Hydrobromides
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 1 G
Pifithrin-α hydrobromide is a chemical compound known for its role as a p53 inhibitor, effectively blocking its transcriptional activity and preventing apoptosis in cells. Additionally, it functions as an aryl hydrocarbon receptor (AhR) agonist.
- Purity of 98.58%
- Appears as a solid, white to light yellow in color
- Recommended storage at 4°C, sealed and away from moisture; in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at concentrations ≥ 50 mg/mL
- Targets p53 and aryl hydrocarbon receptor (AhR)
- Suppresses p53 protein transcription and inhibits p53-dependent apoptosis
- Acts as a potent AhR agonist, inducing DNA binding complex formation
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 5 MG
Halofuginone hydrobromide is an analytical standard of Halofuginone (hydrobromide) for research and analytical applications. This Febrifugine derivative is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It specifically inhibits type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. Furthermore, it acts as a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor
- Specific inhibitor of type-I collagen synthesis
- Attenuates osteoarthritis by inhibiting TGF-β activity
- Functions as a potent pulmonary vasodilator
- Possesses anti-malaria effects
- Exhibits anti-inflammatory effects
- Demonstrates anti-cancer effects
- Shows anti-fibrosis effects
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | MFCD00946455 | 495.59 | 100 MG
Halofuginone hydrobromide (Standard) is the analytical standard of Halofuginone (hydrobromide) and is intended for research and analytical applications. It is a Febrifugine derivative, acting as a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Specific inhibitor of type-I collagen synthesis.
- Attenuates osteoarthritis (OA) by inhibiting TGF-β activity.
- Potent pulmonary vasodilator through activation of Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Possesses anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects.
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 5mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Medchemexpress LLC Galanthamine hydrobromide (Galantamine hydrobromide) | 1953-04-4 | 99.9% | C17H22BrNO3 | 500 MG
Galanthamine hydrobromide is a selective, reversible, competitive, alkaloid AChE inhibitor with an IC50 of 0.35 μM. It also acts as a potent allosteric potentiating ligand (APL) for human α3β4, α4β2, and α6β4 nicotinic receptors (nAChRs). This compound is primarily developed for research into Alzheimer's disease (AD).
- Selective, reversible, competitive alkaloid AChE inhibitor
- Potent allosteric potentiating ligand of human α3β4, α4β2, α6β4 nicotinic receptors (nAChRs)
- Developed for Alzheimer's disease (AD) research
- IC50 of 0.35 μM for AChE
Medchemexpress LLC Amthamine dihydrobromide | 142457-00-9 | MFCD00673891 | 99.6% | 319.07 g·mol⁻¹ | C6H13Br2N3S | 5 MG
Amthamine dihydrobromide is the dihydrobromide salt of amthamine, a selective histamine receptor agonist used in pharmacology and receptor research. It is supplied as a purified solid for use in in vitro and in vivo assays to probe histamine receptor function and signaling.
- High reported purity: 99.6%.
- Molecular weight 319.07 g·mol⁻¹.
- Supplied as a solid dihydrobromide salt.
- Suitable for histamine receptor pharmacology and assay work.
- Available in small milligram pack sizes for research use.
Medchemexpress LLC Darifenacin (hydrobromide) | 133099-07-7 | 99.38% | C28H31BrN2O2 | 1 ML
Darifenacin hydrobromide, a selective M3 muscarinic receptor (M3R) antagonist, is provided as a 10 mM solution in 1 mL of DMSO. It is used in studies of urinary incontinence and overactive bladder symptoms. Research also highlights its ability to inhibit tumor growth in colorectal cancer cells, demonstrating anti-tumor effects.
- Selective M3 muscarinic receptor antagonist
- Potential for urinary incontinence and overactive bladder research
- Inhibits tumor growth in colorectal cancer cells
- Supplied as a 10 mM solution in 1 mL DMSO
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 100 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist. It is a water-soluble compound that can suppress p53 protein transcription and block glucose oxidase (GOX)-induced Bcl-2 protein reduction and Bax increase.
- Blocks transcriptional activity of p53
- Prevents cells from apoptosis
- Acts as an aryl hydrocarbon receptor (AhR) agonist
- Suppresses p53 protein transcription
- Blocks GOX-induced Bcl-2 protein reduction and Bax increase
- Induces AhR DNA binding complex formation
- Activates reporter activity
- Up-regulates the classic AhR target gene CYP1A1
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 500 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity, preventing cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist. This water-soluble compound can suppress p53 protein transcription and glucose oxidase (GOX)-induced p53 protein increase.
- Blocks p53 transcriptional activity
- Prevents cells from apoptosis
- Acts as an aryl hydrocarbon receptor (AhR) agonist
- Suppresses p53 protein transcription
- Blocks GOX-induced Bcl-2 protein reduction and prevents Bax increase
- Binds to AhR and activates reporter activity
- Up-regulates classic AhR target gene CYP1A1
Apexbio Technology LLC NAN-190 hydrobromide 115338-32-4 100mg
NAN-190 hydrobromide (CAS 115338-32-4) is a selective antagonist of the serotonin 5-HT1A receptor functioning by inhibiting receptor-mediated signal transduction pathways In receptor binding assays NAN-190 hydrobromide demonstrates high affinity for 5-HT1A receptors and modulates neurotransmitter release This compound is frequently employed in neurobiology and psychiatric disorder studies to investigate 5-HT1A-related mechanisms serving as a valuable tool for elucidating serotonergic signaling and its implications in neural function and pathology
Medchemexpress LLC Amthamine dihydrobromide | 142457-00-9 | MFCD00673891 | 99.6% | 319.07 g·mol⁻¹ | C6H13Br2N3S | 25 MG
Amthamine dihydrobromide is the dihydrobromide salt of amthamine, a histamine receptor agonist active at H1-H4 receptors. It is supplied as a solid and in ready-to-use DMSO solution formats for pharmacological research, and includes storage recommendations for both solids and stock solutions.
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 25 MG
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). It is a Febrifugine derivative and a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. This product is intended for research and analytical applications.
- Analytical standard for Halofuginone (hydrobromide)
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Specific inhibitor of type-I collagen synthesis
- Attenuates osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator (activates Kv channels and blocks voltage-gated, receptor-operated and store-operated Ca2+ channels)
- Anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS