Drug Standards
Apexbio Technology LLC Econazole nitrate 24169-02-6 1g
Econazole nitrate (24169-02-6) is a small-molecule inhibitor targeting the enzyme 14 -demethylase It is designed to disrupt ergosterol synthesis in fungal membrane sterol biosynthesis thereby decreasing membrane integrity altering permeability and attenuating fungal cellular growth Econazole nitrate exerts its biological activity primarily through inhibition of 14 -demethylase In vitro studies demonstrate antifungal activity with reported IC50 values against various fungal isolates typically ranging from approximately 0 05 to 1 g/mL depending on experimental parameters and organism specificity Based on these pharmacological properties econazole nitrate holds research potential in antifungal susceptibility testing exploration of drug resistance mechanisms in fungal strains characterization of dermatopathogenic microorganisms and drug target identification studies
Selleck Chemical LLC Anidulafungin (LY303366) 10mg 166663-25-8
Anidulafungin (LY303366), an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Fluconazole hydrate 155347-36-7 10mM (in 1mL DMSO)
Fluconazole hydrate (CAS 155347-36-7) is a small-molecule inhibitor targeting the fungal enzyme lanosterol 14 -demethylase It is designed to inhibit ergosterol biosynthesis thereby disrupting fungal cell membrane integrity and arresting fungal growth Fluconazole hydrate exerts its biological activity primarily through inhibition of lanosterol 14 -demethylase In in vitro studies fluconazole hydrate demonstrates inhibitory activity with documented IC50 values typically ranging from 0 1 to 10 g/mL depending on fungal strain and experimental conditions Based on these pharmacological properties fluconazole hydrate holds research potential in antifungal pharmacology assays fungal infection model studies and evaluation of combinational antifungal therapies
Medchemexpress LLC Ketoconazole | 65277-42-1 | 99.57% | C26H28Cl2N4O4 | 1 ML
Ketoconazole | 65277-42-1 | 99.57% | C26H28Cl2N4O4 | 1 ML
Apexbio Technology LLC Betahistine 2HCl 5579-84-0 10g
Betahistine 2HCl (CAS 5579-84-0) is a small-molecule inhibitor targeting histamine H3 receptors exhibiting an inhibitory concentration (IC50) of 1 9 M By antagonizing H3 receptors betahistine modulates histaminergic neurotransmission which influences the release of various neurotransmitters in the central nervous system This compound is widely utilized in research focused on the physiological roles of histamine signaling particularly in studies of neurological and vestibular disorders as well as in the exploration of H3 receptor pharmacology and modulation
Apexbio Technology LLC Ritodrine HCl 23239-51-2 10mM (in 1mL DMSO)
Ritodrine hydrochloride (CAS 23239-51-2) is a selective 2-adrenergic receptor agonist that modulates smooth muscle activity By stimulating 2-adrenergic receptors ritodrine promotes uterine muscle relaxation thereby inhibiting premature uterine contractions Comparative studies indicate that ritodrine can rapidly extend the interval before delivery although it is associated with a higher incidence of adverse effects compared to alternatives such as magnesium sulfate Ritodrine HCl is widely used in research to investigate 2-adrenergic signaling pathways and to model the pharmacological regulation of preterm labor
Medchemexpress LLC 1'-epi Gemcitabine hydrochloride | 122111-05-1 | C9H12ClF2N3O4 | 1 MG
1'-epi Gemcitabine hydrochloride is an isomer of Gemcitabine hydrochloride. It functions as an experimental control. The parent compound, Gemcitabine Hydrochloride, is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. It works by inhibiting DNA synthesis and repair, leading to processes such as autophagy and apoptosis.
- Used as an experimental control
- Isomer of gemcitabine hydrochloride
- Parent compound inhibits DNA synthesis and repair
- Parent compound induces autophagy and apoptosis
Medchemexpress LLC Voriconazole-d3 | 1217661-14-7 | 99.9% | C16H11D3F3N5O | 1 MG
Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. It exerts its antifungal activity by inhibiting 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes.
- Can be used as a tracer.
- Can be utilized as an internal standard for quantitative analysis through methods such as NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, including deuterium, have been incorporated into drug molecules as tracers for quantitation during drug development.
- Deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
Apexbio Technology LLC Gonadorelin Acetate 71447-49-9 10mg
Gonadorelin Acetate is a synthetic peptide agonist targeting gonadotropin-releasing hormone (GnRH) receptors It is designed to bind specifically to GnRH receptors on pituitary gonadotrophs thereby modulating secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) Gonadorelin Acetate exerts its biological activity primarily through receptor-mediated regulation of the reproductive hormone axis Based on these pharmacological properties Gonadorelin Acetate holds research potential in studies of reproductive hormone signaling pathways endocrine regulation associated with infertility disorders and characterization of gonadotropin responses in cellular or animal models
Apexbio Technology LLC Moxifloxacin HCl 186826-86-8 50mg
Moxifloxacin HCl (186826-86-8) is a small-molecule inhibitor targeting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV It is designed to inhibit these enzymes thereby disrupting essential bacterial DNA replication transcription and repair processes Moxifloxacin HCl exerts its biological activity primarily through inhibition of DNA gyrase and topoisomerase IV It demonstrates antibacterial activity against both Gram-positive and Gram-negative bacteria including ciprofloxacin-resistant strains with MIC90 values for ciprofloxacin-susceptible strains up to 0 6 g/mL Additionally moxifloxacin inhibits human serum paraoxonase-1 (hPON1) with a Ki value of 2 641 0 004 mM Based on these pharmacological properties Moxifloxacin HCl holds research potential in studying antibacterial mechanisms and enzyme-inhibitor interactions
Apexbio Technology LLC Acebutolol HCl 34381-68-5 10mM (in 1mL DMSO)
Acebutolol hydrochloride (CAS 34381-68-5) is a selective 1-adrenergic receptor antagonist By competitively inhibiting the binding of catecholamines to 1-adrenergic receptors acebutolol modulates sympathetic nervous system activity resulting in decreased heart rate and myocardial contractility This pharmacological profile underlies its utility in preclinical studies on cardiovascular regulation including models of hypertension angina pectoris and cardiac arrhythmias Acebutolol HCl is widely used in biomedical research to investigate -adrenergic signaling pathways and to evaluate therapeutic approaches targeting cardiac function and blood pressure control
Apexbio Technology LLC Citalopram hydrobromide 59729-32-7 10mM (in 1mL DMSO)
Citalopram hydrobromide (CAS 59729-32-7) is a selective serotonin reuptake inhibitor (SSRI) that functions by specifically blocking the reuptake of 5-hydroxytryptamine (5-HT) at presynaptic neuronal membranes thereby increasing 5-HT concentrations in the synaptic cleft In vitro studies demonstrate that citalopram hydrobromide exhibits potent nanomolar-level inhibition of 5-HT reuptake in synaptosomal preparations as well as low nanomolar inhibition in rabbit platelet assays This compound is widely utilized in research exploring serotonergic signaling neurotransmission processes and experimental models of depression
Apexbio Technology LLC Naphazoline HCl 550-99-2 5g
Naphazoline HCl (CAS 550-99-2) is a synthetic imidazoline derivative that acts as a sympathomimetic amine It primarily targets -adrenergic receptors on vascular smooth muscle inducing vasoconstriction through the activation of these receptors This property leads to reduced blood flow and decreased vascular congestion particularly in ocular tissues Naphazoline HCl is frequently employed in research to investigate adrenergic signaling pathways and to model vasoconstrictive mechanisms in vitro and in vivo Its pharmacological profile makes it a valuable tool for studies involving vascular responses and ocular pharmacodynamics