Hydrochlorides
Medchemexpress LLC Naloxone (hydrochloride) | 357-08-4 | 100.0% | 363.84 | 500 MG
Naloxone hydrochloride is an antagonist of the Opioid receptor. It alleviates opioid-overdose-induced respiratory depression and may cause pulmonary edema and cardiac arrhythmias. It is for research use only and not sold to patients.
- Functions as an antagonist of the Opioid receptor.
- Helps to counteract respiratory depression caused by opioid overdose.
- Intended for research purposes.
eMolecules AstaTech / 5-BROMOISOINDOLINE / 0.25g / 222807976 / AB3161 / 95.000 / 127168-84-7 / MFCD08234718 / 198.063 / C8H8BrN
AstaTech / 5-BROMOISOINDOLINE / 0.25g / 222807976 / AB3161 / 95.000 / 127168-84-7 / MFCD08234718 / 198.063 / C8H8BrN
Medchemexpress LLC L-778123 hydrochloride | 253863-00-2 | 99.9% | 442.34 | 1 ML
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively. For research use only, not for sale to patients. In vitro, it does not show obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM) but can generate synergistic effects with Doxorubicin, with decreased IC50s of 1.72 and 1.52 μM respectively. It inhibits myeloid leukemia cell proliferation with IC50 values of 0.2 μM-1.8 μM for cell lines, and 0.1 μM-161.8 μM in primary samples. It inhibits H-RAS prenylation in HL-60 cells, and inhibits phosphorylated MEK-1/2 level. It also inhibits lymphocyte activation and function in human PBMCs.
- Dual inhibitor of FPTase and GGPTase-I
- Shows synergistic effects with Doxorubicin
- Inhibits myeloid leukemia cell proliferation
- Inhibits H-RAS prenylation and phosphorylated MEK-1/2 level
- Inhibits lymphocyte activation and function
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 25 MG
VU-1545 is a potent metabotropic glutamate receptor 5 (mGluR5) positive allosteric modulator (PAM) with a Ki of 156 nM and an EC50 of 9.6 nM. It promotes AKT activation, efficiently doing so at concentrations as low as 0.1 and 1.0 μM. Studies have shown that VU-1545 at 10 and 100 μM promotes Akt phosphorylation. This compound is used for research purposes and is not intended for patient use.
- Potent mGluR5 positive allosteric modulator
- Ki of 156 nM for mGluR5
- EC50 of 9.6 nM for mGluR5
- Promotes AKT activation in neuronal cells
- Efficiently promotes Akt phosphorylation at 10.0 μM and 100.0 μM
Medchemexpress LLC SKF 38393 hydrochloride | 62717-42-4 | 99.5% | 291.77 | C16H18ClNO2 | 10MM 1ML
SKF 38393 hydrochloride is a selective agonist of D1-like dopamine receptors used in pharmacological research. It is provided as a ready-to-use 10 mM solution in DMSO or as a solid for custom preparation, has molecular formula C16H18ClNO2 and molecular weight 291.77 g/mol, and is reported with an IC50 of 110 nM and high purity for analytical work.
- Selective D1 receptor agonist with reported IC50 of 110 nM.
- Supplied as 10 mM solution in DMSO or as solid for custom preparation.
- High purity typically around 99.5% by HPLC.
- Molecular weight 291.77 g/mol.
- Chemical formula C16H18ClNO2.
- Intended for research use only.
Sigma Aldrich Fine Chemicals Biosciences Benidipine hydrochloride >=98% (HPLC) | 91599-74-5 | 10MG
Benidipine hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 542.02 | 91599-74-5 | 10MG
Apexbio Technology LLC Duloxetine HCl 136434-34-9 10mg
Duloxetine hydrochloride (CAS 136434-34-9) is a small molecule compound classified as a selective inhibitor of serotonin and norepinephrine reuptake By blocking the reabsorption of these neurotransmitters at the synaptic cleft duloxetine modulates serotonergic and noradrenergic signaling within the central nervous system This pharmacological action has rendered it a valuable tool in research models investigating neurochemical pathways involved in mood regulation pain perception and stress response Duloxetine HCl is commonly utilized in studies of depression anxiety and chronic pain to elucidate monoaminergic mechanisms and to evaluate therapeutic strategies targeting neurotransmitter reuptake
eMolecules 1,2-ETHANEDIAMINE,N1-(7-CHLORO-4-QUINOLINYL) | 5407-57-8 | MFCD02179802 | 1g
AstaTech | 1,2-ETHANEDIAMINE,N1-(7-CHLORO-4-QUINOLINYL) | 1g | 282982525 | 78401 | 95.000 | 5407-57-8 | MFCD02179802 | 221.690 | C11H12ClN3
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Selleck Chemical LLC Duloxetine S5071-1g
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake
eMolecules 1,2-Ethanediamine, N,N-dimethyl-N'-(tetrahydro-1,1-dioxido-3-thienyl)-, dihydrochloride | 93114-08-0 | MFCD06682713 | 1g
Combi-Blocks, Inc. | 1,2-Ethanediamine, N,N-dimethyl-N'-(tetrahydro-1,1-dioxido-3-thienyl)-, dihydrochloride | 1g | 586076681 | QZ-2993 | 95.000 | 93114-08-0 | MFCD06682713 | 279.220 | C8H20Cl2N2O2S
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Selleck Chemical LLC VU 0357121 S2795-10mg
VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM is inactive or very weakly antagonizing at other mGlu receptor subtypes
Medchemexpress LLC SB-399885 hydrochloride | 402713-81-9 | 98.3% | 482.81 g/mol | C18H22Cl3N3O4S | 100 MG
SB-399885 hydrochloride is a research-grade small molecule that functions as a selective 5-HT6 receptor antagonist for laboratory pharmacology and neuroscience studies. It is supplied as a solid reagent and should be handled and stored according to standard laboratory safety practices.
- Acts as a selective 5-HT6 receptor antagonist
- Suitable for in vitro and in vivo pharmacology studies
- Supplied as a solid with reported purity of 98.3%
- Molecular weight 482.81 g/mol; CAS 402713-81-9
- Available in multiple pack sizes for dose-ranging experiments
- For research use only; not for human or clinical use
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 25 MG
Nilotinib hydrochloride dihydrate is the dihydrate hydrochloride salt of nilotinib, a potent, orally active Bcr-Abl tyrosine kinase inhibitor used in research to study chronic myelogenous leukemia (CML) and Bcr-Abl-driven signaling. It is supplied as a solid research reagent with high purity and documented solubility and storage recommendations to support assay preparation and long-term stability.
- High purity suitable for analytical and biological studies.
- Potent Bcr-Abl tyrosine kinase inhibitor for CML research.
- Solid form with recommended sealed storage away from moisture.
- Soluble in DMSO at 100 mg/mL for assay preparation.
- Documented stability in solution and long-term storage conditions.
Medchemexpress LLC SB 202190 hydrochloride | 350228-36-3 | MFCD17215958 | ≥98.0% | 367.8 g/mol | C20H15ClFN3O | 100 MG
SB 202190 hydrochloride is a selective inhibitor of p38 mitogen-activated protein kinases used in research to probe p38α/β signaling pathways. It is supplied as the monohydrochloride salt in crystalline form and is intended for research use only.
- Selective p38α and p38β inhibitor with IC50 values of 50 nM and 100 nM.
- High affinity binding to the p38 ATP pocket (Kd ≈ 38 nM).
- Molecular weight approximately 367.8 g/mol.
- Empirical formula: C20H15ClFN3O (hydrochloride salt).
- Physical form: crystalline solid; storage at -20°C; in solution store at -80°C for long-term.
- For research use only; not for human or veterinary use.
Medchemexpress LLC (R)-DRF053 dihydrochloride | 1241675-76-2 | 99.3% | 490.43 g/mol | C23H29Cl2N7O | 5 MG
(R)-DRF053 dihydrochloride is a small-molecule kinase inhibitor (dihydrochloride salt) that potently inhibits casein kinase 1 (CK1) and cyclin-dependent kinases CDK1 and CDK5. It has been used in cellular studies to reduce CK1-dependent amyloid-beta production and is provided in small quantities for research use.
- Potent CK1 inhibition (IC50 14 nM) with additional CDK1 and CDK5 activity (IC50 220 nM and 80 nM).
- Supplied as the dihydrochloride salt for improved solubility in aqueous media.
- High purity suitable for research use (99.3%).
- Available in small research quantities (1 mg, 5 mg, 10 mg).
- Recommended storage sealed at 4°C; in solvent, store at -80°C (up to 6 months) or -20°C (up to 1 month).