Drug Standards
Apexbio Technology LLC Glipizide 29094-61-9 10mM (in 1mL DMSO)
Glipizide (CAS 29094-61-9) is a small molecule that acts by inhibiting ATP-sensitive potassium channels in pancreatic cells leading to membrane depolarization and subsequent stimulation of insulin secretion Additionally it modulates ATP-dependent K channels in GABAergic neurons within the brain Glipizide is widely used in research to investigate pancreatic cell physiology insulin release mechanisms and the role of KATP channels in neuroendocrine regulation
Selleck Chemical LLC Onalespib (AT13387) S1163-5mg
Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells displays a long duration of anti-tumor activity Phase 2
Apexbio Technology LLC Elacridar(Synonyms: GF120918, GG918, GW0918, GF-120918, GG-918, GW-0918), 100mg, CAS: 143664-11-3.
Elacridar (CAS 143664-11-3) is a potent inhibitor of P-glycoprotein (P-gp) a transmembrane efflux transporter belonging to the MDR/TAP subfamily P-gp actively exports diverse xenobiotics and drugs from cells significantly influencing drug bioavailability and distribution Elacridar inhibits P-gp with an IC50 of approximately 193 nM and markedly reduces transporter activity in P-gp-overexpressing MDCKII cell models at concentrations as low as 1 M In mice elacridar administration (10 mg/kg) enhances brain penetration of P-gp substrates such as sunitinib Thus elacridar is extensively used in biomedical research to study drug transport mechanisms and multidrug resistance
Medchemexpress LLC (±)-Nornicotine | 5746-86-1 | 148.20 | 50 MG
(±)-Nornicotine is a major metabolite of Nicotine that acts as a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. This compound disrupts β-catenin and ZO-1, and induces F-actin depolymerization. It supports self-administration behavior and can be utilized in research concerning atherosclerosis, Alzheimer's disease, and schizophrenia.
- Acts as a partial nAChRs agonist
- Activates receptor subtypes containing α7 and α6 subunits
- Disrupts β-catenin and ZO-1
- Induces F-actin depolymerization
- Supports self-administration behavior
- Suitable for research concerning atherosclerosis, Alzheimer's disease, and schizophrenia
- Promotes cell migration and disrupts adherens/tight junctions in vitro
- Maintains self-administration behavior in vivo
Sigma Aldrich Fine Chemicals Biosciences Imiquimod Related Compound A United States Pharmacopeia (USP) Reference Standard | 99010-24-9 | 25MG
Imiquimod Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 225.29 | 99010-24-9 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Phentolamine mesilate British Pharmacopoeia (BP) Reference Standard | 65-28-1 | MFCD00134201 |
Phentolamine mesilate British Pharmacopoeia (BP) Reference Standard | Mol Wt: 377.46 | 65-28-1 | MFCD00134201 |
Medchemexpress LLC Amoxicillin (sodium) | 34642-77-8 | 98.0% | 5 G
Amoxicillin (sodium) is an antibiotic with good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth. This product is intended for research use only.
- Inhibits biosynthesis of polypeptides in the cell wall
- Decreases living cells and increases cell wall rupture in L. acidophilus (in vitro)
- Inhibits bacterial numbers in mice (in vivo)
- Improves activity against Chlamydia trachomatis infection (in vivo)
- Supporting documentation available, including data sheets, COA, and SDS
Sigma Aldrich Fine Chemicals Biosciences Chlorobenzhydryl Piperazine United States Pharmacopeia (USP) Reference Standard | 300543-56-0 | 75MG
Chlorobenzhydryl Piperazine United States Pharmacopeia (USP) Reference Standard | Mol Wt: 286.8 | 300543-56-0 | 75MG
Apexbio Technology LLC Ciprofloxacin (hydrochloride)(Synonyms: Cipro, Ciprofloxacin HCl, Ciprofloxacine hydrochloride, Ciprofloxacin hydrochloride monohydrate), 25g, CAS: 93107-08-5.
Ciprofloxacin (hydrochloride) (CAS 93107-08-5) is a fluoroquinolone antibiotic targeting bacterial DNA gyrase and topoisomerase IV enzymes essential for bacterial DNA replication and supercoiling By inhibiting these enzymes ciprofloxacin prevents bacterial chromosome replication and proliferation It also displays immunomodulatory activity evidenced by reduced serum pro-inflammatory cytokines (IL-6 KC) and decreased apoptosis and autophagy in radiation-induced injury mouse models Ciprofloxacin is FDA-approved for treating inhalational anthrax exposure significantly enhancing survival in rhesus monkeys infected with aerosolized B anthracis
Medchemexpress LLC Tavarborol impurity 16 | 1839665-96-1 | MFCD32689443 | 247.06 | 5 G
Tavarborol impurity 16 is an impurity of Tavaborol. It is used as a drug intermediate.
- Impurity of Tavaborol
- Suitable for drug intermediate research
Selleck Chemical LLC Triamcinolone Acetonide S1628-1g
Triamcinolone acetonide is a synthetic glucocorticoid used in the symptomatic treatment of inflammation
Selleck Chemical LLC Betahistine 2HCl S3176-50mg
Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1 9 M
Selleck Chemical LLC Escitalopram Oxalate S4064-50mg
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0 89 nM
![Medchemexpress LLC 4H-imidazo[1,5-a]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo- | 84378-44-9 | 100.0% | 275.24 | C13H10FN3O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000229210.png-250.jpg)
Medchemexpress LLC 4H-imidazo[1,5-a]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo- | 84378-44-9 | 100.0% | 275.24 | C13H10FN3O3 | 1 ML
Flumazenil acid is the carboxylic acid metabolite of flumazenil, provided as a high-purity reference material for research on GABAA receptor pharmacology and drug metabolism. It is supplied as a powder and is commonly prepared as a 10 mM solution (1 mL) for in vitro studies.
- High purity: 99.96% as reported by certificate of analysis.
- Molecular formula C13H10FN3O3 and molecular weight 275.24 g/mol.
- Available as powder; solutions commonly prepared at 10 mM, 1 mL volumes.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Intended for research use in pharmacology and metabolism studies (in vitro).
Medchemexpress LLC Benzarone | 1477-19-6 | 99.7% | 266.29 | 500 MG
Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also functions as an uncoupler of oxidative phosphorylation. This compound has the potential to cause liver damage and can promote cell apoptosis and necrosis. It is utilized to reduce serum uric acid levels and for research related to vascular diseases.
- Oral inhibitor of human urate transporter 1 (hURAT1).
- Functions as an uncoupler of oxidative phosphorylation.
- Used to lower serum uric acid levels.
- Useful for research in vascular diseases.
- May cause liver damage and promote cell apoptosis and necrosis.