Hydrochlorides
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 5 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1
- Increases cellular networks of mitochondria in human and mouse fibroblasts
- Protective effects against simulated ischemia-reperfusion injury
Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 50 MG
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9. It is intended for research use only and not sold to patients. This compound is a white to off-white solid with 99.99% purity.
- Potent and selective P2X7 receptor antagonist
- pIC50 of 6.9
- For research use only
- High purity (99.99%)
- White to off-white solid
- Reduces noxious and innocuous evoked activity in neuropathic rats
- Raises withdrawal thresholds in SNL and CCI models
- Reduces seizure severity and neuronal death in the hippocampus
- Prevents depletion of striatal DA stores
- Reduces nociceptive behaviour scores
Cayman Chemical Terbinafine hydrochloride
A broad-spectrum antifungal agent; has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml); selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively); induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and HUVECs from 90-120 μM
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 100 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation at concentrations of 0.1 and 1.0 μM.
- Neuroprotective in a mouse model of Huntington's disease.
- For research use only, not for sale to patients.
Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 25 MG
Icotinib hydrochloride is a potent and specific EGFR inhibitor that is CNS-penetrant. It is effective against wild-type and various mutant EGFR forms, including EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Potent and specific EGFR inhibitor
- CNS-penetrant
- Inhibits mutant EGFR forms: EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Terbinafine hydrochloride | 78628-80-5 | 99.86% | 327.89 | 200 MG
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. It is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. It is a click chemistry reagent, containing an Alkyne group, and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Orally active and potent antifungal agent.
- Potent non-competitive inhibitor of squalene epoxidase from Candida (Ki of 30 nM).
- Shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
- Click chemistry reagent.
Medchemexpress LLC Kevetrin hydrochloride | 66592-89-0 | 98.0% | 179.67 | 50MG
Kevetrin hydrochloride is a potent activator of p53, inducing apoptosis in both TP53 wild-type and mutant acute myeloid leukemia cells. This compound demonstrates preferential cytotoxic activity against blast cells and is intended for research use only.
- Potent activator of p53.
- Induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells.
- Exhibits preferential cytotoxic activity against blast cells.
- Significantly inhibits KASUMI-1 cell growth.
- Induces metallothionein (MT) expression in acute myeloid leukemia cells.
- Increases p53 mRNA and protein levels, and induces p21 protein production.
- Inhibits tumor growth and extends survival time in xenograft models.
Medchemexpress LLC Erlotinib (hydrochloride) | 183319-69-9 | 99.9% | 1 G
Erlotinib hydrochloride is the hydrochloride salt of erlotinib, a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase intended for research use. It inhibits purified EGFR kinase with an IC50 of 2 nM and contains an alkyne group enabling copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Inhibits EGFR kinase; IC50 = 2 nM.
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- High purity (99.94%) suitable for analytical and research applications.
- Molecular formula C22H24ClN3O4, molecular weight 429.90.
- Solid, melting point 223-225 °C; recommended storage 4 °C (sealed).
- Typically supplied as a 1 g research pack.
eMolecules 3-Pyridylacetic acid, HCl | 6419-36-9 | 5G | Purity: 98%
Combi-Blocks | 3-Pyridylacetic acid, HCl | 5G | 6419-36-9 | MFCD00012819
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Selleck Chemical LLC Duloxetine HCl S2084-10mg
Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4 6 nM used for treatment of major depressive disorder and generalized anxiety disorder (GAD)
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 1 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor. It demonstrates high permeability across cell monolayers and reduces collagen deposition. This compound has shown significant improvement in scar appearance in porcine models of excisional and burn injury under topical application.
- Irreversible lysyl oxidase inhibitor
- Reduces collagen deposition
- Significantly improves scar appearance
- Readily skin penetrability
Medchemexpress LLC Drp1i27 (dihydrochloride) | C20H28Cl2N6O | 25 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1 through hydrogen bonds to Gln34 and Asp218. This product targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Potent inhibitor of human Drp1 (dynamin-related protein 1)
- Binds to the GTPase site of Drp1
- Targets Drp1-mediated mitochondrial fission in cell line models
- Protects against simulated ischemia-reperfusion injury
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner
![Medchemexpress LLC 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride | 172895-15-7 | 99.5% | 372.89 g·mol⁻¹ | C21H24N2O2·HCl | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211724.png-250.jpg)
Medchemexpress LLC 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride | 172895-15-7 | 99.5% | 372.89 g·mol⁻¹ | C21H24N2O2·HCl | 100 MG
LY-272015 hydrochloride is a selective, orally active 5-HT2B receptor antagonist supplied as the hydrochloride salt for research use. Provided as an off-white to light yellow solid, it is used in pharmacology and receptor-binding studies to probe serotonergic signaling and cardiovascular effects in preclinical models.
- Selective 5-HT2B receptor antagonist for targeted pharmacological studies.
- High purity suitable for research and assay development.
- Hydrochloride salt in solid form for stable handling and storage.
- Applicable to in vitro receptor assays and in vivo pharmacology studies.
- Well characterized in the literature with established physicochemical data.
eMolecules 8-(TRIFLUOROMETHYL)QUINOLIN-2-AMINE | 1092304-80-7 | MFCD11108677 | 1g
AstaTech | 8-(TRIFLUOROMETHYL)QUINOLIN-2-AMINE | 1g | 410712978 | 82802 | 95.000 | 1092304-80-7 | MFCD11108677 | 212.175 | C10H7F3N2
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Medchemexpress LLC TAK-960 dihydrochloride | 1137868-52-0 | C27H36Cl2F3N7O3 | 50 MG
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.
- Causes accumulation of G2-M cells, aberrant polo mitosis morphology, and increased phosphorylation of histone H3 (pHH3).
- Inhibits proliferation of multiple cancer cell lines (e.g., HT-29, HCT116, HeLa) with mean EC50 values from 8.4 to 46.9 nM, not affecting normal cells.
- In HeLa cells, 8 nM leads to G2/M cell cycle arrest without significant cytotoxicity.
- In animal models, it shows substantial antitumor activity and good tolerability against HT-29 colorectal cancer xenografts.