Hydrobromides
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 100 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist. It is a water-soluble compound that can suppress p53 protein transcription and block glucose oxidase (GOX)-induced Bcl-2 protein reduction and Bax increase.
- Blocks transcriptional activity of p53
- Prevents cells from apoptosis
- Acts as an aryl hydrocarbon receptor (AhR) agonist
- Suppresses p53 protein transcription
- Blocks GOX-induced Bcl-2 protein reduction and Bax increase
- Induces AhR DNA binding complex formation
- Activates reporter activity
- Up-regulates the classic AhR target gene CYP1A1
Apexbio Technology LLC NAN-190 hydrobromide 115338-32-4 200mg
NAN-190 hydrobromide (CAS 115338-32-4) is a selective antagonist of the serotonin 5-HT1A receptor functioning by inhibiting receptor-mediated signal transduction pathways In receptor binding assays NAN-190 hydrobromide demonstrates high affinity for 5-HT1A receptors and modulates neurotransmitter release This compound is frequently employed in neurobiology and psychiatric disorder studies to investigate 5-HT1A-related mechanisms serving as a valuable tool for elucidating serotonergic signaling and its implications in neural function and pathology
Apexbio Technology LLC SR 95531 hydrobromide 104104-50-9 5mg
SR 95531 hydrobromide (CAS 104104-50-9) also known as Gabazine is a selective competitive antagonist of the GABAA receptor By binding to the GABA recognition site on the receptor it blocks the activation induced by -aminobutyric acid (GABA) Experimental studies report an inhibitory concentration (IC50) of approximately 0 2 M for GABAA receptor-mediated responses Widely utilized in neuroscience research Gabazine is applied to investigate the physiological and pathological roles of GABAA receptor-mediated synaptic transmission neural network modulation and neurotransmitter regulation
Apexbio Technology LLC NAN-190 hydrobromide 115338-32-4 100mg
NAN-190 hydrobromide (CAS 115338-32-4) is a selective antagonist of the serotonin 5-HT1A receptor functioning by inhibiting receptor-mediated signal transduction pathways In receptor binding assays NAN-190 hydrobromide demonstrates high affinity for 5-HT1A receptors and modulates neurotransmitter release This compound is frequently employed in neurobiology and psychiatric disorder studies to investigate 5-HT1A-related mechanisms serving as a valuable tool for elucidating serotonergic signaling and its implications in neural function and pathology
Apexbio Technology LLC Arecoline hydrobromide 300-08-3 10mM (in 1mL DMSO)
Arecoline hydrobromide (CAS 300-08-3) is a nicotinic alkaloid that acts as a partial agonist at muscarinic acetylcholine receptors M1 M4 In electrophysiological studies it significantly inhibits the hERG potassium channel current with an IC50 of 9 55 mol/L The compound s inhibitory effect on IhERG displays concentration time and voltage dependency with blockade intensity influenced by stimulation frequency Subcutaneous administration in mice yields an LD50 of 100 mg/kg Arecoline hydrobromide is utilized in research on cardiac electrophysiology and muscarinic receptor pharmacology particularly for investigating frequency- and state-dependent modulation of cardiac ion channels
Medchemexpress LLC (RS)-AMPA hydrobromide | 171259-81-7 | 99.5% | 267.08 g/mol | C7H11BrN2O4 | 10 MG
(RS)-AMPA hydrobromide is the hydrobromide salt of (RS)-AMPA, a glutamate analogue and selective agonist of AMPA-type glutamate receptors. Supplied as a white to off-white solid for research use in neuroscience and pharmacology studies where a water-soluble AMPA receptor agonist is required.
- Selective AMPA receptor agonist.
- CAS number 171259-81-7.
- Molecular weight 267.08 g/mol.
- Purity 99.5%.
- White to off-white solid.
- Solubility: DMSO 50 mg/mL; H2O 5 mg/mL (may require ultrasonic).
- Storage: sealed at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Amthamine dihydrobromide | 142457-00-9 | MFCD00673891 | 99.6% | 319.07 g·mol⁻¹ | C6H13Br2N3S | 25 MG
Amthamine dihydrobromide is the dihydrobromide salt of amthamine, a histamine receptor agonist active at H1-H4 receptors. It is supplied as a solid and in ready-to-use DMSO solution formats for pharmacological research, and includes storage recommendations for both solids and stock solutions.
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 100 MG
Eletriptan hydrobromide is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, exhibiting Ki values of 0.92 nM and 3.14 nM, respectively. It is intended for research use only. In vivo studies have shown that eletriptan hydrobromide dose-dependently reduces carotid blood flow in anesthetized dogs and inhibits dural plasma protein extravasation in anesthetized rats.
- Functions as a 5-HT1B and 5-HT1D receptor agonist.
- Exhibits Ki values of 0.92 nM for 5-HT1B receptor.
- Exhibits Ki values of 3.14 nM for 5-HT1D receptor.
- Dose-dependently reduces carotid blood flow in anesthetized dogs.
- Inhibits dural plasma protein extravasation in anesthetized rats.
- Completely inhibits plasma protein extravasation from the dura mater at 100 μg/kg.
Medchemexpress LLC Darifenacin (hydrobromide) | 133099-07-7 | 99.38% | C28H31BrN2O2 | 1 ML
Darifenacin hydrobromide, a selective M3 muscarinic receptor (M3R) antagonist, is provided as a 10 mM solution in 1 mL of DMSO. It is used in studies of urinary incontinence and overactive bladder symptoms. Research also highlights its ability to inhibit tumor growth in colorectal cancer cells, demonstrating anti-tumor effects.
- Selective M3 muscarinic receptor antagonist
- Potential for urinary incontinence and overactive bladder research
- Inhibits tumor growth in colorectal cancer cells
- Supplied as a 10 mM solution in 1 mL DMSO
Medchemexpress LLC Scopolamine hydrobromide trihydrate | 6533-68-2 | 99.86% | 438.31 | 5 MG
Scopolamine (Hyoscine) hydrobromide trihydrate is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. It competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. It can induce cognitive and memory deficits in animals and is used in research for preventing postoperative nausea and vomiting, motion sickness, and nervous system diseases. This product is for research use only and not sold to patients.
- High-affinity muscarinic antagonist
- Can cross the blood-brain barrier
- Competitively antagonizes 5-HT3 receptors
- Induces cognitive and memory deficits in animals, useful for research in these areas
- Used in research for preventing postoperative nausea and vomiting, motion sickness, nervous system diseases
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 1mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Medchemexpress LLC Darifenacin hydrobromide | 133099-07-7 | 99.78% | C28H31BrN2O2 | 100 MG
Darifenacin hydrobromide (UK-88525) is a selective and orally active antagonist of the M3 muscarinic receptor (M3R) with a pKi of 8.9. It exhibits over 20-fold greater specificity for M3R compared to other muscarinic receptors. This compound is utilized in research for studying urinary incontinence and other symptoms associated with overactive bladder. Additionally, Darifenacin hydrobromide has demonstrated inhibitory effects on tumor growth in colorectal cancer cells and possesses anti-tumor properties.
- Selective M3 muscarinic receptor antagonist
- Over 20-fold greater specificity for M3R
- Used in research for urinary incontinence and overactive bladder symptoms
- Demonstrates inhibitory effects on tumor growth in colorectal cancer cells
- Possesses anti-tumor properties