Drug Standards
Apexbio Technology LLC Oprozomib (ONX-0912) 935888-69-0 25mg
Oprozomib (ONX-0912 CAS 935888-69-0) is an orally bioavailable small-molecule inhibitor of the proteasome structurally related to carfilzomib It targets predominantly the chymotrypsin-like proteolytic activity of the proteasome inducing apoptosis and growth inhibition in multiple myeloma (MM) cell lines including those resistant to bortezomib In preclinical models oprozomib activates pro-apoptotic pathways involving caspases-3 -8 -9 as well as PARP cleavage suppresses angiogenesis and tumor cell migration thereby reducing tumor progression and prolonging survival Its biological activity positions oprozomib as a promising compound for MM research
Apexbio Technology LLC Acarbose 56180-94-0 2g
Acarbose (CAS 56180-94-0) is a small-molecule inhibitor targeting intestinal -glucosidase an enzyme involved in carbohydrate digestion It exerts its pharmacological action by hindering the hydrolytic breakdown of complex carbohydrates into monosaccharides thereby slowing glucose absorption Demonstrating potent inhibitory activity with an IC of approximately 11 nM acarbose is widely explored in biomedical research contexts related to glucose regulation and diabetes management
Medchemexpress LLC Diphenhydramine hydrochloride | 147-24-0 | 99.93%
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist exhibiting anti-cholinergic effects. This compound is capable of crossing the ovine blood-brain barrier.
- Inhibits cisplatin-induced cell death in kidney proximal tubular cells.
- Inhibits cell viability in CCRF-CEM and Jurkat cells.
- Induces apoptosis in CCRF-CEM and Jurkat cells.
- Increases expression of Bad and Bax, and decreases BCL-2 level in PANC-1 cells.
- Decreases expression of various phosphorylated proteins (p-AKT, p-mTOR, p-FoxO1, p-MDM2, p-NF-ĸB p65, and p-GSK-3) in PANC-1 cells.
- Inhibits cisplatin-induced kidney toxicity in mice.
- Reduces mortality in rats with acute, severe dichlorvos exposure.
Medchemexpress LLC CPD-10 | 3055471-57-0 | 96.7% | 888.07 | 1 MG
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. It shows anti-proliferation and induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, and P-Rb(5807/811) in a dose-dependent manner.
- Potent CCND1 and CDK4 PROTAC degrader
- Shows anti-proliferation
- Induces apoptosis
- Decreases protein expression of cyclin D1, cyclin D3, CDK4, P-Rb(5807/811) in a dose-dependent manner
Medchemexpress LLC Benzeneacetamide, 4-butoxy-N-hydroxy- | 2438-72-4 | 98.0% | 500 MG
Bufexamac is a selective IIb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, demonstrating Kds of 0.53 μM for HDAC6 and 0.22 μM for HDAC10. It also functions as a nonsteroidal anti-inflammatory drug, useful in various research applications.
- Selective dual inhibitor of HDAC6, HDAC10, and LTA4H.
- Functions as a nonsteroidal anti-inflammatory drug.
- Inhibits IFN-α secretion in peripheral blood mononuclear cells.
- Inhibits HDAC10 to block autophagic flux, enhancing tumor-specific toxicity of DNA damage-inducing drugs.
- Inhibits neutrophil chemotaxis via inhibition of LTA4H-mediated endogenous LTB4 biosynthesis.
- Ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.
Selleck Chemical LLC SRT1720 HCl 50mg 1001645-58-4
SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 ?M in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Diaveridine | 5355-16-8 | MFCD00057349 | 99.8% | 5 G
Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. It is intended for research use only.
- Dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM
- Functions as an antibacterial agent
- Exhibits strong bactericidal effect on S. typhimurium TA1535 at 10 μg/mL or more
- Causes a dose-dependent, significant increase in aberrant metaphases at 100 μg/mL
- Does not cause abnormal chromosome aberration at studied doses
- Does not produce significant changes in organ-to-body weight ratio
Sigma Aldrich Fine Chemicals Biosciences Diphenhydramine N-oxide United States Pharmacopeia (USP) Reference Standard | 13168-00-8 | 25MG
Diphenhydramine N-oxide United States Pharmacopeia (USP) Reference Standard | Mol Wt: 307.82 | 13168-00-8 | 25MG
Medchemexpress LLC Olaparib impurity 22 | 420846-72-6 | MFCD20483902 | 250mg
Olaparib impurity 22 is an impurity of Olaparib (HY-10162)
Medchemexpress LLC Dabigatran impurity 52 | 1416446-45-1 | 25mg
Dabigatran impurity 52 is an impurity of Dabigatran (HY-10163)
Apexbio Technology LLC Gabapentin HCl 60142-95-2 100mg
Gabapentin HCl (CAS 60142-95-2) is a structurally related analog of gamma-aminobutyric acid (GABA) though it does not bind directly to GABA receptors Its primary mechanism involves binding to the 2 subunit of voltage-gated calcium channels in neuronal tissues resulting in decreased neurotransmitter release Originally investigated for antiepileptic properties gabapentin has been widely utilized in research exploring neuropathic pain modulation and neuronal excitability This molecule serves as a tool compound for studying calcium channel modulation and the pathophysiology of neurological disorders
Sigma Aldrich Fine Chemicals Biosciences Moxifloxacin Related Compound G United States Pharmacopeia (USP) Reference Standard | 1394029-14-1 | 15MG
Moxifloxacin Related Compound G United States Pharmacopeia (USP) Reference Standard | Mol Wt: 437.89 | 1394029-14-1 | 15MG
Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.2% | 10 MG
Osimertinib dimesylate is an irreversible, mutant-selective epidermal growth factor receptor (EGFR) inhibitor supplied as a solid research standard for in vitro and analytical applications. It demonstrates potent activity against activating and resistance EGFR mutants, with reported IC50 values of 12 nM (EGFR L858R) and 1 nM (EGFR L858R/T790M).
- Irreversible, mutant-selective EGFR inhibitor for research and analytical use.
- Demonstrated potency: IC50 12 nM (EGFR L858R) and 1 nM (EGFR L858R/T790M).
- High purity (99.19%) suitable for biochemical assays and analytical standards.
- Solid powder form, available in small mass sizes such as 10 mg.
- Chemical formula C30H41N7O8S2; molecular weight 691.82 g/mol.
- Storage: store sealed away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
Apexbio Technology LLC Enoxaparin 50mg
Enoxaparin (CAS 679809-58-6) is a low molecular weight heparin derivative that acts by potentiating the inhibitory activity of antithrombin III leading to the inhibition of coagulation factors such as thrombin (factor IIa) Through this mechanism Enoxaparin demonstrates anticoagulant properties Experimental studies indicate that it confers neuroprotection in rat hippocampus following traumatic brain injury via antioxidative and anti-inflammatory pathways Enoxaparin is widely used in research investigating deep vein thrombosis pulmonary embolism traumatic brain injury and thrombotic complications associated with COVID-19
Selleck Chemical LLC Dexamethasone Acetate 10mM/1mL 1177-87-3 NSC 39471
Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. *For Research & Development use only. Product is not intended for drug, household, or human consumption.