Hydrochlorides
Medchemexpress LLC Iso-H7 dihydrochloride | 140663-38-3 | 99.1% | 364.29 | 25 MG
Iso-H7 dihydrochloride is an inhibitor of protein kinase with IC50 values of 22 and 34 μM for PKC and PKA, respectively. It has a negative control effect on PKA in satellite cell myogenesis.
- Protein kinase inhibitor.
- Inhibits PKC (IC50 = 22 μM).
- Inhibits PKA (IC50 = 34 μM).
- Negative control of PKA on satellite cell myogenesis.
Medchemexpress LLC Numidargistat dihydrochloride | 98.5% | 360.04 g·mol^-1 | C11H24BCl2N3O5 | 100 MG
Numidargistat dihydrochloride is a research-grade small-molecule inhibitor of arginase used in preclinical immunology and oncology studies. It displays nanomolar activity against recombinant human arginase enzymes and is supplied as the dihydrochloride salt with manufacturer guidance for storage and batch-specific purity.
- Potent inhibition of arginase 1 and 2 (IC50 ≈ 86 nM and 296 nM)
- Orally bioavailable profile suitable for in vivo dosing in preclinical models
- Suitable for in vitro biochemical and cell-based assays
- Dihydrochloride salt form improves solubility and handling
- Supplied with batch COA and storage recommendations for research use only
Medchemexpress LLC Duloxetine | 116539-59-4 | MFCD06801358 | 99.9% | 297.4 g/mol | C18H19NOS | 10 MG
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in research on major depressive disorder, generalized anxiety disorder, and related indications. It selectively inhibits serotonin and norepinephrine transporters (reported Ki ≈ 4.6 nM) and shows minimal affinity for many other receptor classes. Supplied as a research-grade compound with reported purity of 99.92%.
- Selective serotonin-norepinephrine reuptake inhibitor with Ki ≈ 4.6 nM.
- High reported purity (99.9%).
- Available in small-mass packs and solution formats for research use.
- Suitable for in vitro pharmacology and biochemical assays.
- CAS number 116539-59-4 for unambiguous identification.
Medchemexpress LLC PS372424 hydrochloride | 1596362-29-6 | ≥98.0% | 625.20 | 10 MG
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. It prevents human T-cell migration in a humanized model of arthritic inflammation.
- Specific human CXCR3 agonist
- Anti-inflammatory activity
- Prevents human T-cell migration in a humanized model of arthritic inflammation
- For research use only
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 25 MG
RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It exhibits 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites.
- Selective and high affinity 5-HT2B receptor antagonist
- Orally bioavailable
- 1000-fold selectivity compared to other receptor and ion channel binding sites
- Potently displaces [3H]-5-HT from human recombinant 5-HT2B receptors
- Blocks 5-HT-evoked increases in intracellular calcium concentrations
Medchemexpress LLC Ecopipam hydrochloride | 190133-94-9 | 99.5% | 350.28 | 50 MG
Ecopipam hydrochloride (SCH 39166) is a potent, selective, and orally active antagonist of dopamine D1/D5 receptors, with Ki values of 1.2 nM and 2.0 nM, respectively. It demonstrates over 40-fold selectivity for D1/D5 receptors compared to D2, D4, 5-HT, and α2a receptors. This compound is suitable for research into conditions such as schizophrenia and obesity.
- Potent and selective dopamine D1/D5 receptor antagonist
- Exhibits high selectivity over D2, D4, 5-HT, and α2a receptors
- Orally active compound
- Utilized in schizophrenia and obesity research
- Abolishes nicotine-induced enhancement of sensory reinforcers in adult rats
- Antagonizes apomorphine-induced stereotypy in rats
Medchemexpress LLC Brl 52537 hydrochloride | 112282-24-3 | MFCD00672679 | 98.1% | 391.76 | C18H25Cl3N2O | 5 MG
BRL 52537 hydrochloride is a potent, selective kappa-opioid receptor (KOR) agonist supplied as the hydrochloride salt for research use. It is provided as a solid with high reported purity and is intended for in vitro and in vivo pharmacology studies focusing on opioid receptor signaling and neuroprotection.
- Selective kappa-opioid receptor agonist suitable for receptor pharmacology.
- High reported purity of 98.1% for reliable experimental results.
- Hydrochloride salt, solid form, stable for standard lab handling.
- Available in small research quantities, e.g., 5 mg, for dose-ranging studies.
- Molecular formula C18H25Cl3N2O and molecular weight 391.76 g/mol for stoichiometric calculations.
eMolecules 3283-05-4 | AstaTech | NNNN-TETRAKIS(4-NITROPHENYL)-14-PHENYLENEDIAMINE | 1g | 448281454 | T72300 | 98 | MFCD23135517 | 592.524 | C30H20N6O8
Medchem Express | Alarelin (Acetate) | 10mg | 446268350 | HY-17405 | 79561-22-1 | MFCD30207842 | 1287.444 | C60H86N16O16
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Medchemexpress LLC 3α-bis-(4-fluorophenyl) methoxytropane hydrochloride | 202646-03-5 | 100.0% | 379.87 g/mol | C21H24ClF2NO | 1 ML
AHN 1-055 hydrochloride is a dopamine uptake inhibitor that binds with high affinity to the dopamine transporter (DAT). It is provided as a 10 mM solution in DMSO for use in pharmacology and neuroscience research probing DAT function and dopamine reuptake. Key chemical identifiers include CAS 202646-03-5 and molecular weight 379.87 g/mol.
- Supplied as a ready-to-use 10 mM solution in DMSO.
- High potency DAT inhibitor (IC50 = 71 nM).
- High purity suitable for research use (~99.96%).
- Compact 1 mL format for small-volume assays.
Medchemexpress LLC Nisoxetine hydrochloride | 57754-86-6 | 99.9% | 25 MG
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It is an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Functions as an antidepressant
- Acts as a local anesthetic
- Blocks voltage-gated sodium channels
Medchemexpress LLC Ly2365109 hydrochloride | 1779796-27-8 | 98.7% | 421.91 | C22H28ClNO5 | 50 MG
LY2365109 hydrochloride is a potent, selective inhibitor of the glycine transporter 1 (GlyT1) used for laboratory research. It inhibits glycine uptake in hGlyT1a-expressing cells with an IC50 of 15.8 nM and is supplied as a white to off-white solid with high reported purity.
- Potent, selective GlyT1 inhibition (IC50 15.8 nM).
- High reported purity (98.7%).
- White to off-white solid suitable for handling and formulation.
- Provided with standard chemical identifiers (CAS 1779796-27-8; C22H28ClNO5; MW 421.91).
- Available in multiple pack sizes, including 50 MG for laboratory use.
Medchemexpress LLC Ly 2389575 hydrochloride | 885104-09-6 | MFCD28133385 | 99.9% | 438.58 g/mol | C15H16BrCl3N4 | 100 MG
LY2389575 hydrochloride is a selective, noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3) supplied as the hydrochloride salt for research use. It is provided as a solid for in vitro and preclinical studies, including investigations of amyloid-β toxicity.
- Selective noncompetitive mGlu3 negative allosteric modulator.
- Supplied as hydrochloride salt in solid form, white to light yellow.
- High purity: 99.9%.
- Molecular formula C15H16BrCl3N4; molecular weight 438.58 g/mol.
- Available in multiple pack sizes and as a DMSO solution for convenience.
- Recommended storage: powder -20°C (long term) or 4°C (short term); in solvent -80°C.
![Medchemexpress LLC N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 g/mol | C18H20N6O3S2 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244005.png-250.jpg)
Medchemexpress LLC N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 g/mol | C18H20N6O3S2 | 25 MG
VU 0255035 is a selective, competitive antagonist of the M1 muscarinic acetylcholine receptor used as a research compound for central nervous system studies, including seizure models and investigations of neuronal excitability. It is supplied with high purity and is available in solid and solution formats for in vitro and in vivo experiments.
- Selective M1 antagonist with reported nanomolar activity.
- Brain-penetrant compound suitable for in vivo CNS studies.
- High supplied purity (≈99.8%).
- Molecular weight 432.52 g/mol (C18H20N6O3S2).
- Available in multiple pack sizes and DMSO solution formats for easy dosing.
Medchemexpress LLC ADL-5859 hydrochloride | 850173-95-4 | 99.0% | 50 MG
ADL-5859 hydrochloride is a selective and orally active δ opioid receptor (DOR) agonist. It demonstrates inhibitory activity to the hERG channel and is suitable for pain research.
- Selective and orally active δ opioid receptor agonist
- Reverses hyperalgesia in inflamed paw of rats
- Shows antidepressant-like activity
- Exhibits inhibitory activity to hERG channel
- Inhibits cytochrome P450 2D6 (CYP2D6)
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.59% | 483.82 | 1 ML
GW405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist. It has EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values of 16.1 μM and 4772 nM for CB1. It also acts as a non-competitive CB1 antagonist, exerting its analgesic effect through a CB1 receptor dependent mechanism. It can significantly inhibit the production of cAMP stimulated by Forskolin and inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF).
- Potent, selective cannabinoid receptor 2 (CB2) agonist
- EC50 and Ki values for CB2: 0.65 nM and 3.92 nM respectively
- EC50 and Ki values for CB1: 16.1 μM and 4772 nM respectively
- Non-competitive CB1 antagonist
- Inhibits cAMP production stimulated by Forskolin
- Inhibits glycolysis by down-regulating HIF-1α