Hydrochlorides
Medchemexpress LLC IACS-9571 hydrochloride | 2319611-93-1 | 98.3% | 679.22 g/mol | C32H43ClN4O8S | 1 ML
IACS-9571 hydrochloride is a potent, selective small-molecule inhibitor of the bromodomain proteins TRIM24 and BRPF1. It is used in biochemical and cellular research to probe bromodomain function, assess target engagement, and study downstream epigenetic regulation in vitro and in cells.
- Potent TRIM24 inhibition (IC50 = 8 nM) and strong BRPF1 binding (Kd = 14 nM).
- Demonstrates cellular activity (EC50 ≈ 50 nM).
- High purity suitable for research applications (>98% reported by supplier).
- Available as a 10 mM solution in DMSO (1 mL) and as solid quantities for custom preparation.
- Molecular formula C32H43ClN4O8S; molecular weight 679.22 g/mol.
Medchemexpress LLC N-(1,3-diphenylpyrazol-5-yl)-4-nitrobenzamide | 890764-36-0 | MFCD12546140 | 99.6% | 384.39 g/mol | C22H16N4O3 | 5 MG
VU-29 is a research small molecule that acts as a positive allosteric modulator of the metabotropic glutamate 5 (mGlu5) receptor. It potentiates mGlu5 signaling with high potency and selectivity, and is supplied for laboratory research in solid or solution formats.
- Positive allosteric modulator of mGlu5 with high potency (EC50 ≈ 9 nM).
- Selective for mGlu5 versus other metabotropic glutamate receptors.
- Reported high purity suitable for biochemical and cellular assays.
- Available as small solid quantities or as 10 mM solutions in DMSO for convenience.
- Chemical formula C22H16N4O3; molecular weight 384.39 g/mol.
Medchemexpress LLC Roxindole hydrochloride | 108050-82-4 | 99.5% | 382.93 g·mol⁻1 | C23H27ClN2O | 50 MG
Roxindole hydrochloride is a research-grade small molecule used as a pharmacological tool to study serotonin and dopamine receptor activity. It functions as a 5-HT1A agonist and dopaminergic modulator and is provided as a hydrochloride salt for use in in vitro and biochemical assays.
- Used to probe 5-HT1A and dopamine receptor pharmacology
- High purity suitable for research assays (HPLC)
- Molecular weight 382.93 g·mol⁻1
- Chemical formula C23H27ClN2O; CAS 108050-82-4
- Available in small solid quantities for laboratory experiments
- Store solid at -20°C and protect from light
Medchemexpress LLC Ipn60090 dihydrochloride | 2102101-72-2 | 99.7% | 605.44 g/mol | C24H29Cl2F3N8O3 | 1 ML
IPN60090 dihydrochloride is a potent, selective small-molecule inhibitor of glutaminase 1 (GLS1), provided as a dihydrochloride salt for preclinical research. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) or as solid samples, with reported high purity and documented in vitro and in vivo activity supporting use in solid tumor studies.
- Highly selective GLS1 inhibitor with reported IC50 = 31 nM.
- Inhibits A549 cell proliferation (IC50 = 26 nM).
- Available as 10 mM solution in DMSO (1 mL) or multiple solid sizes for experimental flexibility.
- High purity suitable for biochemical and cell-based assays.
- Documented pharmacokinetic and efficacy data in preclinical models.
TARGETMOL CHEMICALS INC Anabasine 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. (±) Anabasine is a muscle relaxant that can be used for muscle relaxation during surgery.
eMolecules 1181556-77-3 | 1,2-Ethanediamine, N,N-dimethyl-N'-(tetrahydro-1,1-dioxido-3-thienyl)-, dihydrochloride | Combi-Blocks, Inc. | MFCD06682713 | 279.220 | C8H20Cl2N2O2S | 95.000 | Cl.Cl.CN(C)CCNC1CCS(=O)(=O)C1 | 1g | 586076681
1,2-Ethanediamine, N,N-dimethyl-N'-(tetrahydro-1,1-dioxido-3-thienyl)-, dihydrochloride | Combi-Blocks, Inc. | 1181556-77-3 | MFCD06682713 | 279.220 | C8H20Cl2N2O2S | 95.000 | Cl.Cl.CN(C)CCNC1CCS(=O)(=O)C1 | 1g | 586076681
Medchemexpress LLC IACS-9571 hydrochloride | 2319611-93-1 | 98.3% | 679.22 g/mol | C32H43ClN4O8S | 10 MG
IACS-9571 hydrochloride is a selective, low-nanomolar inhibitor of the TRIM24 and BRPF1 bromodomains used as a research tool to probe bromodomain biology and epigenetic regulation. It is supplied as the hydrochloride salt and is characterized by low-nanomolar binding (IC50 ≈ 8 nM for TRIM24; Kd values in the low nanomolar range for TRIM24 and BRPF1).
- Selective dual TRIM24/BRPF1 bromodomain inhibition
- Low-nanomolar potency (IC50 ≈ 8 nM)
- High purity suitable for research (~98.3%)
- Available in small research pack sizes for in vitro work
- Offered as solid and as 10 mM solutions in DMSO
Medchemexpress LLC TC-A 2317 hydrochloride | 1245907-03-2 | MFCD19690936 | >=98.0% | 392.93 | C19H29ClN6O | 1 MG
TC-A 2317 hydrochloride is the hydrochloride salt of TC-A 2317, a small-molecule Aurora kinase inhibitor used in cell-cycle and DNA damage research. It is supplied as a research reagent for biochemical and cellular studies.
- Used in cell-cycle and DNA damage pathway studies.
- Hydrochloride salt form for improved stability and solubility.
- Molecular formula C19H29ClN6O; molecular weight 392.93.
- Available in small pack sizes suitable for screening and assay work.
- Store sealed at 4°C; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Zacopride hydrochloride | 101303-98-4 | MFCD04971977 | 99.7% | 346.25 | C15H21Cl2N3O2 | 1 ML
Zacopride hydrochloride is a research-grade 5-HT3 receptor antagonist supplied as either a 10 mM solution in DMSO or as solid material for pharmacological and analytical studies. It has defined purity and physicochemical properties suitable for in vitro and in vivo protocols. Intended for research use only.
- High purity (99.69%).
- Concentration: 10 mM solution, 1 mL vial in DMSO.
- Also available as solid in multiple masses (5-100 mg; larger sizes by quote).
- Molecular weight 346.25; formula C15H21Cl2N3O2.
- CAS number 101303-98-4.
- Recommended solvent: DMSO; in vivo formulation suggestions provided.
- For research use only; not for human or clinical use.
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 100 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation at concentrations of 0.1 and 1.0 μM.
- Neuroprotective in a mouse model of Huntington's disease.
- For research use only, not for sale to patients.
Medchemexpress LLC Kevetrin hydrochloride | 66592-89-0 | 98.0% | 179.67 | 1 ML
Kevetrin hydrochloride is a potent activator of p53, inducing apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. It exhibits preferential cytotoxic activity against blast cells.
- Potent activator of p53.
- Induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells.
- Exhibits preferential cytotoxic activity against blast cells.
Medchemexpress LLC Sb-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g·mol⁻¹ | C18H23ClIN3O3S | 5 MG
SB-258585 hydrochloride is the hydrochloride salt of a selective, high-affinity antagonist for the serotonin 5-HT6 receptor. Supplied as a research-grade powder, it is intended for in vitro receptor binding and pharmacology studies and is characterized by high purity and defined storage conditions.
- Selective 5-HT6 receptor antagonist with high affinity.
- Suitable for in vitro receptor binding and pharmacological assays.
- Provided as a hydrochloride salt in powder form for accurate dosing.
- High purity (>99.7%) for reproducible results.
- Stable when stored under recommended conditions (powder: -20°C).
Medchemexpress LLC Vu 0365114 | 1208222-39-2 | 99.4% | 397.35 g·mol⁻1 | C22H14F3NO3 | 100 MG
VU 0365114 is a small-molecule selective positive allosteric modulator of the muscarinic acetylcholine receptor M5 for research use. It potentiates acetylcholine-stimulated responses in cellular assays and has been reported to increase insulin secretion in human β-cells. Reported potency is micromolar with minimal activity at M1-M4.
- Selective mAChR M5 positive allosteric modulator with EC50 ~1.6-2.7 μM.
- Demonstrated increase of acetylcholine-stimulated insulin secretion in human β-cells.
- High purity approximately 99.4%.
- Solid, light yellow to orange appearance.
- Molecular formula C22H14F3NO3; molecular weight 397.35 g·mol⁻1.
- Powder stable at -20°C for extended storage.
Medchemexpress LLC Co 101244 hydrochloride (PD 174494 hydrochloride) | 193356-17-1 | 99.9% | 377.90 g/mol | C21H28ClNO3 | 100 MG
Co 101244 hydrochloride is a research-grade small-molecule antagonist selective for NR2B (GluN2B)-containing NMDA receptors. Supplied as a light yellow solid hydrochloride salt, it is intended for pharmacology and neuroscience research to probe GluN2B-mediated signaling and receptor function. The compound is reported with high purity and is compatible with DMSO-based in vitro studies.