Drug Standards
Apexbio Technology LLC Methylprednisolone(Synonyms: Medrol, Depo-Medrol, Solu-Medrol, Advantan, Urbason, Metipred, Medrate, Metilprednisolone), 100mg, CAS: 83-43-2.
Methylprednisolone (CAS 83-43-2) is a synthetic glucocorticoid receptor agonist that exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines notably TNF- and modulating NF- B signaling pathways In vitro studies demonstrate that methylprednisolone reduces TNF production and enhances IL-10 synthesis in mouse macrophages upon LPS stimulation suppresses chemokine secretion from human peripheral blood mononuclear cells and inhibits acantholysis in skin cultures Animal models indicate that intravenous methylprednisolone administration attenuates inflammation decreases macrophage infiltration and tissue damage post-spinal cord injury Clinically methylprednisolone is investigated for therapeutic use in acute spinal cord injury severe vasculitis and lupus nephritis
Selleck Chemical LLC Gallamine Triethiodide 50mg 65-29-2
Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ¿ 8.4 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Cabazitaxel 183133-96-2 5mg
Cabazitaxel (CAS 183133-96-2) is a semisynthetic compound derived from the natural precursor 10-deacetylbaccatin III belonging to the taxoid class of antineoplastic agents It exerts its biological effects primarily by stabilizing microtubules thus disrupting mitotic and interphase cellular functions and causing cell-cycle arrest leading to apoptosis Due to this microtubule-targeting activity cabazitaxel is extensively studied in oncology research particularly investigating chemoresistant tumor cell lines and therapeutic approaches for taxane-resistant cancers
Medchemexpress LLC 5H-1-Benzazepin-5-one, 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro- | 137977-97-0 | 99.9% | 328.80 | 500 MG
Tolvaptan Impurity from MedChemExpress is a chemical compound with the molecular formula C18H17ClN2O2 and a molecular weight of 328.80. It is provided as a white to off-white solid with a purity of 99.92%. This product is intended for research use only and has not been fully validated for medical applications.
- Provided as a white to off-white solid
- Purity of 99.92%
- Suitable for research applications
- Store as powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Selleck Chemical LLC Cefditoren Pivoxil 10mg 117467-28-4 ME-1207
Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | 42017-89-0 | MFCD00792461 | 25MG
Fenofibrate Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 318.75 | 42017-89-0 | MFCD00792461 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Voriconazole United States Pharmacopeia (USP) Reference Standard | 137234-62-9 | MFCD00905717 | 100MG
Voriconazole United States Pharmacopeia (USP) Reference Standard | Mol Wt: 349.31 | 137234-62-9 | MFCD00905717 | 100MG
Apexbio Technology LLC Fostamatinib (R788) 901119-35-5 10mg
Fostamatinib (R788 CAS 901119-35-5) is an orally available small-molecule inhibitor targeting spleen tyrosine kinase (Syk) with an IC50 of approximately 41 nM As a prodrug fostamatinib is rapidly converted to its active metabolite R406 an ATP-competitive inhibitor of Syk (Ki 30 nM) R406 additionally inhibits related kinases such as Flt3 Lyn (IC50 63 nM) and Lck (IC50 37 nM) thereby modulating BCR- and Fc receptor-mediated signaling pathways Preclinical studies demonstrate activity of fostamatinib in various autoimmune and inflammatory models including SLE-related nephritis and dermatitis in MRL/lpr mice highlighting its utility as a research tool in autoimmune disease investigation
Medchemexpress LLC Impurity C of calcitriol | 86307-44-0 | MFCD22124487 | 99.8% | C35H49N3O5 | 10MG
Impurity C of calcitriol (CAS 86307-44-0) is a characterized impurity of calcitriol used as an analytical reference standard in research and method development. Supplied as a high-purity solid, it is intended for chromatographic and spectroscopic applications; users should consult the lot-specific certificate of analysis for exact specifications.
- High purity suitable for analytical standards and reference use.
- Provided as a solid for convenient handling and storage.
- Compatible with chromatographic and spectroscopic methods.
- Useful for impurity profiling and method validation.
- Batch-specific certificate of analysis available for exact specifications.
Medchemexpress LLC Ganoderic acid A | 81907-62-2 | 516.67 | 1 ML
Ganoderic acid A can inhibit the JAK-STAT3 signaling pathway, and also inhibit proliferation, viability, and ROS. This compound is intended for research use only and not for sale to patients.
- Inhibits JAK-STAT3 signaling pathway
- Inhibits proliferation, viability, and ROS
- Cytotoxic against Bel-7402 cells with an IC50 of 7.25 μM
- Cytotoxic against HepG2 cells with a CC50 of 80 μM and IC50 of 38.7 μM
- Enhances HLA class II-mediated antigen presentation
- Promotes cisplatin-induced cell death via STAT3 suppression
- Inhibits proliferation and induces apoptosis in human osteosarcoma HOS and MG-63 cells
- High purity of 99.26%
- Soluble in DMSO and ethanol
- Shipped at room temperature
- Storage at 4°C (solid) and -80°C/-20°C (in solvent)
Medchemexpress LLC Fexofenadine (hydrochloride) | 153439-40-8 | 99.9% | 50 MG
Fexofenadine hydrochloride is an orally active and nonsedative H1 receptor antagonist. It can be used in allergic rhinitis and chronic idiopathic urticarial research. In vitro studies show that Fexofenadine inhibits IL-6 protein expression and blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts. In vivo, it suppresses eosinophilia and systemic anaphylaxis in T. spiralis-infected mice.
- Orally active H1 receptor antagonist
- Nonsedative properties
- Inhibits IL-6 protein expression in nasal fibroblasts
- Blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts
- Suppresses eosinophilia and systemic anaphylaxis in relevant animal models
Apexbio Technology LLC (S)-Flurbiprofen 51543-39-6 500mg
(S)-Flurbiprofen (CAS 51543-39-6) is the pharmacologically active enantiomer of the 2-aryl propionic acid class of non-steroidal anti-inflammatory drugs (NSAIDs) It acts as a dual inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with an IC50 of approximately 0 5 M against both isoforms in guinea pig whole blood assays In preclinical models topical administration of (S)-Flurbiprofen demonstrated significant analgesic and anti-inflammatory effects reducing inflammatory pain and edema in rat arthritis experiments Clinical studies have also supported its analgesic efficacy and safety in the management of osteoarthritis This compound is widely used in research focused on inflammation pain modulation and cyclooxygenase inhibition
Medchemexpress LLC Tivantinib (ARQ 197) | 905854-02-6 | 99.6% | 369.42 | 5 MG
Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM. It is a low-molecular-weight compound and the first orally available selective inhibitor of c-Met. Tivantinib selectively inhibits c-Met activity in cell-free and cell-based assays, causing dose-dependent loss of proliferative capacity or caspase-dependent apoptosis in c-Met-expressing cancer cell lines.
- Highly selective c-Met tyrosine kinase inhibitor
- Ki of 355 nM
- Selectively inhibits c-Met activity in cell-free and cell-based assays
- First orally available selective inhibitor of c-Met
- Inhibits constitutive c-Met phosphorylation in HT29 and MKN-45 cells, and HGF-induced c-Met phosphorylation in MDA-MB-231 and NCI-H441 cells with an IC50 of 100 to 300 nM
- Strongly inhibits c-Met phosphorylation in human colon xenograft tumors (HT29)
Medchemexpress LLC Isradipine | 75695-93-1 | 99.9% | 1 ML
Isradipine is an orally active and blood-brain barrier permeable L-type calcium channel blocker. It acts as a powerful peripheral vasodilator and is a dihydropyridine calcium antagonist with selective actions on both the heart and peripheral circulation. It is considered a potentially viable neuroprotective agent for Parkinson's disease.
- Orally active and blood-brain barrier permeable
- L-type calcium channel blocker
- Powerful peripheral vasodilator
- Dihydropyridine calcium antagonist
- Selective actions on heart and peripheral circulation
- Potentially neuroprotective agent for Parkinson's disease
- Targets calcium channel and autophagy
- Used in cardiovascular and neurological disease research
Sigma Aldrich Fine Chemicals Biosciences Allyl cyclohexane valerate United States Pharmacopeia (USP) Reference Standard | 7493-68-7 | 3X0.5ML
Allyl cyclohexane valerate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 224.34 | 7493-68-7 | 3X0.5ML