Hydrobromides
TARGETMOL CHEMICALS INC TC-E 5003 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 uM. Purity 97.01%
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | C27H51N8O3P·5/2 HBr | 10 MG
Burixafor hydrobromide is the hydrobromide salt of burixafor, a selective, orally active CXCR4 antagonist supplied as a research reagent for preclinical and in vitro studies of CXCR4-mediated biology, including cancer metastasis, angiogenesis, and hematopoietic stem cell mobilization.
- Selective CXCR4 antagonist for receptor-targeted studies.
- High purity (98.0%) suitable for research applications.
- Water soluble (≈50 mg/mL) with ultrasonic assistance.
- Solid, light yellow to yellow appearance for easy handling.
- Recommended storage at -20°C under nitrogen for stability.
- Available in small research quantity (10 MG).
Medchemexpress LLC Galanthamine hydrobromide | 1953-04-4 | MFCD00067672 | 99.9% | C17H22BrNO3 | 100 MG
Galanthamine hydrobromide is a selective, reversible, and competitive alkaloid acetylcholinesterase (AChE) inhibitor with an IC50 of 0.35 μM. It also acts as a potent allosteric potentiating ligand (APL) for human α3β4, α4β2, and α6β4 nicotinic receptors (nAChRs). This compound is developed for research related to Alzheimer's disease (AD).
- Selective, reversible, competitive AChE inhibitor
- Potent allosteric potentiating ligand for human nicotinic receptors
- Reduces cognitive deficits in APP23 mice
- Protects against Aβ toxicity in SH-SY5Y cells
Apexbio Technology LLC Arecoline hydrobromide 300-08-3 500mg
Arecoline hydrobromide (CAS 300-08-3) is a nicotinic alkaloid that acts as a partial agonist at muscarinic acetylcholine receptors M1 M4 In electrophysiological studies it significantly inhibits the hERG potassium channel current with an IC50 of 9 55 mol/L The compound s inhibitory effect on IhERG displays concentration time and voltage dependency with blockade intensity influenced by stimulation frequency Subcutaneous administration in mice yields an LD50 of 100 mg/kg Arecoline hydrobromide is utilized in research on cardiac electrophysiology and muscarinic receptor pharmacology particularly for investigating frequency- and state-dependent modulation of cardiac ion channels
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 50 MG
Halofuginone hydrobromide (RU-19110) is a Febrifugine derivative that acts as a competitive prolyl-tRNA synthetase inhibitor. It is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. This compound exhibits various biological effects, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrosis activities. It also functions as a potent pulmonary vasodilator.
- Competitive prolyl-tRNA synthetase inhibitor.
- Inhibits type-I collagen synthesis.
- Attenuates osteoarthritis by inhibiting TGF-β activity.
- Potent pulmonary vasodilator, activating Kv channels and blocking Ca2+ channels.
- Exhibits anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrosis effects.
- Decreases NRF2 protein levels in tumors.
- Partially reverses established pulmonary hypertension.
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 1 ML
Eletriptan hydrobromide is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, primarily used as a laboratory chemical for research purposes. It appears as an off-white to light brown solid with a molecular weight of 463.43.
- 5-HT1B and 5-HT1D receptor agonist
- Demonstrates antimigraine activity
- Ki values of 0.92 nM for 5-HT1B receptor
- Ki values of 3.14 nM for 5-HT1D receptor
- Off-white to light brown solid appearance
- Reduces carotid blood flow in anesthetized dogs (in vivo)
- Inhibits dural plasma protein extravasation in anesthetized rats (in vivo)
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | 100 MG
Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood and can be used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist with a pIC50 of 7.4
- Inhibits CXCL12 binding to CXCR4
- Antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2
- Blocks downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction
- Mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from bone marrow to peripheral blood
- Can be used for research on autologous hematopoietic stem cell transplantation (ASCT)
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | 500 MG
Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood.
- Can be used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist.
- Inhibits CXCL12 binding to CXCR4.
- Blocks Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
- Mobilizes CD34+ hematopoietic stem/progenitor cells.
eMolecules 62595-74-8 | 3-Bromopiperidine-2,6-dione | Synthonix - Stock | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 1g | 476497459
3-Bromopiperidine-2,6-dione | Synthonix - Stock | 62595-74-8 | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 1g | 476497459
Medchemexpress LLC S-(2-aminoethyl) methanethiosulfonate hydrobromide | 16599-33-0 | 97.9% | 25 MG
MTSEA hydrobromide is a sulfhydryl-reactive reagent that selectively modifies free cysteine residues to introduce a positively charged side chain roughly the size of lysine. It is used in biochemical and electrophysiological studies to probe cysteine accessibility and to introduce charge at engineered cysteine sites.
- Sulfhydryl-reactive reagent for targeted cysteine modification.
- High supplied purity of 97.9%.
- Molecular weight 236.15 g/mol; formula C3H10BrNO2S2.
- Available in small solid packs suitable for research use.
- Store sealed at -20°C; in solution store at -80°C for long-term stability.
- CAS number 16599-33-0 for unambiguous identification.
Apexbio Technology LLC Imetit dihydrobromide 32385-58-3 10mg
Imetit dihydrobromide (CAS 32385-58-3) is a potent high-affinity agonist of histamine H3 and H4 receptors demonstrating Ki values of 0 3 nM and 2 7 nM respectively Functionally it replicates histaminergic effects by inducing morphological changes in eosinophils with an EC50 of 25 nM Owing to its selective receptor activity Imetit dihydrobromide is widely employed in studies investigating allergic inflammatory processes including asthma as well as in research focused on central nervous system physiology and histamine-related pathways