Hydrochlorides
Medchemexpress LLC TAK-960 dihydrochloride | C27H36Cl2F3N7O3 | 100 MG
TAK-960 dihydrochloride is a potent, orally available, and selective inhibitor of polo-like kinase 1 (PLK1), demonstrating an IC50 of 0.8 nM. It also displays inhibitory effects on PLK2 and PLK3 with IC50 values of 16.9 nM and 50.2 nM, respectively. This compound has been shown to effectively inhibit the proliferation of various cancer cell lines and exhibits significant efficacy against multiple tumor xenografts in preclinical studies.
- Potent and selective PLK1 inhibitor (IC50 = 0.8 nM)
- Inhibits PLK2 and PLK3
- Induces G2/M cell cycle arrest in HeLa cells
- Inhibits proliferation across multiple cancer cell lines
- Exhibits significant efficacy against tumor xenografts
- Demonstrates substantial antitumor activity and good tolerability in animal models
Apexbio Technology LLC Tirofiban hydrochloride monohydrate 150915-40-5 10mM (in 1mL DMSO)
Tirofiban hydrochloride monohydrate (CAS 150915-40-5) is a small-molecule inhibitor targeting platelet glycoprotein IIb/IIIa receptors It is designed to reversibly antagonize the binding of fibrinogen to these receptors thereby inhibiting platelet aggregation and thrombus formation Tirofiban hydrochloride monohydrate exerts its biological activity primarily through selective reversible inhibition of glycoprotein IIb/IIIa-mediated platelet aggregation Based on these pharmacological properties tirofiban hydrochloride monohydrate holds research potential in antithrombotic therapy and the investigation of unstable angina and thrombus-associated cardiovascular conditions
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 5 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). PXS-4787 hydrochloride also reduces the deposition and crosslinking of collagen I secreted by human fibroblasts.
- Specific and effective pan-LOX (lysyl oxidase) inhibitor
- Abolishes lysyl oxidase activity
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4)
- Reduces the deposition and crosslinking of collagen I secreted by human fibroblasts
- For research use only
eMolecules 21987-29-1 | 4,4-Difluoropiperidine | Combi-Blocks, Inc. | MFCD03094281 | 121.131 | C5H9F2N | 98.000 | FC1(F)CCNCC1 | 25g | 794200203
4,4-Difluoropiperidine | Combi-Blocks, Inc. | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 98.000 | FC1(F)CCNCC1 | 25g | 794200203
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 5 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor that effectively targets multiple LOX enzymes, with IC50 values ranging from 0.3 μM to 3.7 μM. Its excellent skin penetrability facilitates the reduction of collagen deposition and significantly enhances the appearance of scars.
- Acts as an irreversible lysyl oxidase inhibitor
- Effective against various LOX enzyme types
- Exhibits excellent skin penetrability
- Reduces collagen deposition
- Significantly improves scar appearance
- High permeability observed in Caco-2 and MDCKII cell assays
- Inhibits LOX and reduces crosslinking in porcine injury models
- Topical application improves scar appearance in murine and porcine models
Apexbio Technology LLC Terbinafine HCl 78628-80-5 100mg
Terbinafine hydrochloride (CAS 78628-80-5) is a small-molecule inhibitor targeting squalene epoxidase It is designed to selectively inhibit this key enzyme within the fungal sterol biosynthesis pathway thereby disrupting cell membrane integrity Terbinafine hydrochloride exerts its biological activity primarily through non-competitive inhibition of squalene epoxidase In experimental studies Terbinafine hydrochloride demonstrates potent antifungal activity with reported IC50 values against fungal squalene epoxidase in the nanomolar range Based on these pharmacological properties Terbinafine hydrochloride holds research potential in antifungal drug mechanism studies fungal sterol metabolism and therapeutic strategies against fungal pathogens in experimental models
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 10 MM * 1 ML
RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It exhibits 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. This product is intended for research use only.
- Selective and high affinity 5-HT2B receptor antagonist.
- Exhibits 1000-fold selectivity for the 5-HT2B receptor.
- Orally bioavailable.
- Potently displaces [3H]-5-HT from human recombinant 5-HT2B receptors.
- Blocks 5-HT-evoked increases in intracellular calcium.
- Antagonizes 5-HT-evoked formation of inositol phosphates.
- Dose-dependently reduces faecal output in rats.
Medchemexpress LLC Ly2365109 hydrochloride | 1779796-27-8 | 98.7% | 421.91 | C22H28ClNO5 | 50 MG
LY2365109 hydrochloride is a potent, selective inhibitor of the glycine transporter 1 (GlyT1) used for laboratory research. It inhibits glycine uptake in hGlyT1a-expressing cells with an IC50 of 15.8 nM and is supplied as a white to off-white solid with high reported purity.
- Potent, selective GlyT1 inhibition (IC50 15.8 nM).
- High reported purity (98.7%).
- White to off-white solid suitable for handling and formulation.
- Provided with standard chemical identifiers (CAS 1779796-27-8; C22H28ClNO5; MW 421.91).
- Available in multiple pack sizes, including 50 MG for laboratory use.
TARGETMOL CHEMICALS INC Tirofiban 25MG
Also available in 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. Purity 99.87%
Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | 99.9% | 429.38 g/mol | C21H30Cl2N2O3 | 100 MG
ZK756326 dihydrochloride is a selective, non-peptide agonist of the CC chemokine receptor CCR8 supplied as the dihydrochloride salt for research use. The compound is provided as a high-purity solid intended for pharmacology and receptor biology studies, including in vitro receptor activation and mechanism-of-action experiments.
- High purity suitable for research assays.
- Selective agonist activity at CCR8 for receptor pharmacology.
- Supplied as a stable dihydrochloride salt for handling and formulation.
- Appropriate for in vitro signaling and binding studies.
- Store sealed and away from moisture to preserve stability.
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 50 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with an EC50 of 19.8 nM. Intended for research use only, this solid compound appears white to off-white. While it demonstrates better stability in Human Liver Microsomes, its less than ideal PK properties prevent its use as an in vivo tool.
- Positive allosteric modulator (PAM) for mGlu4
- EC50 of 19.8 nM
- Purity of 99.42%
- Solid appearance, white to off-white color
- Exhibits better stability in HLM (63% remaining) compared to RLM (2% remaining)
- Target: mGluR
Medchemexpress LLC RS-102221 hydrochloride | 187397-18-8 | 98.0% | 649.08 g/mol | C27H32ClF3N4O7S | 5 MG
RS-102221 hydrochloride is the hydrochloride salt of a selective 5-HT2C receptor antagonist supplied as a solid for research use in pharmacology and neuroscience studies. It is intended for receptor binding and functional assays and includes manufacturer guidance for storage and solubility to support reliable preparation.
- Selective 5-HT2C receptor antagonist for pharmacology research.
- White to off-white solid suitable for in vitro and in vivo studies.
- High purity: 98.0%.
- Molecular weight: 649.08 g/mol.
- Soluble in DMSO at 125 mg/mL (ultrasonic recommended).
- Store powder at -20°C for long term; stock solutions at -80°C.