Purine nucleosides
Medchemexpress LLC 2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 1 MG
2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 1 MG
Apexbio Technology LLC 6-O-Propynyl-2-deoxyguanosine 1mg
6-O-Propynyl-2-deoxyguanosine (CAS 1640051-47-3) is a modified nucleoside featuring an alkyne functional group at the 6-position of deoxyguanosine This structural modification enables its use in bioorthogonal click chemistry reactions facilitating site-specific labeling and conjugation in nucleic acid research The alkynyl group serves as a chemical handle for copper-catalyzed azide-alkyne cycloaddition allowing researchers to attach probes or other functional molecules 6-O-Propynyl-2-deoxyguanosine is utilized for studying DNA structure dynamics and for the development of modified oligonucleotides in biochemical and molecular biology assays
Medchemexpress LLC Malvidin-3-O-arabinoside chloride | 28500-04-1 | 97.10% | 498.86 | 1 MG
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. It upregulates LAMP-1 expression, restores lysosomal acidity, strengthens lysosomal functions, and stimulates phosphorylation of AMP-activated protein kinase (AMPK).
- Upregulates LAMP-1 expression
- Restores lysosomal acidity
- Strengthens lysosomal functions
- Stimulates phosphorylation of AMP-activated protein kinase (AMPK)
- Inhibits excess ROS generation
- Enhances GSH level
- Enhances autophagy flux
- Up-regulates the LC3-II/LC3-I ratio
Medchemexpress LLC 8-Bromo-2'-deoxyadenosine | 14985-44-5 | ≥98.0% | 330.14 | 50 MG
8-Bromo-2'-deoxyadenosine is a purine nucleoside analog. These analogs possess broad antitumor activity, specifically targeting indolent lymphoid malignancies. Their anticancer mechanisms involve inhibiting DNA synthesis and inducing apoptosis.
- Purine nucleoside analog
- Has broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
Cayman Chemical N6-Methyl-2-deoxyadenosIn 25mg
A nucleoside and inducer of EPC proliferation; stimulates the proliferation of EPCs isolated from mouse fetal livers and colony formation of isolated mouse bone marrow cell-derived progenitor cells at 10 and 100 µM; accumulates along promoters and gene coding sequences in activated mouse prefrontal cortical neurons; is associated with activation at the Bdnf promoter
Medchemexpress LLC 6-Thio-2'-deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 10 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. This compound has shown rapid cell death in various cancer cell lines with IC50 values between 0.7-2.9 μM. In A549 lung cancer cell-based mouse xenograft studies, it decreased tumor growth rate, outperforming 6-thioguanine treatment, and increased telomere dysfunction in tumor cells in vivo. It is for research use only.
- Nucleoside analogue
- Incorporated into de novo-synthesized telomeres by telomerase
- Induces rapid cell death in various cancer cell lines
- Decreases tumor growth rate in mouse xenograft studies
- Increases telomere dysfunction in tumor cells in vivo
Medchemexpress LLC Adenosine, 5'-deoxy- | 4754-39-6 | 99.9% | 251.246 | 50 MG
5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects. It shows anti-orthopoxvirus activity.
- Oxidized nucleoside
- Found in the urine of normal subjects
- Shows anti-orthopoxvirus activity
Cayman Chemical 2-Fluoro-2-deoxyadenosIn 5g
A prodrug form of 2-F-adenine; reduces mean tumor weight in an E. coli purine nucleoside phosphorylase-expressing D54 glioblastoma mouse xenograft model at 100 mg/kg
Medchemexpress LLC N6-cyclopentyladenosine | 41552-82-3 | MFCD00036845 | 100.0% | 335.36 g/mol | C15H21N5O4 | 1 ML
N6-Cyclopentyladenosine is a selective adenosine A1 receptor agonist used as a research reagent in pharmacology and receptor signaling studies. Supplied as a 10 mM solution in a 1 mL vial, it is intended for in vitro experiments and receptor-binding assays.
- Selective adenosine A1 receptor agonist for pharmacological studies.
- Provided as a 10 mM solution for ready-to-use experiments.
- High chemical purity suitable for research applications.
- Compact 1 mL vial format for small-scale assays.
- Molecular weight 335.36 g/mol; molecular formula C15H21N5O4.
Innovative Research Inc Imprtn A2 RcmbPrtn N6 Htag
Human Importin alpha 2 Recombinant Protein N-6 His Tag 50UG - Human Importin alpha 2 Recombinant Protein N-6 His Tag is produced in E. coli. This is a Liquid protein buffered in a 0.2 um filtered solution of 20mM TrisHCl,1mM DTT,20% Glycerol, pH 8.0 . It is not recommended to reconstitute to a concentration less than 100UG/ml. with a purity of greater than 95% per reducing SDS-PAGE.Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.Karyopherin Subunit alpha-2 (KPNA2) belongs to the importin alpha family. KPNA2 is widely expressed in many tissues and contains an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminal. KPNA2 interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.KPNA2 functions in nuclear protein importantly as an adapter protein for nuclear receptor KPNB1 For RUO.
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | 99.21% | 267.24 | 100 MG
2'-Deoxyguanosine (Standard) is an analytical standard of 2'-Deoxyguanosine, intended for research and analytical applications. It is a purine nucleoside with various biological activities, including inducing DNA division in mouse thymus cells and acting as a potent cell division inhibitor in plant cells. It also inhibits the clonal growth of HL-60 and K562 leukemia cells with IC50 values of 50 and 80 μM, respectively.
- Analytical standard for 2'-Deoxyguanosine.
- Intended for research and analytical applications.
- Purine nucleoside with various biological activities.
- Induces DNA division in mouse thymus cells.
- Potent cell division inhibitor in plant cells.
- Inhibits clonal growth of HL-60 and K562 leukemia cells (IC50 values of 50 and 80 μM).
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Meridian Life Science HUMAN CANCER ANTIGEN CA15-3
Cancer Antigen CA15-3 (Breast Cancer) Antigen Grade
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | 99.9% | 267.25 | 10 G
2'-Deoxyguanosine is a purine nucleoside with diverse biological activities, known to induce DNA division in mouse thymus cells and act as a potent cell division inhibitor in plant cells. It also demonstrates inhibitory effects on the clonal growth of HL-60 and K562 leukemia cells, with observed IC50 values of 50 and 80 μM, respectively. This compound typically appears as a solid, ranging from white to off-white in color.
- Endogenous metabolite
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation