 28500-04-1 | 97.10% | 498.86 | 1 MG
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. It upregulates LAMP-1 expression, restores lysosomal acidity, strengthens lysosomal functions, and stimulates phosphorylation of AMP-activated protein kinase (AMPK).
- Upregulates LAMP-1 expression
- Restores lysosomal acidity
- Strengthens lysosomal functions
- Stimulates phosphorylation of AMP-activated protein kinase (AMPK)
- Inhibits excess ROS generation
- Enhances GSH level
- Enhances autophagy flux
- Up-regulates the LC3-II/LC3-I ratio
Medchemexpress LLC 2'-Deoxyguanosine monohydrate | 312693-72-4 | 99.7% | 10 G
2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and 2'-deoxyribose, and it is one of the basic structural units of DNA. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which in turn may affect gene expression or induce cancer.
- Composed of guanine and 2'-deoxyribose.
- Basic structural unit of DNA.
- Oxidation products may participate in DNA damage.
- Can affect gene expression or induce cancer.
- High purity of 99.70%.
- Ships at room temperature.
- Store solid at 4°C, sealed, away from moisture.
- Store in solvent at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture.
Medchemexpress LLC 2'-Deoxyguanosine-13C10,15N5 monohydrate | 2483830-26-6 | 99.8% | 1 MG
2'-Deoxyguanosine-13C10,15N5 (monohydrate) is the 13C and 15N labeled 2'-Deoxyguanosine monohydrate, which is an endogenous metabolite. It is for research use only and not sold to patients.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation during the drug development process.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Chem-Impex International, Inc. 2'-Deoxyadenosine monohydrate | 16373-93-6 | MFCD00149364 | 1G
2'-Deoxyadenosine monohydrate, 16373-93-6, MFCD00149364, 1G
Genscript Corporation CA15-3 AntibodyA5D8 mAb Mo
CA15-3 (Carcinoma antigen 15-3) is also known as MUC 1 antigen It is a membrane-anchored mucin-type glycoprotein present in malignant cells It is used as tumor marker to monitor breast cancer treatment and disease recurrence
Cambridge Isotope Laboratories 2-Deoxyguanosine 5-triphosphate ammonium salt (15N5 98-99%) CP 90% (in solution) 20 umol
2-Deoxyguanosine 5-triphosphate ammonium salt (15N5 98-99%) CP 90% (in solution) 20 umol
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 25 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. This product is for research use only and not for sale to patients.
- Treatment results in rapid cell death for the vast majority of cancer cell lines tested, with IC50s between 0.7-2.9 μM.
- In A549 lung cancer cell-based mouse xenograft studies, it causes a decrease of the tumor growth rate, superior to that observed with 6-thioguanine treatment.
- It increases telomere dysfunction in tumor cells in vivo.
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | 99.9% | 267.25 | 10 G
2'-Deoxyguanosine is a purine nucleoside with diverse biological activities, known to induce DNA division in mouse thymus cells and act as a potent cell division inhibitor in plant cells. It also demonstrates inhibitory effects on the clonal growth of HL-60 and K562 leukemia cells, with observed IC50 values of 50 and 80 μM, respectively. This compound typically appears as a solid, ranging from white to off-white in color.
- Endogenous metabolite
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Apexbio Technology LLC 6-O-Propynyl-2-deoxyguanosine 25mg
6-O-Propynyl-2-deoxyguanosine (CAS 1640051-47-3) is a modified nucleoside featuring an alkyne functional group at the 6-position of deoxyguanosine This structural modification enables its use in bioorthogonal click chemistry reactions facilitating site-specific labeling and conjugation in nucleic acid research The alkynyl group serves as a chemical handle for copper-catalyzed azide-alkyne cycloaddition allowing researchers to attach probes or other functional molecules 6-O-Propynyl-2-deoxyguanosine is utilized for studying DNA structure dynamics and for the development of modified oligonucleotides in biochemical and molecular biology assays
Medchemexpress LLC 2'-Deoxyadenosine-5'-triphosphate-d14 (dilithium) (dATP-d14 (dilithium)) | 2687960-68-3 | 97.10% | 517.13 | 1 MG
2'-Deoxyadenosine-5'-triphosphate-d14 (dATP-d14) dilithium is deuterium labeled 2'-Deoxyadenosine-5'-triphosphate. It is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. This product is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.