Hydrobromides
Medchemexpress LLC Burixafor (hydrobromide) | 1191450-19-7 | 98.0% | 769.01 | 50 MG
Burixafor hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits CXCL12 binding to CXCR4, antagonizes Gαᵢ and β-arrestin2 recruitment, and blocks downstream Gαᵢ-mediated effects on cAMP signal transduction. This compound mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist with a pIC50 of 7.4.
- Inhibits CXCL12 binding to CXCR4.
- Antagonizes CXCL12-induced Gαᵢ and β-arrestin2 recruitment.
- Blocks downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
- Mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC).
- Useful for research on autologous hematopoietic stem cell transplantation (ASCT).
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 5mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Medchemexpress LLC Arecoline | 63-75-2 | MFCD00005704 | 1 ML
Arecoline is a naturally occurring psychoactive alkaloid that is brain-penetrant and orally active. It acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors. This compound has been observed to exhibit stimulation, alertness, anxiolysis, and anti-parasitic effects, though it can also induce oxidative stress.
- Purity: 99.84%
- Molecular weight: 155.19
- Formula: C8H13NO2
- Appearance: liquid
- Color: light yellow to brown
- Structure classification: alkaloids, piperidine alkaloids
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors
- Induces stimulation, alertness, anxiolysis, and anti-parasitic effects
- Can alleviate anxiety and depression in CFA-induced mice
Medchemexpress LLC Carbamimidothioic acid, C,C'-(1,4-phenylenedi-2,1-ethanediyl) ester, hydrobromide (1:2) | 157254-60-9 | 98.0% | C12H20Br2N4S2 | 10MG
1,4-PBIT (dihydrobromide) is the dihydrobromide salt of the small-molecule 1,4-PBIT, supplied for research use. The compound is documented by manufacturer COA and SDS, and is provided as a white to off-white solid with molecular formula C12H20Br2N4S2, molecular weight 444.25, and reported purity 98.0%.
- 98.0% purity as reported on the certificate of analysis
- White to off-white solid form for solid-handling workflows
- Molecular formula C12H20Br2N4S2 and molecular weight 444.25
- Recommended storage: in solvent -80°C (6 months) or -20°C (1 month), sealed
- Used as a nitric oxide synthase inhibitor in research applications
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | MFCD00946455 | 100.0% | 495.59 g/mol | C16H18Br2ClN3O3 | 10 MG
Halofuginone hydrobromide is the hydrobromide salt of halofuginone, a febrifugine-derived small molecule that competitively inhibits prolyl-tRNA synthetase and is supplied for research applications studying fibrosis, inflammation, malaria, and cancer. It is provided as a white to off-white solid with high purity and defined storage and solvent recommendations.
- Hydrobromide salt for improved handling and solubility.
- Competitive prolyl-tRNA synthetase inhibitor used in mechanistic research.
- High purity suitable for research applications.
- White to off-white solid, soluble in DMSO (≈50 mg/mL) and water (≈2.6 mg/mL).
- Store sealed and away from moisture; in solution keep at -80°C for long-term stability.
- Applicable for preclinical studies of fibrosis, inflammation, malaria, and cancer pathways.
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 1 G
Pifithrin-α hydrobromide is a chemical compound known for its role as a p53 inhibitor, effectively blocking its transcriptional activity and preventing apoptosis in cells. Additionally, it functions as an aryl hydrocarbon receptor (AhR) agonist.
- Purity of 98.58%
- Appears as a solid, white to light yellow in color
- Recommended storage at 4°C, sealed and away from moisture; in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at concentrations ≥ 50 mg/mL
- Targets p53 and aryl hydrocarbon receptor (AhR)
- Suppresses p53 protein transcription and inhibits p53-dependent apoptosis
- Acts as a potent AhR agonist, inducing DNA binding complex formation
Medchemexpress LLC Arecoline | 63-75-2 | 100 MG
Arecoline is a naturally brain-penetrant and orally active psychoactive alkaloid. It functions as a partial agonist of nicotinic and muscarinic acetylcholine receptors. It has been observed to exhibit stimulation, alertness, anxiolysis, and anti-parasitic effects. Research indicates it can also induce oxidative stress.
- Partial agonist of nicotinic and muscarinic acetylcholine receptors
- Exhibits stimulation and alertness
- Demonstrates anxiolysis and anti-parasitic effects
- Induces generation of reactive oxygen species
- Causes cell cycle arrest at G1/G0 phase in HaCaT cells
- Upregulates hemeoxygenase-1, ferritin light chain, glucose-6-phosphate dehydrogenase, glutamate-cysteine ligase catalytic subunit, and glutathione reductase expression
- Alleviates anxiety and depression in CFA-induced mice
Medchemexpress LLC Pifithrin-α (hydrobromide) | 63208-82-2 | C16H19BrN2OS | 50 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.
- Blocks p53 transcriptional activity.
- Prevents cells from apoptosis.
- Acts as an aryl hydrocarbon receptor (AhR) agonist.
- Suppresses glucose oxidase (GOX)-induced p53 protein increase.
- Reduces Bcl-2 protein and prevents Bax increase.
- Up-regulates the classic AhR target gene CYP1A1.
- Demonstrates in vivo efficacy in reducing aortic rupture and normalizing aortic morphology in Foxe3-/- mice.
Medchemexpress LLC Vortioxetine hydrobromide | 960203-27-4 | C18H23BrN2S | 5 MG
Vortioxetine hydrobromide is a multimodal serotonergic agent that acts as an antagonist of 5-HT3A and 5-HT7 receptors and an inhibitor of 5-hydroxytryptamine transporter (SERT). It also functions as a 5-HT1A agonist and a partial 5-HT1B agonist. This product is intended for research use only and has not been fully validated for medical applications.
- Antagonist of 5-HT3A and 5-HT7 receptors
- Inhibitor of 5-hydroxytryptamine transporter (SERT)
- 5-HT1A agonist and partial 5-HT1B agonist
- Multimodal serotonergic agent
- Increases cell proliferation and cell survival
- Stimulates maturation of immature granule cells
- Does not cause cognitive or psychomotor impairment
eMolecules 62595-74-8 | 3-Bromopiperidine-2,6-dione | Synthonix | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 5g | 532154821
3-Bromopiperidine-2,6-dione | Synthonix | 62595-74-8 | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 5g | 532154821
eMolecules 62595-74-8 | 3-bromopiperidine-2,6-dione | Abosyn Chemicals Inc. | MFCD11053059 | 192.012 | C5H6BrNO2 | 0.000 | BrC1CCC(=O)NC1=O | 10g | 812065079
3-bromopiperidine-2,6-dione | Abosyn Chemicals Inc. | 62595-74-8 | MFCD11053059 | 192.012 | C5H6BrNO2 | 0.000 | BrC1CCC(=O)NC1=O | 10g | 812065079
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 25 MG
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). It is a Febrifugine derivative and a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. This product is intended for research and analytical applications.
- Analytical standard for Halofuginone (hydrobromide)
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Specific inhibitor of type-I collagen synthesis
- Attenuates osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator (activates Kv channels and blocks voltage-gated, receptor-operated and store-operated Ca2+ channels)
- Anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 100.0% | 349.29 | 100 MG
Pifithrin-β hydrobromide is a potent p53 inhibitor with an IC50 of 23 μM. It is considered a lead compound for cancer and neurodegenerative disease therapy. This compound, which rapidly converts from its unstable alpha form, has demonstrated neuroprotective effects in viability assays.
- Potent p53 inhibitor
- IC50 of 23 μM
- Lead compound for cancer and neurodegenerative disease research
- Exerts neuroprotective effects
Medchemexpress LLC (RS)-AMPA hydrobromide | 171259-81-7 | 99.5% | 267.08 g/mol | C7H11BrN2O4 | 10 MG
(RS)-AMPA hydrobromide is the hydrobromide salt of (RS)-AMPA, a glutamate analogue and selective agonist of AMPA-type glutamate receptors. Supplied as a white to off-white solid for research use in neuroscience and pharmacology studies where a water-soluble AMPA receptor agonist is required.
- Selective AMPA receptor agonist.
- CAS number 171259-81-7.
- Molecular weight 267.08 g/mol.
- Purity 99.5%.
- White to off-white solid.
- Solubility: DMSO 50 mg/mL; H2O 5 mg/mL (may require ultrasonic).
- Storage: sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Burixafor (hydrobromide) | 1191450-19-7 | 98.0% | 769.01 | 1 ML
Burixafor hydrobromide is a potent CXCR4 antagonist that inhibits the binding of CXCL12 to CXCR4 and blocks downstream signaling. It mobilizes CD34+ hematopoietic stem/progenitor cells from bone marrow to peripheral blood. This compound is used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist with a pIC50 of 7.4.
- Inhibits binding of CXCL12 to CXCR4.
- Mobilizes CD34+ hematopoietic stem/progenitor cells.
- Useful for research on autologous hematopoietic stem cell transplantation.