Acetylides
Medchemexpress LLC Propargyl-PEG1-bromide | 18668-74-1 | MFCD00099299 | 98.0% | 163.01 | C5H7BrO | 1 G
Propargyl-PEG1-bromide is an alkyne-functionalized short polyethylene glycol (PEG) linker bearing a terminal bromide. It is used in bioconjugation and medicinal chemistry to introduce a clickable propargyl handle while providing a reactive leaving group for further substitution, enabling efficient incorporation of a short PEG spacer into synthetic linkers and small-molecule constructs.
- Provides an alkyne (propargyl) handle for click chemistry.
- Contains a terminal bromide for nucleophilic substitution reactions.
- Short PEG1 spacer improves solubility and minimizes steric hindrance.
- Molecular weight ~163.01 g/mol for predictable stoichiometry.
- Suitable for linker synthesis, bioconjugation, and small-molecule modification.
Medchemexpress LLC Propargyl-PEG1-NHS ester | 1174157-65-3 | 99.7% | 225.20 g/mol | C10H11NO5 | 250 MG
A non-cleavable one-unit polyethylene glycol (PEG) linker supplied as an NHS ester with a terminal propargyl (alkyne) group. Designed for click chemistry (CuAAC) and antibody-agent conjugation, it is provided as a colorless to light-yellow solid-liquid mixture with high purity and recommended cold storage.
- One-unit PEG linker for minimal spacer length.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- NHS ester allows efficient coupling to primary amines.
- High purity suitable for conjugation chemistry.
- Cold storage recommended for long-term stability.
Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 250 MG
Propargyl-PEG5-Br is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. This linker is ideal for researchers developing novel protein degradation therapeutics.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG1-acid | 55683-37-9 | 97.0% | 5 G
Propargyl-PEG1-acid is a PEG-based PROTAC linker, utilized in the synthesis of BTK-CRBN PROTACs, including Ibrutinib-based PROTAC 4 and PROTAC 5. PROTAC 5 is known to degrade BTK and induce degradation of CSK, LYN, and LAT2. This compound also functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. BTK-CRBN PROTACs are stoichiometric degraders, facilitating BTK protein degradation through the recruitment of cereblon E3 ligases.
- Peg-based PROTAC linker
- Used in synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Features an alkyne group for CuAAc reactions
- Degrades BTK protein
- Induces degradation of CSK, LYN, and LAT2
Medchemexpress LLC Propargyl-PEG4-CH2CH2-Boc | 1245823-50-0 | 360.44 g·mol⁻¹ | C18H32O7 | 100 MG
Propargyl-PEG4-CH2CH2-Boc is a PEG-based linker bearing a terminal propargyl (alkyne) group and a Boc-protected amine. It is used as a non-cleavable ADC linker, a PROTAC linker, and as a reagent for click chemistry (copper-catalyzed azide-alkyne cycloaddition).
- Contains a terminal alkyne suitable for copper-catalyzed azide-alkyne cycloaddition.
- Boc-protected amine enables orthogonal deprotection strategies.
- Applicable as a non-cleavable ADC linker or a PROTAC linker in conjugation workflows.
- Molecular weight 360.44 g·mol⁻¹; CAS 1245823-50-0.
- Store pure material at -20°C for long-term stability; in solvent store at -80°C for best stability.
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 250 MG
Propargyl-PEG8-NH2 is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal primary amine for conjugation. It is used in proteolysis targeting chimera (PROTAC) and antibody-drug conjugate (ADC) linker synthesis, and as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Contains a terminal propargyl alkyne group for copper-catalyzed azide-alkyne cycloaddition.
- Provides a terminal primary amine (NH2) for amide coupling or conjugation.
- High purity suitable for synthetic applications and linker assembly.
- Available in small-scale quantities suitable for research use.
- Stable when stored under recommended conditions to preserve reactivity.
Medchemexpress LLC Propargyl-PEG2-CH2COOH | 944561-46-0 | ≥95.0% | 202.20 | 250 MG
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Used in the synthesis of PROTACs.
- Contains an Alkyne group.
- Can undergo copper-catalyzed azide-alkyne cycloaddition with Azide groups.
Accela Chembio Inc MF: C7H5N | MW: 103.12 | >97% | Flash Point: 76 celsius | BP: 90¿C/30mmHg | Density: 1.0190.
MF: C7H5N | MW: 103.12 | >97% | Flash Point: 76 celsius | BP: 90¿C/30mmHg | Density: 1.0190.
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 100 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess Azide groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an alkyne group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules possessing azide groups
Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 1 G
Propargyl-PEG2-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Functions as a PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Acts as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
![Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1428629-71-3 | 97.0% | 313.30 g/mol | C14H19NO7 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203474.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1428629-71-3 | 97.0% | 313.30 g/mol | C14H19NO7 | 250 MG
Propargyl-PEG3-NHS ester is an amine-reactive N-hydroxysuccinimide (NHS) ester with a terminal propargyl alkyne and a three-unit PEG spacer. It is designed for bioconjugation and linker chemistry, enabling amide bond formation with primary amines and copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide partners.
- Amine-reactive NHS ester for stable amide bond formation.
- Terminal alkyne enables CuAAC click chemistry.
- Three-unit PEG spacer provides flexibility and solubility.
- Suitable for PROTAC and antibody-drug conjugate linker synthesis.
- High purity (97.0% by NMR) and molecular weight 313.30 g/mol.
Medchemexpress LLC 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid | 1347760-82-0 | MFCD22201521 | 99.1% | 216.23 g/mol | C10H16O5 | 1 G
Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid handle, used for click chemistry and conjugation in small-molecule and bioconjugate synthesis.
- Terminal alkyne functional group for copper-catalyzed azide-alkyne cycloaddition
- Carboxylic acid end group for amide coupling and further derivatization
- Three-unit PEG spacer imparts solubility and flexibility
- High reported purity suitable for synthetic applications
- Available in 1 g pack for small-scale synthesis
![Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204167.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG
Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker containing a propargyl (alkyne) group and a disulfide bond, terminating in a carboxylic acid. It is intended for click-chemistry-enabled bioconjugation and as a reducible linker in antibody-drug conjugate synthesis.
- Cleavable disulfide linkage for reductive release.
- Alkyne handle compatible with copper-catalyzed azide-alkyne cycloaddition.
- Carboxylic acid terminus for amide coupling or further functionalization.
- Purity typically ≥95%.
- Available in multiple sizes, including 100 mg.
- Stable when stored under recommended temperatures.
Medchemexpress LLC Propargyl-PEG5-NHS ester | 1393330-40-9 | 98.0% | 401.41 g/mol | C18H27NO9 | 250 MG
Propargyl-PEG5-NHS ester is an alkyne-terminated, amine-reactive PEG5 NHS ester used for bioconjugation and click chemistry. The NHS ester reacts with primary amines to form stable amide bonds, while the propargyl (alkyne) group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it suitable for linker incorporation in antibody-drug conjugates and PROTAC synthesis.
- Amine-reactive NHS ester for stable amide formation.
- Alkyne (propargyl) handle for copper-catalyzed click chemistry.
- PEG5 spacer provides hydrophilicity and conformational flexibility.
- High purity suitable for research-grade bioconjugation.
- Available in milligram to gram pack sizes for method development.
Medchemexpress LLC Boc-Propargylamine | 92136-39-5 | 99.5% | C8H13NO2 | 25 G
Boc-Propargylamine is a biochemical reagent suitable for use as a biological material or organic compound in life science research. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Used to prepare triazolobenzylidene-thiazolopyrimidines, which act as CDC25 phosphatase inhibitors.
- Used for the synthesis of beta-glucan polysaccharide analogs.
- Involved in the Pauson-Kh reaction of norbornadiene and N-Boc-propargylamine to prepare 4,5-dissubstituted cyclopentenones.