Hydrochlorides
Medchemexpress LLC Co 101244 hydrochloride | 193356-17-1 | 99.9% | 377.90 | C21H28ClNO3 | 10 MG
Co 101244 hydrochloride (PD 174494 hydrochloride) is a selective antagonist of NR2B (GluN2B)-containing NMDA receptors used to study NMDA receptor pharmacology and neuronal signaling in vitro. The hydrochloride salt is characterized by formula C21H28ClNO3, molecular weight 377.90 g/mol, and supplier-reported purity near 99.9%. It is supplied in small-molecule formats for research assays.
- Selective antagonist of NR2B-containing NMDA receptors.
- High chemical purity for reproducible experimental results.
- Hydrochloride salt form for improved solubility in assay solvents.
- Suitable for in vitro pharmacology and receptor binding assays.
- Available in mg-scale solid and DMSO solution formats.
- Molecular weight and formula provided for dosing calculations.
eMolecules 1181556-77-3 | 1,2-Ethanediamine, N,N-dimethyl-N'-(tetrahydro-1,1-dioxido-3-thienyl)-, dihydrochloride | Combi-Blocks, Inc. | MFCD06682713 | 279.220 | C8H20Cl2N2O2S | 95.000 | Cl.Cl.CN(C)CCNC1CCS(=O)(=O)C1 | 1g | 586076681
1,2-Ethanediamine, N,N-dimethyl-N'-(tetrahydro-1,1-dioxido-3-thienyl)-, dihydrochloride | Combi-Blocks, Inc. | 1181556-77-3 | MFCD06682713 | 279.220 | C8H20Cl2N2O2S | 95.000 | Cl.Cl.CN(C)CCNC1CCS(=O)(=O)C1 | 1g | 586076681
Apexbio Technology LLC Terbinafine 91161-71-6 200mg
Terbinafine is an allylamine-class antifungal that exerts fungicidal effects by selectively inhibiting fungal squalene epoxidase thereby disrupting ergosterol biosynthesis and altering fungal cell membrane integrity Research demonstrates Terbinafine s broad-spectrum activity against diverse dermatophytes molds and select dimorphic fungal pathogens with in vitro IC50 values generally ranging from approximately 0 001 to 0 06 g/mL dependent on fungal strain and experimental condition In biological and biomedical studies Terbinafine is frequently employed as a pharmacological tool to probe antifungal mechanisms screen fungal susceptibility profiles and investigate therapeutic strategies against fungal infections
Medchemexpress LLC VU0360172 hydrochloride | 1309976-62-2 | 98.9% | 330.78 | C18H16ClFN2O | 5 MG
VU0360172 hydrochloride is a potent, selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5). It potentiates mGlu5 signaling (EC50 = 16 nM; Ki = 195 nM) and is supplied as a white to off-white solid for research use. Typical applications include receptor pharmacology, cellular signaling assays, and in vivo pharmacology studies.
- Potent mGlu5 PAM activity (EC50 16 nM).
- Confirmed binding affinity (Ki 195 nM).
- High purity suitable for research (98.9%).
- Molecular weight 330.78 for accurate dosing and calculations.
- Solid form, white to off-white, for convenient handling and storage.
- Recommended storage: store sealed at -20°C; in solution, -80°C for long term.
- Supplied in small research pack sizes appropriate for pilot studies.
Sigma Aldrich Fine Chemicals Biosciences 4-Methylmorpholine BioXtra, suitable for protein sequencing, >=99.5% (GC) | 109-02-4 | MFCD00006175 | 500ML
4-Methylmorpholine BioXtra, suitable for protein sequencing, >=99.5% (GC) | Purity: >=99.5% (GC) | Mol Wt: 101.15 | 109-02-4 | MFCD00006175 | 500ML
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 5 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1
- Increases cellular networks of mitochondria in human and mouse fibroblasts
- Protective effects against simulated ischemia-reperfusion injury
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 g/mol | C11H17ClN2O3 | 10 MG
Nifenalol hydrochloride is a β-adrenergic receptor antagonist used in pharmacological research. It is supplied as a solid and as a pre-made DMSO solution for convenient dosing and assay preparation, and is commonly used in biochemical and electrophysiological studies of β-adrenoceptor activity.
- High purity (99.9%) suitable for biochemical and cellular assays.
- Available in small solid quantities and as 10 mM solutions in DMSO for convenience.
- Supports studies of β-adrenergic receptor antagonism and early afterdepolarization effects.
- Characterized by CAS number 5704-60-9 and standard chemical identifiers.
- Supplied for research use with accompanying datasheet information for handling.
Medchemexpress LLC Prodipine hydrochloride | 31314-39-3 | 99.8% | 315.88 g/mol | C20H26ClN | 5 MG
Prodipine hydrochloride is a diphenyl-phosphonate derivative that acts as a dipeptidyl peptidase IV (DPP-IV) inhibitor. Supplied as the hydrochloride salt for research use, it is intended for enzymology, inhibitor screening, and preclinical biochemical assays; reported IC50 values are ~4.5 μM (purified rabbit DPP-IV) and ~30 μM (rabbit plasma).
- Potent DPP-IV inhibitory activity in vitro.
- Supplied as hydrochloride salt for improved solubility.
- High purity suitable for biochemical assays.
- Available in small milligram pack sizes for screening.
- Characterized with reported IC50 data for assay comparison.
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 25 MG
TP0427736 hydrochloride is a research-grade small-molecule inhibitor of ALK5 (TGF-β type I receptor), provided as the hydrochloride salt with characterized purity, molecular weight, solubility, and storage recommendations. It is intended for biochemical and cellular studies of TGF-β/Smad signaling.
- High purity (>99%) suitable for research applications.
- Potent ALK5 inhibition with low-nanomolar IC50 values.
- Available in milligram pack sizes for assay development and screening.
- Soluble in water and DMSO with published solubility conditions.
- Stored under low-temperature conditions to preserve stability.
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 5 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). PXS-4787 hydrochloride also reduces the deposition and crosslinking of collagen I secreted by human fibroblasts.
- Specific and effective pan-LOX (lysyl oxidase) inhibitor
- Abolishes lysyl oxidase activity
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4)
- Reduces the deposition and crosslinking of collagen I secreted by human fibroblasts
- For research use only
Medchemexpress LLC 1-(4-methoxybenzyl)-5-trifluoromethoxyisatin | 1160247-92-6 | 99.9% | 25 MG
VU 0238429 is a research-grade positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5). In vitro it shows an EC50 of 1.16 μM and >30-fold selectivity versus M1 and M3, with no potentiation of M2 or M4. Supplied as a high-purity solid or as DMSO solutions, it is intended for laboratory research use.
- Positive allosteric modulator of mAChR5.
- In vitro potency EC50 1.16 μM.
- Greater than 30-fold selectivity versus M1 and M3.
- High purity (≈99.9%).
- Available as solid or 10 mM solution in DMSO.
- Recommended storage: powder -20°C; in solvent -80°C for long-term.
Medchemexpress LLC L-778123 hydrochloride | 253863-00-2 | 99.9% | 442.34 | 1 ML
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively. For research use only, not for sale to patients. In vitro, it does not show obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM) but can generate synergistic effects with Doxorubicin, with decreased IC50s of 1.72 and 1.52 μM respectively. It inhibits myeloid leukemia cell proliferation with IC50 values of 0.2 μM-1.8 μM for cell lines, and 0.1 μM-161.8 μM in primary samples. It inhibits H-RAS prenylation in HL-60 cells, and inhibits phosphorylated MEK-1/2 level. It also inhibits lymphocyte activation and function in human PBMCs.
- Dual inhibitor of FPTase and GGPTase-I
- Shows synergistic effects with Doxorubicin
- Inhibits myeloid leukemia cell proliferation
- Inhibits H-RAS prenylation and phosphorylated MEK-1/2 level
- Inhibits lymphocyte activation and function
eMolecules 21987-29-1 | 4,4-Difluoropiperidine | AA Blocks LLC | MFCD03094281 | 121.131 | C5H9F2N | 0.000 | FC1(F)CCNCC1 | 1g | 414507975
4,4-Difluoropiperidine | AA Blocks LLC | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 0.000 | FC1(F)CCNCC1 | 1g | 414507975
Medchemexpress LLC Numidargistat dihydrochloride | 98.5% | 360.04 g·mol^-1 | C11H24BCl2N3O5 | 100 MG
Numidargistat dihydrochloride is a research-grade small-molecule inhibitor of arginase used in preclinical immunology and oncology studies. It displays nanomolar activity against recombinant human arginase enzymes and is supplied as the dihydrochloride salt with manufacturer guidance for storage and batch-specific purity.
- Potent inhibition of arginase 1 and 2 (IC50 ≈ 86 nM and 296 nM)
- Orally bioavailable profile suitable for in vivo dosing in preclinical models
- Suitable for in vitro biochemical and cell-based assays
- Dihydrochloride salt form improves solubility and handling
- Supplied with batch COA and storage recommendations for research use only
Medchemexpress LLC Duloxetine | 116539-59-4 | MFCD06801358 | 99.9% | 297.4 g/mol | C18H19NOS | 10 MG
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in research on major depressive disorder, generalized anxiety disorder, and related indications. It selectively inhibits serotonin and norepinephrine transporters (reported Ki ≈ 4.6 nM) and shows minimal affinity for many other receptor classes. Supplied as a research-grade compound with reported purity of 99.92%.
- Selective serotonin-norepinephrine reuptake inhibitor with Ki ≈ 4.6 nM.
- High reported purity (99.9%).
- Available in small-mass packs and solution formats for research use.
- Suitable for in vitro pharmacology and biochemical assays.
- CAS number 116539-59-4 for unambiguous identification.