Hydrochlorides
Medchemexpress LLC 4-Hydroxytryptamine 1mg | 55206-11-6 | 387.41 | C14H21N5O6S | 1 MG
4-Hydroxytryptamine creatinine sulfate is the creatinine sulfate salt of 4-hydroxytryptamine (serotonin). It is a tryptamine derivative used as a research reagent and acts as a neurotransmitter agonist; reported activities include inhibition of [3H] norepinephrine uptake and modulation of norepinephrine release in animal studies.
- High purity: 97.9% (assay).
- Solid powder form, suitable for analytical and biological studies.
- Molecular weight 387.41 g·mol⁻¹.
- Chemical formula C14H21N5O6S.
- Provided in milligram-scale pack sizes for research use.
- Documentation available: COA, SDS, and elemental analysis report.
Medchemexpress LLC Icotinib hydrochloride | 1204313-51-8 | C22H22ClN3O4 | 50 MG
Icotinib Hydrochloride (BPI-2009) is a potent, CNS-penetrant, and specific EGFR inhibitor with an IC50 of 5 nM. It also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q. This compound functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Potent, CNS-penetrant, and specific EGFR inhibitor
- Inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M, and EGFRL861Q
- Has an IC50 of 5 nM for EGFR
- Functions as a click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Exhibits potent dose-dependent antitumor effects in nude mice
- Blocks EGFR-mediated intracellular tyrosine phosphorylation (IC50=45 nM)
- Well tolerated in mice without significant body weight loss
Apexbio Technology LLC Duloxetine HCl 136434-34-9 10mM (in 1mL DMSO)
Duloxetine hydrochloride (CAS 136434-34-9) is a small molecule compound classified as a selective inhibitor of serotonin and norepinephrine reuptake By blocking the reabsorption of these neurotransmitters at the synaptic cleft duloxetine modulates serotonergic and noradrenergic signaling within the central nervous system This pharmacological action has rendered it a valuable tool in research models investigating neurochemical pathways involved in mood regulation pain perception and stress response Duloxetine HCl is commonly utilized in studies of depression anxiety and chronic pain to elucidate monoaminergic mechanisms and to evaluate therapeutic strategies targeting neurotransmitter reuptake
eMolecules Ethyl 3-ethoxy-3-iminopropionate, HCl | 2318-25-4 | 5G | Purity: 97%
Combi-Blocks | Ethyl 3-ethoxy-3-iminopropionate, HCl | 5G | 2318-25-4 | MFCD00051405
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
eMolecules O-Ethylhydroxylamine hydrochloride97% | 3332-29-4 | 1G
Chem-Impex | O-Ethylhydroxylamine hydrochloride97% | 1G | 3332-29-4 | MFCD28894683 | MW:88.225
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC HBED dihydrochloride | 35369-53-0 | MFCD04113603 | ≥95.0% | 461.34 g·mol⁻¹ | C20H26Cl2N2O6 | 250 MG
HBED dihydrochloride (CAS 35369-53-0) is an orally active, hexadentate phenolic aminocarboxylate iron chelator used in biochemical and pharmacological research to model iron binding and to study iron-overload in preclinical systems. Supplied as a white to off-white solid dihydrochloride salt, it is characterized by formula C20H26Cl2N2O6 and molecular weight 461.34 g·mol⁻¹.
- Orally active hexadentate iron chelator.
- Useful for in vitro and in vivo iron chelation studies.
- White to off-white solid form, easy to handle and weigh.
- Molecular formula C20H26Cl2N2O6; molecular weight 461.34 g·mol⁻¹.
- High purity suitable for research applications (product documentation shows ≥95.0% with a reported 91.66% data-sheet variant).
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | 99.98% | 403.00 | 1MG
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker with antianginal activity. It is intended for research use only. In vivo, it reduces heart rate and mean arterial pressure, decreases mean coronary vascular resistance, and increases stroke volume in rats.
- Functions as a calcium channel blocker
- Possesses antianginal activity
- Reduces heart rate and mean arterial pressure
- Decreases mean coronary vascular resistance
- Increases stroke volume
- For research applications only
Medchemexpress LLC Tak-960 dihydrochloride | 2320307-83-1 | C27H36Cl2F3N7O3 | 10 MM 1 ML
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 nM and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and demonstrates significant efficacy against various tumor xenografts.
- Acts as a selective inhibitor of polo-like kinase 1 (PLK1)
- Shows inhibitory activities against PLK2 and PLK3
- Causes accumulation of G2-M cells
- Leads to aberrant polo mitosis morphology
- Increases phosphorylation of histone H3 (pHH3)
- Induces G2/M cell cycle arrest in HeLa cells without significant cytotoxicity
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against multiple tumor xenografts
Cayman Chemical Terbinafine hydrochloride
A broad-spectrum antifungal agent; has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml); selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively); induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and HUVECs from 90-120 μM
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 100 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. While it exhibits less than ideal PK properties for in vivo use, it demonstrates better stability in HLM (63% remaining) compared to RLM (2% remaining).
- mGlu4 positive allosteric modulator
- Exhibits an EC50 of 19.8 nM
- Shows improved stability in HLM (63% remaining) compared to RLM (2% remaining)
- Soluble in DMSO (50 mg/mL)
- Targets mGluR in GPCR/G Protein and neuronal signaling pathways
Selleck Chemical LLC Terbinafine-50mg
Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
Medchemexpress LLC Doxapram hydrochloride hydrate | 7081-53-0 | 99.3% | 25 MG
Doxapram hydrochloride hydrate | 7081-53-0 | 99.3% | 25 MG
Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 1 ML
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9, suitable for research applications. It blocks BzATP-evoked changes in intracellular calcium concentrations with an IC50 of 321 nM in rat P2X7 receptor-expressing cells, showing selectivity up to 100 μM. It has demonstrated efficacy in reducing pain and seizure severity in various in vivo models.
- Potent and selective P2X7 receptor antagonist
- Blocks BzATP-evoked intracellular calcium changes
- Selective for P2X7 receptor
- Reduces noxious and innocuous evoked activity in neuropathic rats
- Raises withdrawal thresholds in SNL and CCI models
- Reduces seizure severity and neuronal death
- Prevents 6-OHDA-induced depletion of striatal dopamine stores
- Reduces nociceptive behavior