Acetylides
Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 1 G
Propargyl-PEG3-bromide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a click chemistry reagent, containing an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Click chemistry
- Alkynes
- PROTAC synthesis
- Disease areas: Cancer, Cancer targeted therapy
- PROTAC linkers
Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 25 MG
Propargyl-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC N-(Propargyl-PEG4)-biocytin | 2055042-71-0 | 98.0% | C28H46N4O9S | 250 MG
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other the protein of interest, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports targeted protein degradation
Medchemexpress LLC Clodinafop-propargyl | 105512-06-9 | 98.0% | 349.74 | 10MM/1ML
Clodinafop-propargyl is a primary member of aryloxyphenoxy-propionate herbicides, utilized for the postemergence control of annual grasses in cereals. This compound also serves as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Used for postemergence control of annual grasses in cereals
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 10 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 10 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
eMolecules 1256345-96-6 | 3-Butoxy-5-(trifluoromethoxy)phenylboronic acid | Combi-Blocks | MFCD16036112 | 278.030 | C11H14BF3O4 | 97.000 | CCCCOc1cc(OC(F)(F)F)cc(c1)B(O)O | 1g | 117524581
3-Butoxy-5-(trifluoromethoxy)phenylboronic acid | Combi-Blocks | 1256345-96-6 | MFCD16036112 | 278.030 | C11H14BF3O4 | 97.000 | CCCCOc1cc(OC(F)(F)F)cc(c1)B(O)O | 1g | 117524581
Medchemexpress LLC Bis-propargyl-PEG8 50mg | 1092554-87-4 | 50 MG
Bis-propargyl-PEG8 is a polyethylene glycol-based bifunctional linker bearing terminal propargyl (alkyne) groups. It functions as a flexible PEG8 spacer for click-chemistry conjugations, PROTAC construction, and other bioconjugation applications.
- Contains two terminal propargyl (alkyne) groups for CuAAC click reactions.
- PEG8 spacer provides flexibility and increased hydrophilicity.
- Applicable to PROTAC and ADC linker synthesis and general bioconjugation workflows.
- Supplied as a solid, commonly offered in milligram quantities such as 50 mg.
- Characterized by chemical formula C22H38O9 and molecular weight 446.53 g·mol-1.
Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | MFCD29042377 | 95.0% | 471.38 | C19H35BrO8 | 250 MG
Propargyl-PEG8-bromide is a bifunctional PEG-based reagent containing a terminal alkyne and a bromide leaving group, used as a non-cleavable linker in antibody-drug conjugate (ADC) and PROTAC synthesis and as a reagent for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Contains a PEG8 spacer to increase solubility and flexibility.
- Contains a bromide leaving group for nucleophilic substitution reactions.
- Functions as a non-cleavable linker suitable for ADC and PROTAC assembly.
- Molecular weight approximately 471.4 and formula C19H35BrO8.
- Typically supplied in mg-scale quantities for research use.
Medchemexpress LLC Propargyl-PEG4-CH2CH2-Boc | 1245823-50-0 | MFCD22201534 | 95.0% | 360.44 g/mol | C18H32O7 | 500 MG
Propargyl-PEG4-CH2CH2-Boc is a PEG-based linker with a terminal propargyl (alkyne) group and a Boc-protected amine. It is used as a click-chemistry compatible linker for the synthesis of PROTACs and antibody-drug conjugates (ADCs), enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Click chemistry compatible (terminal alkyne)
- Boc-protected amine allows selective deprotection
- Molecular formula C18H32O7
- Molecular weight 360.44 g/mol
- Available in multiple pack sizes, including 500 mg
eMolecules 1129-65-3 | 1-Phenyl-1-hexyne | Ambeed | MFCD00039969 | 158.244 | C12H14 | 98.000 | CCCCC#Cc1ccccc1 | 250mg | 517263003
1-Phenyl-1-hexyne | Ambeed | 1129-65-3 | MFCD00039969 | 158.244 | C12H14 | 98.000 | CCCCC#Cc1ccccc1 | 250mg | 517263003
eMolecules 1703955-84-3 | 5-Fluoro-2-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific267.180 | C10H9F4NO3 | 95.000 | NC(Cc1cc(F)ccc1OC(F)(F)F)C(O)=O | 1g | 562457991
5-Fluoro-2-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific | 1703955-84-3267.180 | C10H9F4NO3 | 95.000 | NC(Cc1cc(F)ccc1OC(F)(F)F)C(O)=O | 1g | 562457991
Medchemexpress LLC Propargyl-PEG1-bromide | 18668-74-1 | MFCD00099299 | 98.0% | 163.01 g/mol | C5H7BrO | 250 MG
Propargyl-PEG1-bromide is a PEG-derived reagent bearing a propargyl (alkynyl) group and a terminal bromide. It serves as a reactive building block for introducing a short PEG1 spacer with an alkyne handle in synthesis workflows for chemical biology, bioconjugation, and drug delivery linker development.
- Small PEG spacer with propargyl functional group.
- Terminal bromide for alkylation or nucleophilic substitution reactions.
- Compatible with click chemistry and linker installation workflows.
- Useful for drug delivery and bioconjugation research applications.
- Molecular weight 163.01 g/mol.
- Chemical formula C5H7BrO.
- CAS number 18668-74-1.
- Typical purity 98.0%.
Medchemexpress LLC Propargyl-PEG4-Boc | 1355197-66-8 | 316.39 | 1 G
Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
eMolecules 1066-54-2 | Trimethylsilylacetylene | Chem-Impex | MFCD00008569 | 98.220 | C5H10Si | 99.000 | C[Si](C)(C)C#C | 1kg | 112760621
Trimethylsilylacetylene | Chem-Impex | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 99.000 | C[Si](C)(C)C#C | 1kg | 112760621