Acetylides
Medchemexpress LLC Tert-butyl N-(5-hydroxypentyl)carbamate | 75178-90-4 | MFCD01862955 | >97.0% | 203.28 g·mol⁻1 | C10H21NO3 | 1 G
5-(Boc-amino)-1-pentanol is a Boc-protected 5-aminopentanol used as a versatile intermediate and linker in organic and medicinal chemistry. It contains a tert-butoxycarbonyl protected amine and a primary alcohol, enabling selective deprotection and further functionalization for synthesis of peptides, small molecules, and conjugates.
- Boc-protected amine enables selective deprotection workflows.
- Primary alcohol allows further derivatization and coupling reactions.
- High purity suitable for synthetic and medicinal chemistry applications.
- Defined storage stability in solvent and bulk formats.
- Useful as a linker for conjugation and building-block synthesis.
Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | 471.38 | C19H35BrO8 | 100 MG
Propargyl-PEG8-bromide is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal bromide. It is used for bioconjugation and linker synthesis, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and functioning as a non-cleavable ADC and PROTAC linker.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition.
- Provides an eight-unit polyethylene glycol spacer for flexibility and solubility.
- Has a terminal bromide for nucleophilic substitution or further functionalization.
- Suitable for ADC and PROTAC linker synthesis and click chemistry applications.
- Available in small-scale laboratory quantities for research use.
eMolecules 86256-63-5 | 3-Methyl-5-(trifluoromethoxy)aniline | Apollo Scientific | MFCD09025380 | 191.153 | C8H8F3NO | 98.000 | Cc1cc(N)cc(OC(F)(F)F)c1 | 1g | 562453643
3-Methyl-5-(trifluoromethoxy)aniline | Apollo Scientific | 86256-63-5 | MFCD09025380 | 191.153 | C8H8F3NO | 98.000 | Cc1cc(N)cc(OC(F)(F)F)c1 | 1g | 562453643
Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG
This compound is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It acts as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Application: Can be employed in the synthesis of PROTACs.
- Characteristics: It contains an alkyne group and can participate in copper-catalyzed azide-alkyne cycloaddition.
Medchemexpress LLC Propargyl-peg1-acid | 55683-37-9 | 97.0% | 250 MG
Propargyl-PEG1-acid is a PEG-based PROTAC linker. It is utilized in the synthesis of BTK-CRBN PROTACs and functions as a click chemistry reagent. This product incorporates an Alkyne group which can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Utilized in the synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Incorporates an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC VQW-765 | 669770-29-0 | 99.6% | 294.40 | 100 MG
VQW-765 | 669770-29-0 | 99.6% | 294.40 | 100 MG
Medchemexpress LLC (S)-VQW-765 ((S)-AQW-051) | 98.0% | 294.39 | 5 MG
(S)-VQW-765 ((S)-AQW-051) is an orally active, selective, and effective α7 nicotinic ACh receptor (nAChR) partial agonist. It has potential applications in cognitive disorders related to neurological diseases, such as Alzheimer's disease or schizophrenia.
- Orally active, selective, and effective α7 nAChR partial agonist
- Potential applications in cognitive disorders
- Suitable for neurological diseases like Alzheimer's or schizophrenia
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 | C19H37NO8 | 100 MG
Propargyl-PEG8-NH2 is a PEG-based linker reagent used for bioconjugation, including PROTAC and ADC synthesis. It contains a terminal propargyl (alkyne) group and a primary amine, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amine coupling reactions. The compound is a liquid (colorless to light yellow), with a molecular weight of 407.50 and high purity for research applications.
- Contains terminal alkyne for CuAAC click chemistry.
- Contains primary amine for amide and other coupling reactions.
- PEG8 spacer adds hydrophilicity and flexibility.
- High purity (≥98.0%).
- Available in small and bulk package sizes, including 100 mg.
- Store at 4°C, protect from light, and keep under nitrogen; long-term storage in solvent at -80°C.
Medchemexpress LLC Propargyl-PEG2-bromi 250mg
Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1] Propargyl-PEG2-bromide is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC 4,7,10,13,16,19-hexaoxadocos-21-ynoic acid | 1951438-84-8 | MFCD28950778 | >=97.0% | 348.39 | C16H28O8 | 25 MG
Propargyl-PEG6-acid is a polyethylene glycol (PEG6) linker bearing a terminal propargyl (alkyne) and a terminal carboxylic acid. It is used as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and as a linker in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs).
- Contains a terminal alkyne for CuAAC click reactions.
- Terminal carboxylic acid enables amide coupling and conjugation.
- Molecular weight 348.39; chemical formula C16H28O8.
- Suitable for use as an ADC and PROTAC linker in bioconjugation workflows.
- Recommended storage: pure material at -20°C for long-term stability.
Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | >97.0% | 224.28 g/mol | C11H12O3S | 5 G
Propargyl-tos (3-butynyl p-toluenesulfonate) is a propargyl-containing tosylate ester used as a cleavable linker and an alkynyl reagent for click chemistry, bioconjugation, and linker synthesis in medicinal chemistry. It is supplied as a purified solid for synthetic chemistry applications.
- Cleavable ADC linker and click chemistry reagent.
- Used in bioconjugation and linker synthesis.
- High purity (>97.0%) available for synthetic applications.
- Molecular weight 224.28 g/mol and formula C11H12O3S.
- Supplied in small pack sizes suitable for laboratory synthesis.
eMolecules 916420-54-7 | 3-Methyl-5-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD09025373 | 206.164 | C9H9F3O2 | 97.000 | Cc1cc(CO)cc(OC(F)(F)F)c1 | 5g | 562457352
3-Methyl-5-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 916420-54-7 | MFCD09025373 | 206.164 | C9H9F3O2 | 97.000 | Cc1cc(CO)cc(OC(F)(F)F)c1 | 5g | 562457352
![Medchemexpress LLC 2-[2-(2-propynyloxy)ethoxy]ethanamine | 944561-44-8 | MFCD19160595 | 98.9% | 143.18 g/mol | C7H13NO2 | 25 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202930.png-250.jpg)
Medchemexpress LLC 2-[2-(2-propynyloxy)ethoxy]ethanamine | 944561-44-8 | MFCD19160595 | 98.9% | 143.18 g/mol | C7H13NO2 | 25 G
Propargyl-PEG2-amine is a propargyl-terminated polyethylene glycol (PEG2) amine linker used for bioconjugation and synthetic chemistry. It is commonly used as a non-cleavable ADC linker, as a PEG-based PROTAC linker, and as a terminal alkyne reagent for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Non-cleavable ADC linker for antibody-drug conjugate synthesis.
- Suitable as a PEG-based PROTAC linker.
- Terminal alkyne enables CuAAC click reactions with azides.
- Primary amine allows amide coupling and NHS-ester chemistry.
- Molecular formula C7H13NO2 and molecular weight 143.18 g/mol.
- High reported purity (manufacturer batch example ~98.9%), batch-dependent.
- Available in multiple pack sizes, including 25 G and larger quantities.
Medchemexpress LLC Propargyl-PEG3-amine | 932741-19-0 | ≥98.0% | 187.24 | 50 MG
Propargyl-PEG3-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an alkyne group for CuAAc reactions with azide groups