Hydrochlorides
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 100 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), and 0.3 μM (rh LOXL4). It features skin penetrability, reduces collagen deposition, and improves scar appearance. It also demonstrates high permeability across Caco-2 or MDCKII cells. In In Vivo studies, PXS-6302 hydrochloride inhibits LOX, reduces crosslinking, and improves scar appearance in porcine models. Topical application reduced collagen deposition and cross-linking in murine models, and significantly improved scar appearance in porcine injury models without reducing tissue strength.
- Irreversible lysyl oxidase inhibitor
- Readily skin penetrability
- Reduces collagen deposition
- Significantly improves scar appearance
- High permeability across Caco-2 or MDCKII cells
- Effective in murine and porcine models of injury and fibrosis
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | MFCD07368623 | 99.9% | 495.07 | 25 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. It induces proliferation and migration on endothelial cells by inducing the production of VEGF. It can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area. This product is for research use only.
- Increases proliferation of HAEC cells.
- Closes the scratch of HUVECs migration.
- Induces production of VEGF, stimulating proliferation of endothelial cells.
- Increases contraction force and improves heart function in rats after acute myocardial infarction.
- Enhances eNOS activity and reduces no-reflow area after reperfusion.
- Shows anticoagulant effect in a crush injury model in rats.
Apexbio Technology LLC Tirofiban hydrochloride monohydrate 150915-40-5 5mg
Tirofiban hydrochloride monohydrate (CAS 150915-40-5) is a small-molecule inhibitor targeting platelet glycoprotein IIb/IIIa receptors It is designed to reversibly antagonize the binding of fibrinogen to these receptors thereby inhibiting platelet aggregation and thrombus formation Tirofiban hydrochloride monohydrate exerts its biological activity primarily through selective reversible inhibition of glycoprotein IIb/IIIa-mediated platelet aggregation Based on these pharmacological properties tirofiban hydrochloride monohydrate holds research potential in antithrombotic therapy and the investigation of unstable angina and thrombus-associated cardiovascular conditions
Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.7% | 342.44 | 50 MG
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) that exhibits selectivity over NKCC1. It also acts as an inhibitor of hERG and L-type Ca2+ channels. This compound reduces GABA-induced hyperpolarization of P cells, leading to a positive shift in the P cell GABA reversal potential and an enhancement of P cell synaptic transmission. It is intended for research use only.
- Potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM)
- Selective against NKCC1
- Inhibits hERG and L-type Ca2+ channels
- Attenuates GABA-induced hyperpolarization of P cells
- Produces a positive shift in the P cell GABA reversal potential
- Enhances P cell synaptic transmission
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 100 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation at concentrations of 0.1 and 1.0 μM.
- Neuroprotective in a mouse model of Huntington's disease.
- For research use only, not for sale to patients.
Accela Chembio Inc 3-pyridylacetic Acid Hydrochloride | 25g | 6419-36-9 | MFCD00012819 | 98% | Shelf Life: 1260 Days | Moisture Sensitive
3-pyridylacetic Acid Hydrochloride | 25g | 6419-36-9 | MFCD00012819 | 98% | Shelf Life: 1260 Days | Moisture Sensitive
Chemscene ChemScene | 4-Tert-Butylpiperidine hydrochloride | 250MG | CS-0139146 | 0.97 | 69682-13-9| MFCD05865119 | 177.71
ChemScene | 4-Tert-Butylpiperidine hydrochloride | 250MG | CS-0139146 | 0.97 | 69682-13-9| MFCD05865119 | 177.71
Medchemexpress LLC TG 100572 hydrochloride | 867331-64-4 | 98.8% | 512.43 g/mol | C26H27Cl2N5O2 | 1 ML
TG 100572 Hydrochloride is the hydrochloride salt of a multi-targeted kinase inhibitor that blocks selected receptor tyrosine kinases and Src family kinases. It is provided for research use in biochemical and cell-based studies and is available as a ready-to-use solution or as a solid form.
- Multi-targeted kinase inhibitor active against receptor tyrosine kinases and Src family kinases.
- Supplied as a 10 mM solution in DMSO (1 mL) for immediate use.
- Also available as a solid with a pink to red appearance.
- High purity (~98.8%) suitable for research applications.
- Store sealed, away from moisture; in solvent store at -80°C for up to 6 months.
Sigma Aldrich Fine Chemicals Biosciences 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | 23007-85-4 | MFCD00012790 | 10MG
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | Mol Wt: 209.72 | 23007-85-4 | MFCD00012790 | 10MG
eMolecules 3,3-Difluoropiperidine-1-sulfonyl chloride | Combi-Blocks, Inc. | 1845716-99-5 | MFCD29074690 | 219.630 | C5H8ClF2NO2S | 95.000 | FC1(F)CCCN(C1)S(Cl)(=O)=O | 5g | 703124135
3,3-Difluoropiperidine-1-sulfonyl chloride | Combi-Blocks, Inc. | 1845716-99-5 | MFCD29074690 | 219.630 | C5H8ClF2NO2S | 95.000 | FC1(F)CCCN(C1)S(Cl)(=O)=O | 5g | 703124135
Medchemexpress LLC Iptakalim hydrochloride | 642407-63-4 | 98.0% | 179.73 g/mol | C9H22ClN | 10 MG
Iptakalim hydrochloride is a lipophilic para-amino small molecule used in research as an ATP-sensitive potassium (KATP) channel opener and α4β2-containing nicotinic acetylcholine receptor modulator. It is supplied as the hydrochloride salt for laboratory pharmacology and formulation studies.
- Acts as an ATP-sensitive potassium (KATP) channel opener and α4β2-containing nicotinic receptor modulator.
- CAS number 642407-63-4.
- Molecular formula C9H22ClN; molecular weight 179.73 g/mol.
- Purity 98.0%.
- Available in milligram pack sizes for research, including 10 mg.
- Solubility: water 25 mg/mL (requires warming and sonication); PBS formulations achievable.
- Storage: solid sealed at 4°C; in solution store at -80°C for long-term stability.
Apexbio Technology LLC Tirofiban hydrochloride monohydrate 150915-40-5 25mg
Tirofiban hydrochloride monohydrate (CAS 150915-40-5) is a small-molecule inhibitor targeting platelet glycoprotein IIb/IIIa receptors It is designed to reversibly antagonize the binding of fibrinogen to these receptors thereby inhibiting platelet aggregation and thrombus formation Tirofiban hydrochloride monohydrate exerts its biological activity primarily through selective reversible inhibition of glycoprotein IIb/IIIa-mediated platelet aggregation Based on these pharmacological properties tirofiban hydrochloride monohydrate holds research potential in antithrombotic therapy and the investigation of unstable angina and thrombus-associated cardiovascular conditions
Medchemexpress LLC uPSEM792 hydrochloride | 2341841-08-3 | 99.9% | 277.75 g/mol | C14H16ClN3O | 10 MG
uPSEM792 hydrochloride is an ultrapotent pharmacologically selective effector molecule (uPSEM) that acts as a high-affinity agonist for engineered PSAM4-GlyR receptors. It is provided for research use only and is commonly used in neuroscience experiments to selectively activate PSAM4-based receptors.
- High potency agonist for PSAM4-GlyR with reported Ki ≈ 0.7 nM.
- Suitable for in vitro and in vivo research applications.
- Supplied as the hydrochloride salt with high chemical purity.
- Available in small research-scale quantities for experimental use.
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 99.97% | 591.23 | 100 MG
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It has IC50s of 8.9 nM for rat uterus and 26 nM for human uterus oxytocin receptor. This compound is used as a tocolytic agent.
- Potent oxytocin receptor antagonist.
- Selective for oxytocin receptor.
- Orally bioavailable.
- Non-peptide structure.
- Used as a tocolytic agent.
- Less active on VP receptor in human liver and kidney, and rat liver and kidney.
- Exhibits similar pharmacokinetics in rats and dogs with a t1/2 of 2 hours after a single IV injection.
- Plasma clearance between 23 and 36 ml/min/kg in rats or dogs.
- Vdss values of 2.0 and 2.6 liters/kg for rats and 3.4 to 4.9 liters/kg for dogs.
- Oral bioavailabilities in rats: 14% (female) and 18% (male) at 5 mg/kg; 17% (female) and 41% (male) at 25 mg/kg.
Medchemexpress LLC Erlotinib hydrochloride | 183319-69-9 | 99.7% | 5 MG
Erlotinib hydrochloride is the hydrochloride salt of erlotinib, a quinazoline-derived epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor supplied as an analytical standard for research and analytical applications. It is presented in small pack sizes suitable for laboratory assays.
- Analytical standard for EGFR inhibitor studies.
- CAS number 183319-69-9.
- Purity 99.7% (analytical grade).
- Molecular formula C22H24ClN3O4.
- Molecular weight 429.90 g/mol.
- Available in 5 mg pack size for small-scale laboratory use.
- Suitable as a reference standard for analytical assays.