Acetylides
Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 5 G
Propargyl-PEG8-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also functions as a cleavable ADC linker for antibody-drug conjugates (ADCs), applicable in bacterial infections caused by Gram-negative bacteria. This product is also a click chemistry reagent, featuring an Alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.
- Click chemistry
- Alkyne applications
- ADC synthesis
- PROTAC synthesis
- Supports research in infection and cancer
- Used in cancer targeted therapy and immunotherapy
- Relevant for bacterial studies
eMolecules 4-Bromo-2-ethynylpyridine | 1196155-22-2 | 1G | Purity: 98%
Combi-Blocks | 4-Bromo-2-ethynylpyridine | 1G | 1196155-22-2 | MFCD13189721
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Medchemexpress LLC 4,7,10,13,16-pentaoxanonadec-18-ynoic acid | 1245823-51-1 | MFCD22201536 | ≥98.0% | 304.34 g/mol | C14H24O7 | 1 G
Propargyl-PEG5-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group and a free carboxylic acid. It is used as a click-chemistry reagent and as a non-cleavable five-unit PEG spacer for bioconjugation workflows such as PEGylation and antibody-drug conjugate linker synthesis. The material is supplied as a colorless to light-yellow liquid with ≥98.0% purity and is intended for research use; store protected from light at -20°C, or in solution at -80°C for longer-term storage.
- Contains terminal propargyl alkyne for copper-catalyzed azide-alkyne cycloaddition.
- Five-unit PEG spacer improves solubility and reduces aggregation.
- Free carboxylic acid enables conjugation through standard activation chemistries.
- High purity (≥98.0%) for reproducible research results.
- Colorless to light-yellow liquid; stable when stored protected from light at -20°C.
- Intended for research use only; not validated for clinical applications.
Medchemexpress LLC 3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol | 1422023-54-8 | ≥97.0% | 1 G
Propargyl-PEG7-alcohol is a versatile PEG linker with the chemical name 3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol. It has a molecular formula of C17H32O8 and a molecular weight of 364.43. This product is commonly utilized in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs).
- High purity of ≥97.0%
- Appears as a colorless to light yellow liquid
- Suitable for ADC and PROTAC development
- Stable storage conditions provided
eMolecules Ambeed / Methyl 2-ethynylbenzoate / 250mg / 552687157 / A272766 / / 33577-99-0 / MFCD12547057 / 160.172 / C10H8O2
Ambeed / Methyl 2-ethynylbenzoate / 250mg / 552687157 / A272766 / / 33577-99-0 / MFCD12547057 / 160.172 / C10H8O2
Medchemexpress LLC Propargyl-PEG1-acid | 55683-37-9 | 97.0% | 5 G
Propargyl-PEG1-acid is a PEG-based PROTAC linker, utilized in the synthesis of BTK-CRBN PROTACs, including Ibrutinib-based PROTAC 4 and PROTAC 5. PROTAC 5 is known to degrade BTK and induce degradation of CSK, LYN, and LAT2. This compound also functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. BTK-CRBN PROTACs are stoichiometric degraders, facilitating BTK protein degradation through the recruitment of cereblon E3 ligases.
- Peg-based PROTAC linker
- Used in synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Features an alkyne group for CuAAc reactions
- Degrades BTK protein
- Induces degradation of CSK, LYN, and LAT2
Medchemexpress LLC Tert-butyl 3,6,9,12-tetraoxapentadec-14-ynoate | 888010-02-4 | MFCD28122944 | >95.0% | C15H26O6 | 10MG
Propargyl-PEG3-OCH2-Boc is a Boc-protected PEG3 linker with a terminal propargyl (alkyne) group, designed for use as a building block in click chemistry and linker synthesis. It enables selective conjugation and orthogonal deprotection steps in multi-step synthetic workflows.
- Provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition.
- Boc protecting group enables orthogonal deprotection in multi-step syntheses.
- PEG3 spacer imparts hydrophilicity and flexible linker length.
- Supplied in small pack sizes suitable for medicinal chemistry applications.
- Characterized by defined molecular weight and formula for reproducible reactions.
eMolecules 3-Butoxy-5-(trifluoromethoxy)phenylboronic acid | 1256345-96-6 | MFCD16036112 | 1g
Combi-Blocks | 3-Butoxy-5-(trifluoromethoxy)phenylboronic acid | 1g | 117524581 | BB-6361 | 97.000 | 1256345-96-6 | MFCD16036112 | 278.030 | C11H14BF3O4
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