Hydrochlorides
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MG
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist. It demonstrates an IC50 of 32±3 nM in LLC-PK1 cells and a dissociation constant (Kb) of 19±6 nM. This compound does not induce intracellular calcium mobilization on its own.
- Antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a)
- IC50 of 32±3 nM in LLC-PK1 cells
- Dissociation constant (Kb) of 19±6 nM
- Does not induce intracellular calcium mobilization
- Attenuates phencyclidine (PCP)-induced deficits in prepulse inhibition in vivo
Medchemexpress LLC Adl-5859 hydrochloride | 850173-95-4 | 99.7% | C24H29ClN2O3 | 10MG
ADL-5859 hydrochloride is the hydrochloride salt of a selective, orally active delta-opioid receptor agonist used as a research tool in pain pharmacology. It is supplied as a white to off-white solid with high purity and characterized potency in binding and functional assays.
- Selective delta (δ) opioid receptor agonist with low-nanomolar affinity.
- High purity (~99.7%) suitable for in vitro and in vivo studies.
- Documented potency: Ki ≈ 0.84 nM, EC50 ≈ 20 nM.
- Known off-target profile: hERG IC50 ≈ 78 μM, CYP2D6 IC50 ≈ 43 μM.
- Supplied in small lot sizes convenient for preclinical research.
Medchemexpress LLC Dazoxiben (hydrochloride) | 74226-22-5 | MFCD00866791 | 99.9% | 268.70 | C12H13ClN2O3 | 10 MM 1 ML
Dazoxiben (hydrochloride) is the hydrochloride salt of dazoxiben, a potent and orally active thromboxane (TX) synthase inhibitor used in research to probe thromboxane-mediated pathways. Supplied as a concentrated solution for laboratory use, it includes accompanying safety and handling documentation.
- Potent thromboxane synthase inhibitor for research applications.
- Provided as a 10 mM solution in DMSO, ready for dilution.
- High purity (99.9%) suitable for biochemical assays.
- Storage guidance for sealed samples: -80°C (6 months) or -20°C (1 month) in solvent.
- SDS and data sheet available for handling and safety information.
Medchemexpress LLC TC-A 2317 (hydrochloride) | 1245907-03-2 | MFCD19690936 | 99.6% | 392.93 | C19H29ClN6O | 5 MG
TC-A 2317 hydrochloride is the hydrochloride salt of TC-A 2317, a potent, orally active Aurora A kinase inhibitor used for research applications. It demonstrates high potency, selectivity, and antiproliferative activity in cancer cell models.
- Potent Aurora A inhibitor with Ki = 1.2 nM
- Selective over Aurora B (Ki = 101 nM)
- Antiproliferative activity in HCT-116 cells (IC50 = 115 nM)
- Hydrochloride salt for improved stability and handling
- High measured purity (~99.6%) suitable for research use
- Available in small-mass packaging for laboratory studies
Apexbio Technology LLC VU 0364439 1246086-78-1 100mg
VU 0364439 (CAS 1246086-78-1) is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) a member of the class C G protein-coupled receptor (GPCR) family involved in regulating glutamatergic neurotransmission In vitro studies have demonstrated that VU 0364439 enhances mGluR4 activity with an EC50 of 19 8 nM exhibiting greater maximal response and potency compared to the partially selective PAM ()-PHCCC Although its pharmacokinetic properties limit in vivo applications VU 0364439 serves as a valuable tool compound for investigating mGluR4 function and modulation in cellular assays
![Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 g·mol⁻¹ | C18H20N6O3S2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241985.png-250.jpg)
Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 g·mol⁻¹ | C18H20N6O3S2 | 50 MG
VU 0255035 is a selective, brain-penetrant muscarinic M1 receptor antagonist used as a research tool in neuroscience and pharmacology. It acts as a competitive M1 antagonist with demonstrated in vitro and in vivo activity, including reduction of cholinergic-induced neuronal depolarization and efficacy in seizure models. The compound is supplied as a well-characterized, high-purity small molecule for laboratory use.
- Selective muscarinic M1 receptor antagonist
- Brain-penetrant small molecule suitable for in vivo studies
- Demonstrated activity in electrophysiology and seizure models
- High purity suitable for pharmacology experiments
- Available in multiple laboratory-friendly package sizes
eMolecules 30796-90-8 | 2-Methylazepane Hydrochloride | 250mg
Ambeed | 222-Trimethylacetamide | 10g | 552727992 | A420019 | 754-10-9 | MFCD00008011 | 101.149 | C5H11NO
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC Zt 52656a hydrochloride | 115730-24-0 | MFCD00673899 | 100.0% | 390.87 g·mol⁻¹ | C19H26ClF3N2O | 100 MG
ZT 52656A hydrochloride is the hydrochloride salt of a selective kappa opioid receptor agonist used in research to investigate kappa-mediated analgesia and the prevention or alleviation of ocular pain. Supplied as a white to off-white solid for laboratory applications, it is intended for research use only and not for clinical or human use.
- Selective kappa opioid receptor agonist.
- High reported purity (99.98%).
- Molecular weight 390.87 g·mol⁻¹.
- White to off-white solid suitable for analytical and in vivo studies.
- Recommended storage: 4°C sealed; in solvent: -80°C up to 6 months, -20°C up to 1 month.
- Available in multiple package sizes, including 100 mg.
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 99.97% | 591.23 | 100 MG
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It has IC50s of 8.9 nM for rat uterus and 26 nM for human uterus oxytocin receptor. This compound is used as a tocolytic agent.
- Potent oxytocin receptor antagonist.
- Selective for oxytocin receptor.
- Orally bioavailable.
- Non-peptide structure.
- Used as a tocolytic agent.
- Less active on VP receptor in human liver and kidney, and rat liver and kidney.
- Exhibits similar pharmacokinetics in rats and dogs with a t1/2 of 2 hours after a single IV injection.
- Plasma clearance between 23 and 36 ml/min/kg in rats or dogs.
- Vdss values of 2.0 and 2.6 liters/kg for rats and 3.4 to 4.9 liters/kg for dogs.
- Oral bioavailabilities in rats: 14% (female) and 18% (male) at 5 mg/kg; 17% (female) and 41% (male) at 25 mg/kg.
Medchemexpress LLC MRTX9768 hydrochloride | 2629314-68-5 | 99.9% | 460.89 | 100 MG
MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells, showing marked selectivity over HCT116 MTAP-WT cells. This compound leads to sustained SDMA inhibition and demonstrates dose-dependent inhibition in MTAP-del tumors in vivo. It selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Orally active
- Targets MTAP/CDKN2A-deleted tumors
- Exhibits favorable ADME profile
- Leads to sustained SDMA inhibition
- Inhibits cell proliferation in HCT116 MTAP-del cells
eMolecules 89990-54-5 | pyrazolidine dihydrochloride | Pharmablock | MFCD16620353 | 145.030 | C3H10Cl2N2 | 97.000 | Cl.Cl.C1CNNC1 | 1g | 717427045
pyrazolidine dihydrochloride | Pharmablock | 89990-54-5 | MFCD16620353 | 145.030 | C3H10Cl2N2 | 97.000 | Cl.Cl.C1CNNC1 | 1g | 717427045
Medchemexpress LLC T-3775440 hydrochloride | 1422535-52-1 | 99.1% | 346.85 g/mol | C18H23ClN4O | 10 MG
T-3775440 hydrochloride is the hydrochloride salt of T-3775440, an irreversible lysine-specific demethylase 1 (LSD1) inhibitor used in biochemical and cellular research. It has a reported IC50 of 2.1 nM and is supplied as a solid salt for assay and mechanistic studies.
- Irreversible LSD1 inhibitor with reported IC50 = 2.1 nM.
- Hydrochloride salt form suitable for biochemical and cell-based assays.
- High purity suitable for research use (reported purity 99.13%).
- Molecular formula C18H23ClN4O; molecular weight 346.85 g/mol.
- Packaged in small research quantities for assay development and validation.
eMolecules 5407-57-8 | 1,2-ETHANEDIAMINE,N1-(7-CHLORO-4-QUINOLINYL) | AstaTech | MFCD02179802 | 221.690 | C11H12ClN3 | 95.000 | NCCNc1ccnc2cc(Cl)ccc12 | 1g | 282982525
1,2-ETHANEDIAMINE,N1-(7-CHLORO-4-QUINOLINYL) | AstaTech | 5407-57-8 | MFCD02179802 | 221.690 | C11H12ClN3 | 95.000 | NCCNc1ccnc2cc(Cl)ccc12 | 1g | 282982525
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 5 MG
TP0427736 hydrochloride is a potent ALK5 (TGF-β receptor I) kinase inhibitor supplied as the hydrochloride salt for laboratory research use. It has reported biochemical potency (IC50 2.72 nM), a molecular weight of 334.85 g/mol, and a reported purity of 99.22%.
- Potent ALK5 kinase inhibitor (IC50 2.72 nM).
- Provided as hydrochloride salt to improve solubility for assays.
- High reported purity suitable for research applications.
- Available in small pack sizes for screening and assay development.
- Molecular weight 334.85 g/mol.
Medchemexpress LLC Zt 52656a hydrochloride | 115730-24-0 | MFCD00673899 | 100.0% | 390.87 g/mol | C19H26ClF3N2O | 1 ML
ZT 52656A hydrochloride is a selective kappa opioid receptor agonist used in research to prevent or alleviate ocular pain. The compound is provided as a solid or as a ready-to-use 10 mM solution in DMSO, with high reported purity and manufacturer guidance for storage to maintain stability.
- Selective kappa opioid receptor agonist suitable for ocular pain studies.
- Available as solid or pre-dissolved 10 mM solution in DMSO for convenience.
- High reported purity for consistent experimental results.
- Multiple pack sizes accommodate small- and large-scale experiments.
- Defined storage recommendations help preserve compound stability in solid and solution forms.