Acetylides
![eMolecules 22287-32-7 | (Bicyclo[1.1.1]pent-1-yl)methanol | Combi-Blocks | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 1g | 388722074](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000170645.jpg-250.jpg)
eMolecules 22287-32-7 | (Bicyclo[1.1.1]pent-1-yl)methanol | Combi-Blocks | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 1g | 388722074
(Bicyclo[1.1.1]pent-1-yl)methanol | Combi-Blocks | 22287-32-7 | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 1g | 388722074
Medchemexpress LLC VQW-765 | 669770-29-0 | MFCD28502153 | 99.6% | 294.39 g/mol | C19H22N2O | 10 MG
VQW-765 is an orally active, selective partial agonist of the α7 nicotinic acetylcholine receptor (α7-nAChR) developed for preclinical research into anxiety and related CNS disorders. Supplied as a pre-weighed 10 mg research reagent, it is intended for use in in vitro and in vivo studies and is not for human consumption.
- Selective α7 nicotinic acetylcholine receptor partial agonist.
- Orally active compound suitable for in vivo dosing.
- High chemical purity (approximately 99.6%).
- Supplied as a pre-weighed 10 mg quantity for dosing convenience.
- Appropriate for both in vitro and in vivo pharmacology studies.
- Research use only; not for human or clinical use.
Medchemexpress LLC O-Propargyl-Puromycin | 1416561-90-4 | 98.4% | 495.53 | 50 MG
O-Propargyl-Puromycin is a potent protein synthesis inhibitor and an alkyne analog of puromycin. It functions as a click chemistry reagent, featuring an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Protein synthesis inhibition: It effectively inhibits protein synthesis in both reticulocyte lysates and cultured cells.
- Covalent conjugates: This compound forms covalent conjugates with nascent polypeptide chains.
- Rapid turnover: These conjugates are rapidly turned over by the proteasome.
- Visualization and capture: The covalent conjugates can be visualized or captured through copper(I)-catalyzed azide-alkyne cycloaddition.
- Imaging and affinity purification: It can be utilized to image and affinity-purify nascent proteins within cells and animals.
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 | C10H16O5 | 250 MG
Propargyl-PEG3-acid is a PEG-based bifunctional linker featuring a terminal propargyl (alkyne) group and a carboxylic acid; it is used as a non-cleavable three-unit PEG linker for antibody-drug conjugates and as a PEG linker for PROTACs, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
- Non-cleavable three-unit PEG linker suitable for ADC and PROTAC synthesis.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition for conjugation to azide-containing molecules.
- High purity appropriate for research-scale bioconjugation workflows.
- Available in multiple pack sizes to support small-scale and larger preparative work.
eMolecules 886500-85-2 | 4-Chloro-3-(trifluoromethoxy)phenol | Apollo Scientific | MFCD06660247 | 212.550 | C7H4ClF3O2 | 98.000 | Oc1ccc(Cl)c(OC(F)(F)F)c1 | 1g | 562453315
4-Chloro-3-(trifluoromethoxy)phenol | Apollo Scientific | 886500-85-2 | MFCD06660247 | 212.550 | C7H4ClF3O2 | 98.000 | Oc1ccc(Cl)c(OC(F)(F)F)c1 | 1g | 562453315
Medchemexpress LLC Propargyl-O-C1-amido-PEG4-C2-NHS ester | 2101206-92-0 | 95.0% | 458.46 g/mol | C20H30N2O10 | 10 MG
Propargyl-O-C1-amido-PEG4-C2-NHS ester is a propargyl-functionalized PEG4 spacer bearing an N-hydroxysuccinimide (NHS) ester. It is used as a bioconjugation reagent for click-chemistry and linker construction, and is reactive toward primary amines. Store cold and dry to preserve NHS ester reactivity.
- Propargyl (alkyne) functional group for click chemistry.
- NHS ester reactive toward primary amines for conjugation.
- Four-unit PEG spacer for increased solubility and spacing.
- Molecular weight 458.46 g/mol.
- Purity 95.0%.
- Recommended storage: pure form at -20°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Propargyl-PEG8-Boc | 2055014-96-3 | 1 G
Propargyl-PEG8-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. This compound is instrumental in developing PROTACs, which are designed to selectively degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an Alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Interacts with Azide groups
- Facilitates selective degradation of target proteins
eMolecules 21020-27-9 | 4-METHYL-2-PENTYNE | AstaTech | MFCD00041615 | 82.146 | C6H10 | 95.000 | CC#CC(C)C | 0.25g | 718058629
4-METHYL-2-PENTYNE | AstaTech | 21020-27-9 | MFCD00041615 | 82.146 | C6H10 | 95.000 | CC#CC(C)C | 0.25g | 718058629
eMolecules 927-74-2 | 3-Butyn-1-ol | Medchem Express | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 500mg | 797053353
3-Butyn-1-ol | Medchem Express | 927-74-2 | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 500mg | 797053353
Matrix Scientific 4-ETHYNYLBENZOIC ACID4-ETHYN-1
4-ethynylbenzoic Acid Mf C9h6o2 Mw 146.15 Cas 10602-00-3 Mdl MFCD00168819
eMolecules 156425-08-0 | 4-Chloro-5-(trifluoromethoxy)benzene-1,2-diamine | MFCD23703477 | 1g
Ambeed | 5-(((S)-1-((2S4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-33-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid | 50mg | 788438991 | A1595811 | 2172819-73-5 | 544.670 | C27H36N4O6S
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Medchemexpress LLC Propargyl-PEG4-CH2CO2-NHS | 2144777-76-2 | 343.33 | 250 MG
Propargyl-PEG4-CH2CO2-NHS is a PEG derivative containing both a propargyl group and an NHS group. It functions as an ADC linker, used in the synthesis of antibody-drug conjugates (ADCs). This compound is also a click chemistry reagent, possessing an alkyne group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- PEG derivative with propargyl and NHS groups
- Functions as an ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG6-alcohol | 944560-99-0 | 97.0% | 1 G
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Used in the synthesis of proteolysis targeting chimeras (PROTACs)
- Contains an alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Propargyl-peg2-oh | 7218-43-1 | 99.66% | 5 G
Propargyl-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of Thalidomide-O-PEG2-propargyl. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. It has a molecular weight of 144.17 and a formula of C7H12O3. It appears as a colorless to light yellow liquid with a density of 1.06 g/cm3 and a purity of 99.66%.
- Peg-based protac linker
- Utilized in the synthesis of thalidomide-o-peg2-propargyl
- Click chemistry reagent
- Contains an alkyne group for cuaac reactions
- Intended for research use only
- Soluble in ethanol (≥ 100 mg/ml)