Hydrobromides
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 100 MG
Halofuginone hydrobromide (RU-19110 hydrobromide) is a competitive prolyl-tRNA synthetase inhibitor. This Febrifugine derivative acts as a specific inhibitor of type-I collagen synthesis and helps in attenuating osteoarthritis by inhibiting TGF-β activity. It also functions as a potent pulmonary vasodilator through the activation of Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Acts as a competitive prolyl-tRNA synthetase inhibitor.
- Inhibits type-I collagen synthesis.
- Attenuates osteoarthritis by inhibiting TGF-β activity.
- Functions as a potent pulmonary vasodilator.
- Activates Kv channels.
- Blocks voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Possesses anti-malaria effects.
- Demonstrates anti-inflammatory properties.
- Exhibits anti-cancer and anti-fibrosis effects.
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | MFCD08141806 | 463.43 g/mol | C22H27BrN2O2S | 10 MG
Eletriptan hydrobromide is the hydrobromide salt of eletriptan, a selective 5-HT1B and 5-HT1D receptor agonist supplied as an analytical standard for laboratory and research use.
- Analytical standard suitable for research and assay development.
- Selective 5-HT1B and 5-HT1D agonist for pharmacology studies.
- Reported Ki values: 0.92 nM (5-HT1B) and 3.14 nM (5-HT1D).
- Chemical formula C22H27BrN2O2S; molecular weight ~463.4 g/mol.
- Provided in small masses appropriate for analytical work.
Medchemexpress LLC Anisodamine hydrobromide | 55449-49-5 | 99.5% | 386.28 g/mol | C17H24BrNO4 | 10 MG
Anisodamine hydrobromide is the hydrobromide salt of anisodamine (6-hydroxyhyoscyamine), a belladonna alkaloid with muscarinic and nicotinic receptor activity. It is supplied as a high-purity research reagent for pharmacology and biochemical studies; not for clinical use.
- High purity (approximately 99.5%).
- Molecular weight 386.28 g/mol.
- Hydrobromide salt increases water solubility for aqueous assays.
- Supplied in small milligram quantities suitable for analytical and preclinical research.
- Commonly used in muscarinic receptor pharmacology and biochemical research applications.
Medchemexpress LLC Guvacoline hydrobrom 50mg | 17210-51-4 | 222.08 g·mol⁻¹ | C7H12BrNO2 | 50 MG
Guvacoline hydrobromide is a research-grade pyridine alkaloid that acts as a weak full agonist of atrial and ileal muscarinic acetylcholine receptors (mAChR). Supplied as a white to off-white solid with reported purity of 96.09%, it is used in receptor pharmacology and biochemical studies and is available in small laboratory pack sizes.
- White to off-white solid suitable for laboratory use.
- Reported purity of 96.09%.
- Molecular weight 222.08 g·mol⁻¹.
- Available in small pack sizes including 50 MG for bench-scale experiments.
- Store sealed at 4°C away from moisture and light; in solvent keep at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 100.0% | 349.29 | 100 MG
Pifithrin-β hydrobromide is a potent p53 inhibitor with an IC50 of 23 μM. It is considered a lead compound for cancer and neurodegenerative disease therapy. This compound, which rapidly converts from its unstable alpha form, has demonstrated neuroprotective effects in viability assays.
- Potent p53 inhibitor
- IC50 of 23 μM
- Lead compound for cancer and neurodegenerative disease research
- Exerts neuroprotective effects
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 50 MG
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. It works by inhibiting NAT10 activity, which in turn slows down DNA replication and suppresses the growth of prostate cancer cells. This compound has been shown to inhibit the growth of both prostate cancer and hepatocellular carcinoma in xenograft models. Additionally, it enhances the healthspan in a mouse model of Hutchinson-Gilford progeria syndrome (HGPS).
- Orally active and selective inhibitor.
- Inhibits NAT10 activity.
- Slows DNA replication.
- Suppresses growth of prostate cancer cells.
- Inhibits growth of hepatocellular carcinoma in xenograft models.
- Enhances healthspan in a mouse model of HGPS.
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 100 MG
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. It inhibits NAT10 activity, slows DNA replication, and suppresses the growth of prostate cancer cells. It has been shown to inhibit the growth of prostate cancer and hepatocellular carcinoma in xenograft models. Additionally, Remodelin hydrobromide enhances the healthspan in the Hutchinson-Gilford progeria syndrome (HGPS) mouse model.
- Inhibits NAT10 activity and cell proliferation in prostate cancer cells.
- Slows DNA replication.
- Suppresses the growth of prostate cancer cells.
- Inhibits the growth of hepatocellular carcinoma in xenograft models.
- Enhances healthspan in the HGPS mouse model.
- Decreases nuclear shape defects and increases genomic stability in fibroblasts.
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 100 MG
Eletriptan hydrobromide is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, exhibiting Ki values of 0.92 nM and 3.14 nM, respectively. It is intended for research use only. In vivo studies have shown that eletriptan hydrobromide dose-dependently reduces carotid blood flow in anesthetized dogs and inhibits dural plasma protein extravasation in anesthetized rats.
- Functions as a 5-HT1B and 5-HT1D receptor agonist.
- Exhibits Ki values of 0.92 nM for 5-HT1B receptor.
- Exhibits Ki values of 3.14 nM for 5-HT1D receptor.
- Dose-dependently reduces carotid blood flow in anesthetized dogs.
- Inhibits dural plasma protein extravasation in anesthetized rats.
- Completely inhibits plasma protein extravasation from the dura mater at 100 μg/kg.
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 100.0% | 349.29 | 50 MG
Pifithrin-β hydrobromide, also known as PFT β hydrobromide, is a potent p53 inhibitor with an IC50 of 23 μM. It is related to Pifithrin-α, a lead compound for cancer and neurodegenerative disease therapy, which rapidly converts to Pifithrin-β, its N-acetyl derivative. Pretreatment with 1 and 10 μM pifithrin-β has shown neuroprotective effects.
- Potent p53 inhibitor
- Exerts neuroprotective effects
- Used in cancer and neurodegenerative disease research
Medchemexpress LLC Pyrithiamine hydrobromide | 534-64-5 | 96.6% | 50 MG
Pyrithiamine hydrobromide is a thiamine analog and metabolic inhibitor used as a research reagent to study thiamine-dependent pathways and to model thiamine deficiency in cellular and animal studies.
- Thiamine metabolism inhibitor for experimental studies.
- Acts as a substrate for thiamine pyrophosphokinase.
- Suitable for biochemical and neuroscience research applications.
- Solid, white to light yellow powder with reported purity of 96.6%.
- Store at -20°C; follow recommended storage for solutions.
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 25 MG
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). It is a Febrifugine derivative and a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. This product is intended for research and analytical applications.
- Analytical standard for Halofuginone (hydrobromide)
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Specific inhibitor of type-I collagen synthesis
- Attenuates osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator (activates Kv channels and blocks voltage-gated, receptor-operated and store-operated Ca2+ channels)
- Anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Active Motif Arecoline hydrobromide
Active Motif's Arecoline hydrobromide is an inhibitor of acetyl-CoA acetyltransferase 1 (ACAT1). Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA ACAT1 by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. It is an agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM), and may be involved in dementia.
